Výsledky vyhledávání - "York-Fong Cheung"

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

Autor: Anna Terrin, Wolfgang R. Dostmann, Miles D. Houslay, Valentina Lissandron, David A. Kass, Marco Mongillo, Nazareno Paolocci, York Fong Cheung, Carlo G. Tocchetti, Manuela Zaccolo, Tullio Pozzan

β-Adrenergic signaling via cAMP generation and PKA activation mediates the positive inotropic effect of catecholamines on heart cells. Given the large diversity of protein kinase A targets within cardiac cells, a precisely regulated and confined act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8414bceb6f76d20805b4f3dcaed690aa
https://doi.org/10.1161/01.res.0000200178.34179.93

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Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Autor: Erik De Clercq, York-Fong Cheung, Karen M. Watson, Miles D. Houslay, Matthew D. Cullen, Christophe Pannecouque, Tracy L. Hartman, Robert W. Buckheit, Mark Cushman

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:1530-1533

The alkenyldiarylmethanes (ADAMs) are currently being investigated as non- nucleoside HIV- 1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS. During the course of these studies, a number of ADAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbe993ab73e4cfc49f0b2d177609533
https://doi.org/10.1016/j.bmcl.2007.12.015

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Constitutive activation of the G-protein subunit Gαs within forebrain neurons causes PKA-dependent alterations in fear conditioning and corticalArcmRNA expression

Autor: Ted Abel, York-Fong Cheung, Steven J. Siegel, Miles D. Houslay, Christopher G. Favilla, Michy P. Kelly, Stephen J. Kanes

Publikováno v: Learning & Memory. 15:75-83

Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that medications are administered long-term, we determined the effects of chronically increasing cAMP synthesis in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db79b4d3be3f44493a1b5437bfb71a02
https://doi.org/10.1101/lm.723708

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Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene

Autor: Irene Gall, Richard Graham Knowles, Lachlan Campbell, Thomas M. Houslay, Lee Ann Johnston, York-Fong Cheung, Michael Sullivan, Douglas MacMaster, Robin A. Smith, Derek A. Wallace, Miles D. Houslay, Elaine Huston, Jenni E. Millen

Publikováno v: Molecular Pharmacology. 67:1920-1934

PDE4A11 is a novel cAMP-specific phosphodiesterase that is conserved in humans, mouse, rat, pig, and bat. Exon-1(4A11) encodes its unique, 81 amino acid N-terminal region. Reverse-transcriptase polymerase chain reaction performed across the splice ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2c8498d063bb683d8154599ebccf2
https://doi.org/10.1124/mol.104.009423

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Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

Autor: Lee Ann Johnston, Elaine Huston, Gino Van Heeke, Suat Erdogan, Rachael Barber, Martin J. Lynch, York Fong Cheung, Michael Sullivan, David R. Adams, Miles D. Houslay, George S. Baillie

Publikováno v: Biochemical Journal. 380:371-384

PDE4A7 is an isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene that fails to hydrolyse cAMP and whose transcripts are widely expressed. Removal of either the N- or C-terminal unique portions of PDE4A7 did not reconstitute cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028d4aa9a24a6aedba51e8e6391393e3
https://doi.org/10.1042/bj20031662

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Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

Autor: Robert Terry, Morten Praestegaard, Irene Gall, Miles D. Houslay, George S. Baillie, David R. Adams, York Fong Cheung, Elaine Huston

Publikováno v: Cellular Signalling. 15:955-971

In cells transfected to express wild-type PDE4A4 cAMP phosphodiesterase (PDE), the PDE4 selective inhibitor rolipram caused PDE4A4 to relocalise so as to form accretion foci. This process was followed in detail in living cells using a PDE4A4 chimera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47684844d9956700c7137b5b4999acb
https://doi.org/10.1016/s0898-6568(03)00092-5

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Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Autor: Elaine V. Hill, Eberhard Krause, Catherine L. Sheppard, York-Fong Cheung, Miles D. Houslay, Irene Gall

Publikováno v: Cellular signalling. 18(11)

RAW macrophages, which express the PDE4D3 and PDE4D5 cAMP phosphodiesterase isoforms, exhibited increased PDE4 activity when challenged with H2O2 in a fashion that was negated by treatment with the cell permeant antioxidant, N-acetyl cysteine and by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6275baf13595eb1b8db15c4d1db3258f
https://pubmed.ncbi.nlm.nih.gov/16973330

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Constitutive Activation of Gαs within Forebrain Neurons Causes Deficits in Sensorimotor Gating Because of PKA-Dependent Decreases in cAMP

Autor: David A. Rapoport, Gary S. Wand, Stephen J. Kanes, Xioaju Yang, Steven J. Siegel, Ted Abel, Michy P. Kelly, Sara A. Fabian, Michael F. Esposito, York Fong Cheung, Miles D. Houslay, Carolina Isiegas, Jan Tokarczyk

Sensorimotor gating, the ability to automatically filter sensory information, is deficient in a number of psychiatric disorders, yet little is known of the biochemical mechanisms underlying this critical neural process. Previously, we reported that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd4e5fd830cfd811fc4145b30d214cf
https://europepmc.org/articles/PMC3303872/

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PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

Autor: Giulietta Di Benedetto, Nicola Elvassore, Martin J. Lynch, Friedrich W. Herberg, Manuela Zaccolo, York-Fong Cheung, Miles D. Houslay, Anna Terrin, Vanessa Pertegato, Anke Prinz, George S. Baillie

Publikováno v: The Journal of Cell Biology

There is a growing appreciation that the cyclic adenosine monophosphate (cAMP)–protein kinase A (PKA) signaling pathway is organized to form transduction units that function to deliver specific messages. Such organization results in the local activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941364ac5e48a93887eb49ed74bf6a09
http://hdl.handle.net/11577/1562862

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