Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Yosef, E Maruvka"'
Autor:
Anirban Das, Uri Tabori, Lauren C. Sambira Nahum, Natalie B. Collins, Rebecca Deyell, Rina Dvir, Cecile Faure-Conter, Timothy E. Hassall, Jane E. Minturn, Melissa Edwards, Elissa Brookes, Vanessa Bianchi, Adrian Levine, Simone C. Stone, Sumedha Sudhaman, Santiago Sanchez-Ramirez, Ayse B. Ercan, Lucie Stengs, Jiil Chung, Logine Negm, Gad Getz, Yosef E. Maruvka, Birgit Ertl-Wagner, Pamela S. Ohashi, Trevor Pugh, Cynthia Hawkins, Eric Bouffet, Daniel A. Morgenstern
Publikováno v:
Clinical Cancer Research.
Purpose: Checkpoint-inhibitors have limited efficacy for children with unselected solid and brain tumors. We report the first prospective pediatric trial (NCT02992964) using nivolumab exclusively for refractory non-hematological cancers harboring tum
Autor:
Harald Paganetti, Aaron N. Hata, Lecia V. Sequist, Henning Willers, Zofia Piotrowska, Yosef E. Maruvka, Florian Fintelmann, Sophia C. Kamran, Changran Geng, David McClatchy, Clemens Grassberger
The importance of preexisting versus acquired drug resistance in patients with cancer treated with small-molecule tyrosine kinase inhibitors (TKI) remains controversial. The goal of this study is to provide a general estimate of the size and dynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a2ab0f88fa25613f873d6aeedd256f
https://doi.org/10.1158/0008-5472.c.6511001.v1
https://doi.org/10.1158/0008-5472.c.6511001.v1
Autor:
Harald Paganetti, Aaron N. Hata, Lecia V. Sequist, Henning Willers, Zofia Piotrowska, Yosef E. Maruvka, Florian Fintelmann, Sophia C. Kamran, Changran Geng, David McClatchy, Clemens Grassberger
This file contains supplemental figures 1-3. SF1: detailed description of sequential fitting process with example; SF2: relative uncertainties of the pre-existing resistant and persistent fractions; SF3: robustness analysis - results of the combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5061aa256cb011fad76886c7aae3e39
https://doi.org/10.1158/0008-5472.22421711.v1
https://doi.org/10.1158/0008-5472.22421711.v1
Autor:
Kirsten Kubler, Agostina Nardone, Shankara Anand, Daniel Gorvich, Marjolein Droog, Francisco Hermida-Prado, Tara Akshi, Avery S Feit, Gabriella Cohen, Gwen Dackus, Matthew Pun, Yanan Kuang, Justin Cha, Mendy Miller, William J Gibson, Cloud P Paweletz, Eliezer M Van Allen, Flora E van Leeuwen, Petra Nederlof, Harry Hollema, Quang-Dé Nguyen, Marian JE Mourits, Ignaty Leshchiner, Chip Stewart, Ursula A Matulonis, Wilbert Zwart, Yosef E Maruvka, Gad Getz, Rinath Jeselsohn
Publikováno v:
Cancer Research. 82:GS2-09
Tamoxifen is widely used in the adjuvant treatment of estrogen receptor–positive (ER+) breast cancer and is an important drug for pre-menopausal women and post-menopausal patients who cannot tolerate aromatase inhibitors. Despite the clear clinical
Autor:
Orli Michaeli, Hagay Ladany, Ayelet Erez, Shay Ben Shachar, Shai Izraeli, Gabriel Lidzbarsky, Lina Basel‐Salmon, Saskia Biskup, Yosef E. Maruvka, Helen Toledano, Yael Goldberg
Publikováno v:
Clinical Genetics. 101:442-447
Polymerase proofreading-associated polyposis (PPAP) and Lynch syndrome, caused by mutated POLE and mismatch repair (MMR) genes, respectively, are associated with adult-onset cancer. PPAP and MMR-deficient tumors are both hypermutated, and each has a
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783031250651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c65e7e4ff649187cecb9c9c0464709
https://doi.org/10.1007/978-3-031-25066-8_25
https://doi.org/10.1007/978-3-031-25066-8_25
Autor:
Jiil, Chung, Logine, Negm, Vanessa, Bianchi, Lucie, Stengs, Anirban, Das, Zhihui Amy, Liu, Sumedha, Sudhaman, Melyssa, Aronson, Ledia, Brunga, Melissa, Edwards, Victoria, Forster, Martin, Komosa, Scott, Davidson, Jodi, Lees, Patrick, Tomboc, David, Samuel, Roula, Farah, Anne, Bendel, Jeffrey, Knipstein, Kami Wolfe, Schneider, Agnes, Reschke, Shayna, Zelcer, Alexandra, Zorzi, Robert, McWilliams, William D, Foulkes, Raymond, Bedgood, Lindsay, Peterson, Sara, Rhode, An, Van Damme, Isabelle, Scheers, Sharon, Gardner, Gabriel, Robbins, Magimairajan Issai, Vanan, M Stephen, Meyn, Rebecca, Auer, Brandie, Leach, Carol, Burke, Anita, Villani, David, Malkin, Eric, Bouffet, Annie, Huang, Michael D, Taylor, Carol, Durno, Adam, Shlien, Cynthia, Hawkins, Gad, Getz, Yosef E, Maruvka, Uri, Tabori
Publikováno v:
Journal of Clinical Oncology, (2022)
Journal of Clinical Oncology, Vol. 41, no.4, p. 766-777 (2023)
Journal of Clinical Oncology, Vol. 41, no.4, p. 766-777 (2023)
PURPOSE Diagnosis of Mismatch Repair Deficiency (MMRD) is crucial for tumor management and early detection in patients with the cancer predisposition syndrome constitutional mismatch repair deficiency (CMMRD). Current diagnostic tools are cumbersome
Autor:
Shamam Waldman, Daniel Backenroth, Éadaoin Harney, Stefan Flohr, Nadia C. Neff, Gina M. Buckley, Hila Fridman, Ali Akbari, Nadin Rohland, Swapan Mallick, Jorge Cano Nistal, Jin Yu, Nir Barzilai, Inga Peter, Gil Atzmon, Harry Ostrer, Todd Lencz, Yosef E. Maruvka, Maike Lämmerhirt, Leonard V. Rutgers, Virginie Renson, Keith M. Prufer, Stephan Schiffels, Harald Ringbauer, Karin Sczech, Shai Carmi, David Reich
We report genome-wide data for 33 Ashkenazi Jews (AJ), dated to the 14th century, following a salvage excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically similar to modern AJ and have substantial Sout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd0b314f6a257d6b42ed4dbcf9de7fe
https://doi.org/10.1101/2022.05.13.491805
https://doi.org/10.1101/2022.05.13.491805
Autor:
Shamam, Waldman, Daniel, Backenroth, Éadaoin, Harney, Stefan, Flohr, Nadia C, Neff, Gina M, Buckley, Hila, Fridman, Ali, Akbari, Nadin, Rohland, Swapan, Mallick, Iñigo, Olalde, Leo, Cooper, Ariel, Lomes, Joshua, Lipson, Jorge, Cano Nistal, Jin, Yu, Nir, Barzilai, Inga, Peter, Gil, Atzmon, Harry, Ostrer, Todd, Lencz, Yosef E, Maruvka, Maike, Lämmerhirt, Alexander, Beider, Leonard V, Rutgers, Virginie, Renson, Keith M, Prufer, Stephan, Schiffels, Harald, Ringbauer, Karin, Sczech, Shai, Carmi, David, Reich
Publikováno v:
Cell. 185(25)
We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14
Autor:
Cynthia Hawkins, Daniel A. Morgenstern, Victoria J. Forster, Scott Lindhorst, Sumedha Sudhaman, Uri Tabori, An Van Damme, Eric Bouffet, Alexander Lossos, Ben George, Annika Bronsema, Anita Villani, Michael Osborn, Annie Huang, Yosef E. Maruvka, Melyssa Aronson, Patrick Tomboc, Michal Yalon-Oren, David S. Ziegler, Reid Hayes, Carol Durno, Vanessa Bianchi, Melissa Galati, Nuno Miguel Nunes, Magimairajan Issai Vanan, Vanja Cabric, Gregory Thomas, Nicholas Light, Scott Davidson, Matthew Zatzman, Michael D. Taylor, A. Sorana Morrissy, Martin Komosa, Melissa Edwards, Gary Mason, Jiil Chung, Adam Shlien, Gad Getz, Shriya Deshmukh, Alyssa Reddy, Karl P. Hodel, Zachary F. Pursell, Robert Siddaway, Maura Massimino, Enrico Opocher, Ledia Brunga, David Malkin, Ben Ho, Jacalyn Kelly, Daniel C. Bowers, Nathaniel D. Anderson, Valerie Larouche, Thomas A. Kunkel, Nicholas J. Haradhvala, Kristina A. Cole
Publikováno v:
Cancer Discov
Cancer discovery, Vol. 11, no. 5, p. 1176-1191 (2021)
Cancer discovery, Vol. 11, no. 5, p. 1176-1191 (2021)
Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide