Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yosaku Watatani"'
Autor:
Fumiko Arakawa, Hiroaki Miyoshi, Noriaki Yoshida, Kazutaka Nakashima, Yosaku Watatani, Takuya Furuta, Kyohei Yamada, Mayuko Moritsubo, Mai Takeuchi, Eriko Yanagida, Yasumasa Shimasaki, Kei Kohno, Keisuke Kataoka, Koichi Ohshima
Publikováno v:
Cancer Medicine, Vol 10, Iss 19, Pp 6786-6794 (2021)
Abstract Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the
Externí odkaz:
https://doaj.org/article/176dee61a1d84c8284f034011c64d474
Autor:
Yotaro Ochi, Kenichi Yoshida, Ying-Jung Huang, Ming-Chung Kuo, Yasuhito Nannya, Ko Sasaki, Kinuko Mitani, Noriko Hosoya, Nobuhiro Hiramoto, Takayuki Ishikawa, Susan Branford, Naranie Shanmuganathan, Kazuma Ohyashiki, Naoto Takahashi, Tomoiku Takaku, Shun Tsuchiya, Nobuhiro Kanemura, Nobuhiko Nakamura, Yasunori Ueda, Satoshi Yoshihara, Rabindranath Bera, Yusuke Shiozawa, Lanying Zhao, June Takeda, Yosaku Watatani, Rurika Okuda, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Akifumi Takaori-Kondo, Satoru Miyano, Seishi Ogawa, Lee-Yung Shih
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Here, the authors analyse a cohort of CML samples with genomic technologies and find that at least one driver al
Externí odkaz:
https://doaj.org/article/b8463e0b7aef42f9abaf389f4f41e7bd
Autor:
Takahiro Kumode, Shinya Rai, Hirokazu Tanaka, J. Luis Espinoza, Hiroaki Kakutani, Yosaku Watatani, Shuji Minamoto, Yasuhiro Taniguchi, Shoko Nakayama, Yasuyoshi Morita, Takashi Ashida, Itaru Matsumura
Publikováno v:
Leukemia Research Reports, Vol 14, Iss , Pp 100219- (2020)
We report a case with extramedullary tumors affecting the supraclavicular region that presented as a relapse of acute myeloid leukemia (AML) with FLT3-ITD mutation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Treatment with g
Externí odkaz:
https://doaj.org/article/80f42e8d1bae4569807a70b2fdcacd77
Autor:
Yusuke Shiozawa, Luca Malcovati, Anna Gallì, Aiko Sato-Otsubo, Keisuke Kataoka, Yusuke Sato, Yosaku Watatani, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Eva Hellström-Lindberg, Satoru Miyano, Seishi Ogawa, Mario Cazzola
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as thei
Externí odkaz:
https://doaj.org/article/d51021625acb4fb6bc05018865814b72
Autor:
Shoko Nakayama, Chikara Hirase, Masatomo Miura, Jorge Luis Espinoza, Hirokazu Tanaka, Yasuyoshi Morita, Shinya Rai, Itaru Matsumura, Sanae Sueda, Yasuhiro Taniguchi, Naoto Takahashi, Kentaro Serizawa, Yosaku Watatani, Takahiro Kumode
Publikováno v:
Internal Medicine
We recently treated a chronic myeloid leukemia (CML) patient with liver and renal dysfunction, who was undergoing hemodialysis (HD). He was treated with 50 mg dasatinib (DAS) once daily just before HD. The maximum plasma concentration of DAS was 227
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c2e4a9ba0a94ab6c161c2d0d5574e6
https://doi.org/10.2169/internalmedicine.4871-20
https://doi.org/10.2169/internalmedicine.4871-20
Autor:
Kenichi Chiba, Tomonori Hirano, Norihiro Goto, Akira Yokoyama, Yusuke Shiozawa, Hironori Haga, Ayana Kon, Seishi Ogawa, Yosaku Watatani, Yasunori Kogure, Tsutomu Chiba, Makoto Mark Taketo, Yuichi Shiraishi, Hideki Makishima, Takaaki Sato, Kenichi Yoshida, Takaki Sakurai, Ryosaku Inagaki, Takako Kihara, Takashi Maruyama, Takahiro Horimatsu, Jun Oishi, Kotaro Akaki, Eiji Sugihara, Hiroko Tanaka, Hiroki Ikeuchi, Osamu Takeuchi, Yoichi Fujii, Akinori Yoda, Hiroyuki Miyoshi, Yasuhito Nanya, Motoi Uchino, Tetsuichi Yoshizato, Yoshikage Inoue, Yoshiharu Sakai, Satoshi Nagayama, Kenji Kawada, Hiroshi Nakase, Seiichi Hirota, Yasuhide Takeuchi, Soo Ki Kim, Minoru Matsuura, Hideaki Okajima, Shinya Okamoto, Yotaro Ochi, Shuji Yamamoto, Hiroshi Seno, Masahiro Nakagawa, Nobuyuki Kakiuchi, Yutaka Ueda, Hiroyuki Marusawa, Satoru Miyano, Keisuke Kataoka, Masashi Sanada
Publikováno v:
Nature. 577:260-265
Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer1–3. However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ae2306aa7faf66da78985fe02783e53
https://doi.org/10.1038/s41586-019-1856-1
https://doi.org/10.1038/s41586-019-1856-1
Autor:
Hitoshi Hanamoto, Yosaku Watatani, Hiroaki Inoue, Yoichi Tatsumi, Takahiro Haeno, Hirokazu Tanaka, Kazuto Nishio, Kazuko Sakai, J. Luis Espinoza, Yasuhiro Maeda, Chikara Hirase, Itaru Matsumura, Shinya Rai, Takahiro Kumode, Yasuhiro Taniguchi, Mitsuhiro Matsuda, Kentaro Serizawa, Takashi Ashida, Yasuyoshi Morita
Publikováno v:
Cancer science. 113(2)
We previously examined the utility of rituximab-bendamustine (RB) in patients with follicular lymphoma (FL) exhibiting less than optimal responses to two-cycles of R-CHOP. The aim of this study was to identify molecular biomarkers that can predict pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afac98e9df94d77f1f7f103e2424dcb6
https://pubmed.ncbi.nlm.nih.gov/34837284
https://pubmed.ncbi.nlm.nih.gov/34837284
Autor:
Hirokazu Tanaka, Yoichi Tatsumi, Yasuhiro Taniguchi, Chikara Hirase, Yosaku Watatani, Kentarou Serizawa, Kazuko Sakai, J. Luis Espinoza, Yasuyoshi Morita, Shinya Rai, Kazuto Nishio, Takahiro Kumode, Yasuhiro Maeda, Hiroaki Inoue, Hitoshi Hanamoto, Itaru Matsumura, Mitsuhiro Matsuda, Takashi Ashida, Takahiro Haeno
Background: Several clinical risk stratification models have been proposed to predict the clinical outcomes of follicular lymphoma (FL) cases, however, few reports are available to predict prognosis of FL cases receiving bendamustine-based regimens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d405cac2662540625cd1ede0c8988a2
https://doi.org/10.21203/rs.3.rs-648976/v1
https://doi.org/10.21203/rs.3.rs-648976/v1
Autor:
Hiroaki Miyoshi, Mayuko Moritsubo, Fumiko Arakawa, Koichi Ohshima, Eriko Yanagida, Kei Kohno, Kazutaka Nakashima, Yasumasa Shimasaki, Kyohei Yamada, Keisuke Kataoka, Noriaki Yoshida, Yosaku Watatani, Mai Takeuchi, Takuya Furuta
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 19, Pp 6786-6794 (2021)
Cancer Medicine, Vol 10, Iss 19, Pp 6786-6794 (2021)
Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ac647e20a44bd7c0d3b7303af64cb6
https://pubmed.ncbi.nlm.nih.gov/34477310
https://pubmed.ncbi.nlm.nih.gov/34477310
Autor:
Tetsuichi Yoshizato, Yuichi Shiraishi, Nobuyuki Kakiuchi, Kengo Takeuchi, Ryota Matsuoka, Hiroko Tanaka, Yusuke Kito, Kazuya Shimoda, Tadashi Yoshino, Kenji Nishida, Takayuki Ishikawa, Kenichi Chiba, Kana Sakamoto, Lanying Zhao, Yusuke Shiozawa, Hiroaki Miyoshi, Hiroo Ueno, Nobuhiro Hiramoto, Kenichi Yoshida, Koichi Ohshima, Junichi Kitagawa, Shigeru Chiba, Yasuhito Nanya, Hisashi Tsurumi, Masashi Sanada, Nobuhiko Nakamura, Yasunobu Nagata, Yasuhide Takeuchi, Satoru Miyano, Hideki Makishima, Masayuki Noguchi, June Takeda, Keisuke Kataoka, Tatsuhiko Miyazaki, Yasuharu Sato, Mamiko Sakata-Yanagimoto, Masahiro Nakagawa, Yotaro Ochi, Yasunori Kogure, Seishi Ogawa, Yosaku Watatani, Yuka Gion
Publikováno v:
Leukemia. 33:2867-2883
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion, being the most common entity in mature T-cell neoplasms, and its molecular pathogenesis remains significantly understudied. Here, combining whole-exome and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447d6d766112fbae48ceddfacb74388
https://doi.org/10.1038/s41375-019-0473-1
https://doi.org/10.1038/s41375-019-0473-1