Zobrazeno 1 - 10
of 447
pro vyhledávání: '"Yosef, Yarden"'
Autor:
Lukas Beumers, Efstathios-Iason Vlachavas, Simone Borgoni, Luisa Schwarzmüller, Luca Penso-Dolfin, Birgitta E. Michels, Emre Sofyali, Sara Burmester, Daniela Heiss, Heike Wilhelm, Yosef Yarden, Dominic Helm, Rainer Will, Angela Goncalves, Stefan Wiemann
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this
Externí odkaz:
https://doaj.org/article/d79daab67d374819bdec862b9405046a
Autor:
Anat Gershoni, Ori Hassin, Nishanth Belugali Nataraj, Sivan Baruch, Adi Avioz‐Seligman, Anna Chiara Pirona, Liat Fellus‐Alyagor, Tomer Meir Salame, Saptaparna Mukherjee, Giuseppe Mallel, Yosef Yarden, Yael Aylon, Moshe Oren
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2675-2693 (2023)
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain‐containing transcription regulator protein 1 (WWTR1; also known as TAZ). Whe
Externí odkaz:
https://doaj.org/article/2dbf7e08c0fc4450b4c84ececd4af0cb
Autor:
Kathrin Hedegger, Andreas Blutke, Theresa Hommel, Kerstin E. Auer, Nishanth B. Nataraj, Moshit Lindzen, Yosef Yarden, Maik Dahlhoff
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2415-2431 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the eff
Externí odkaz:
https://doaj.org/article/4848dd9e7e41435b882248abb977ac66
Autor:
Elad Lax, Sonia Do Carmo, Yehoshua Enuka, Daniel M. Sapozhnikov, Lindsay A. Welikovitch, Niaz Mahmood, Shafaat A. Rabbani, Liqing Wang, Jonathan P. Britt, Wayne W. Hancock, Yosef Yarden, Moshe Szyf
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence linke
Externí odkaz:
https://doaj.org/article/ac756fae07a44e51b83b8e00c01221ca
Autor:
Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-down
Externí odkaz:
https://doaj.org/article/4ccbb8ac8c2f4c92a83690814f9d6056
Autor:
Ilaria Marrocco, Yosef Yarden
Publikováno v:
Cancers, Vol 15, Iss 20, p 5009 (2023)
Epidermal growth factor receptor (EGFR)-specific tyrosine kinase inhibitors (TKIs) have changed the landscape of lung cancer therapy. For patients who are treated with the new TKIs, the current median survival exceeds 3 years, substantially better th
Externí odkaz:
https://doaj.org/article/6466da644c0847d4ba6f15ad30112c20
Autor:
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-22 (2022)
Abstract Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra an
Externí odkaz:
https://doaj.org/article/94cbefd9495f42afb45b540ee5bc32e6
Autor:
Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The differential effects of TP53 missense mutations in colorectal cancer (CRC) remain to be explored. Here the authors compare the gain of function impact of two frequent TP53 mutations in CRC and show that p53R273 mutants control a transcriptional p
Externí odkaz:
https://doaj.org/article/a119b82dad0a479ebb369694272fe374
Autor:
Chiara Giacomelli, Janine Jung, Astrid Wachter, Susanne Ibing, Rainer Will, Stefan Uhlmann, Heiko Mannsperger, Özgür Sahin, Yosef Yarden, Tim Beißbarth, Ulrike Korf, Cindy Körner, Stefan Wiemann
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)
Abstract Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approa
Externí odkaz:
https://doaj.org/article/ece14dc9183445a5b9d8d24f84fd4050
Autor:
Gretchen Bergado-Báez, Narjara Gonzalez Suarez, Lisset Chao García, Dayana Pérez-Martínez, Diana Rosa Hernández-Fernández, Talia Fundora-Barrios, Antonio Rodríguez-Álvarez, Geidy Diana Díaz-Ordaz, Moshit Lindzen, Yosef Yarden, Belinda Sánchez-Ramírez
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundAntitumor therapies targeting HER1/EGFR and HER2, such as monoclonal antibodies (MAbs) and tyrosine-kinase inhibitors (TKIs), have demonstrated a significant clinical benefit, but the emergence of resistance limits long-term efficacy. While
Externí odkaz:
https://doaj.org/article/b6298bca5afe4fe9b20d85633b37935d