Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Yosef Buganim"'
Autor:
Tayma Handal, Sarah Juster, Manar Abu Diab, Shira Yanovsky-Dagan, Fouad Zahdeh, Uria Aviel, Roni Sarel-Gallily, Shir Michael, Ester Bnaya, Shulamit Sebban, Yosef Buganim, Yotam Drier, Vincent Mouly, Stefan Kubicek, Walther J. A. A. van den Broek, Derick G. Wansink, Silvina Epsztejn-Litman, Rachel Eiges
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Epigenetic defects caused by hereditary or de novo mutations are implicated in various human diseases. It remains uncertain whether correcting the underlying mutation can reverse these defects in patient cells. Here we show by the analysis o
Externí odkaz:
https://doaj.org/article/f2f26f7be8be43019350e3bc09541979
Autor:
Moriyah Naama, Moran Rahamim, Valery Zayat, Shulamit Sebban, Ahmed Radwan, Dana Orzech, Rachel Lasry, Annael Ifrah, Mohammad Jaber, Ofra Sabag, Hazar Yassen, Areej Khatib, Silvina Epsztejn-Litman, Michal Novoselsky-Persky, Kirill Makedonski, Noy Deri, Debra Goldman-Wohl, Howard Cedar, Simcha Yagel, Rachel Eiges, Yosef Buganim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, a
Externí odkaz:
https://doaj.org/article/d0c4b6ee563d4a668d24fbf8c84f012e
Autor:
Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Dewi Astuti, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Samuel Lara-Reyna, Miriam E. Korsgen, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Georgina W. Hughes, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Eva-Maria Frickel, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112372- (2023)
Summary: Autophagy is a homeostatic process critical for cellular survival, and its malfunction is implicated in human diseases including neurodegeneration. Loss of autophagy contributes to cytotoxicity and tissue degeneration, but the mechanistic un
Externí odkaz:
https://doaj.org/article/b83b8c0b9a4f4ed78cbd46982db1f23d
Autor:
Mohammad Jaber, Ahmed Radwan, Netanel Loyfer, Mufeed Abdeen, Shulamit Sebban, Areej Khatib, Hazar Yassen, Thorsten Kolb, Marc Zapatka, Kirill Makedonski, Aurelie Ernst, Tommy Kaplan, Yosef Buganim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Ectopic transcription factor expression can reprogram mouse fibroblasts to pluripotent or trophoblast stem cells. Here the authors apply multi-omics analyses to the induction of pluripotency and trophoblast stem cell state from fibroblasts, comparing
Externí odkaz:
https://doaj.org/article/2c683347bd5b41c78db539dff13cbc7f
Autor:
Nataliia Stepanenko, Omri Wolk, Enrica Bianchi, Gavin James Wright, Natali Schachter-Safrai, Kiril Makedonski, Alberto Ouro, Assaf Ben-Meir, Yosef Buganim, Amiram Goldblum
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Combined hormone drugs are the basis for orally administered contraception. However, they are associated with severe side effects that are even more impactful for women in developing countries, where resources are limited. The risk of side effects ma
Externí odkaz:
https://doaj.org/article/f2cb5811de864636b916150553867994
Autor:
Carl Ward, Giacomo Volpe, Pierre Cauchy, Anetta Ptasinska, Ruba Almaghrabi, Daniel Blakemore, Monica Nafria, Doris Kestner, Jon Frampton, George Murphy, Yosef Buganim, Keisuke Kaji, Paloma García
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1496-1511.e8 (2018)
Summary: During somatic reprogramming, Yamanaka’s pioneer factors regulate a complex sequence of molecular events leading to the activation of a network of pluripotency factors, ultimately resulting in the acquisition and maintenance of a pluripote
Externí odkaz:
https://doaj.org/article/a18ab7e136ff4233bfc83f272e0f8a76
Autor:
Sovan Sarkar, Bernadette Carroll, Yosef Buganim, Dorothea Maetzel, Alex H.M. Ng, John P. Cassady, Malkiel A. Cohen, Souvik Chakraborty, Haoyi Wang, Eric Spooner, Hidde Ploegh, Joerg Gsponer, Viktor I. Korolchuk, Rudolf Jaenisch
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1302-1315 (2013)
Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not clear. Here, we show defective
Externí odkaz:
https://doaj.org/article/8ba9092dd7d24866b2276e63e6f785de
Autor:
Adit Ben-Baruch, Varda Rotter, Tsipi Meshel, Yosef Buganim, Hilla Solomon, Tal Leibovich-Rivkin
Publikováno v:
Cancers, Vol 4, Iss 1, Pp 55-76 (2012)
Here, we investigated the relative contribution of genetic/signaling components versus microenvironmental factors to the malignancy phenotype. In this system, we took advantage of non-transformed fibroblasts that carried defined oncogenic modificatio
Externí odkaz:
https://doaj.org/article/fd9857dd7e1e4a8498758336261da85b
Autor:
Yuval Tabach, Ira Kogan-Sakin, Yosef Buganim, Hilla Solomon, Naomi Goldfinger, Randi Hovland, Xi-Song Ke, Anne M Oyan, Karl-H Kalland, Varda Rotter, Eytan Domany
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14632 (2011)
Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an alternative view, chromosomal i
Externí odkaz:
https://doaj.org/article/6df0d60b27ce4405af896a5571d8e211
Autor:
Yosef Buganim, Ido Goldstein, Doron Lipson, Michael Milyavsky, Sylvie Polak-Charcon, Corine Mardoukh, Hilla Solomon, Eyal Kalo, Shalom Madar, Ran Brosh, Marina Perelman, Roy Navon, Naomi Goldfinger, Iris Barshack, Zohar Yakhini, Varda Rotter
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9657 (2010)
Partial gain of chromosome arm 17q is an abundant aberrancy in various cancer types such as lung and prostate cancer with a prominent occurrence and prognostic significance in neuroblastoma--one of the most common embryonic tumors. The specific genet
Externí odkaz:
https://doaj.org/article/a72d18ed0d5d466abdd0817d1a86e473