Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.

Autor: Bielinski M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Henderson LR; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Yosaatmadja Y; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., Swift LP; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Bowen MJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Brem J; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Jones PS; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., McElroy SP; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., Morrison A; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., Speake M; University of Dundee, European Screening Centre Newhouse ML1 5UH UK., van Boeckel S; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van Doornmalen E; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van Groningen J; Pivot Park Screening Centre 5349 AB Oss The Netherlands., van den Hurk H; Pivot Park Screening Centre 5349 AB Oss The Netherlands., Gileadi O; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., Newman JA; Centre for Medicines Discovery, NDM Research Building, University of Oxford Old Road Campus Research Building, Roosevelt Drive Oxford OX3 7DQ UK joseph.newman@cmd.ox.ac.uk., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS UK peter.mchugh@imm.ox.ac.uk., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.

Publikováno v: Chemical science [Chem Sci] 2024 Apr 30; Vol. 15 (21), pp. 8227-8241. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024).

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.

Autor: Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Brolih S; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Yosaatmadja Y; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK., Ratnaweera M; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Bielinski M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Swift LP; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Cruz-Migoni A; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Fan H; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Keown JR; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, UK., Walker AP; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Morris GM; Department of Statistics, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, UK., Grimes JM; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK., Fodor E; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Gileadi O; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Feb 22; Vol. 50 (3), pp. 1484-1500.

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Autor: Yosaatmadja Y; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK., Baddock HT; Department of Oncology, MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Newman JA; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK., Bielinski M; The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Gavard AE; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK., Mukhopadhyay SMM; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK., Dannerfjord AA; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK., Schofield CJ; The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., McHugh PJ; Department of Oncology, MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Gileadi O; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9310-9326.

A phase I drug–drug interaction study to assess the effect of futibatinib on P‐gp and BCRP substrates and of P‐gp inhibition on the pharmacokinetics of futibatinib.

Autor: Long, Amanda¹ (AUTHOR) along@taihooncology.com, Yamamiya, Ikuo² (AUTHOR), Valentine, Michelle³ (AUTHOR), Machnes, Ziv³ (AUTHOR), Hangai, Nanae¹ (AUTHOR), Anderson, Bailey¹ (AUTHOR), Wacheck, Volker¹ (AUTHOR), Gao, Ling¹ (AUTHOR)

Publikováno v: CTS: Clinical & Translational Science. Sep2024, Vol. 17 Issue 9, p1-11. 11p.

The SNM1A DNA repair nuclease.

Autor: Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK., Yosaatmadja Y; Structural Genomics Consortium, University of Oxford, OX3 7DQ, UK., Newman JA; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, UK., Gileadi O; Structural Genomics Consortium, University of Oxford, OX3 7DQ, UK., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK. Electronic address: peter.mchugh@imm.ox.ac.uk.

Publikováno v: DNA repair [DNA Repair (Amst)] 2020 Nov; Vol. 95, pp. 102941. Date of Electronic Publication: 2020 Jul 31.