Zobrazeno 1 - 10
of 13
pro vyhledávání: '"York Rudhard"'
Autor:
Joseph W. Lewcock, Sarah Huntwork-Rodriguez, York Rudhard, Martin Larhammar, Arundhati Sengupta-Ghosh
Publikováno v:
The Journal of Neuroscience. 37:11074-11084
The c-Jun-N-terminal kinase (JNK) signaling pathway regulates nervous system development, axon regeneration, and neuronal degeneration after acute injury or in chronic neurodegenerative disease. Dual leucine zipper kinase (DLK) is required for stress
Autor:
Hai Ngu, Oded Foreman, Yichin Liu, Joseph W. Lewcock, Alexander Böcker, Arundhati Sengupta Ghosh, York Rudhard, Joachim Krämer, Beatrix Lippert, Mehdi Pedaran
Publikováno v:
The Journal of Neuroscience. 35:2927-2941
Axon degeneration is a programed process that takes place during development, in response to neuronal injury, and as a component of neurodegenerative disease pathology, yet the molecular mechanisms that drive this process remain poorly defined. In th
Autor:
Claire E. Le Pichon, Joseph W. Lewcock, Eric J. Huang, Richard A.D. Carano, Michael Siu, Hai Ngu, Arundhati Sengupta Ghosh, Sebum Lee, Xingrong Liu, Zhiyu Jiang, William J. Meilandt, York Rudhard, Amy Gustafson, Sara L. Dominguez, Han Lin, Robby M. Weimer, Seung-Hye Lee, Bei Wang, Christine Pozniak, Snahel Patel, Vineela D. Gandham, Hilda Solanoy, Oded Foreman, Alvin Gogineni, Janice A. Maloney, Miriam Baca, Josh Kaminker, Zora Modrusan, Kimberly Scearce-Levie
Publikováno v:
Science translational medicine, vol 9, iss 403
Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined. We provide evidence that dual leucine zipper kinase (DLK) is a
Autor:
Jens Christian Schwamborn, Jared Sterneckert, York Rudhard, Susanne Höing, Peter Reinhardt, Martin Stehling, Mark Slack, Guangming Wu, Alexander Böcker, Juan A. Parga, Eva C. Bunk, Michael Glatza, Hans R. Schöler, Christiane Peiker
Publikováno v:
Cell Stem Cell. 11:620-632
SummaryStem cells, through their ability to both self-renew and differentiate, can produce a virtually limitless supply of specialized cells that behave comparably to primary cells. We took advantage of this property to develop an assay for small-mol
Autor:
Guillermo Federico Spitzmaul, Martijn Schonewille, William Wisden, Chris I. De Zeeuw, Patricia Seja, Thomas J. Jentsch, Ilse Klein, Aleksandra Badura, Christian A. Hübner, York Rudhard
Publikováno v:
The EMBO Journal. 31:1217-1230
Cerebellar cortical throughput involved in motor control comprises granule cells (GCs) and Purkinje cells (PCs), both of which receive inhibitory GABAergic input from interneurons. The GABAergic input to PCs is essential for learning and consolidatio
Autor:
Georg F. Rast, Cezar M. Tigaret, Ralf Schoepfer, Agnes Thalhammer, Christian G. Specht, York Rudhard
Publikováno v:
Molecular and Cellular Neuroscience. 28:326-334
alpha-Synuclein, a protein implicated in neurodegenerative diseases and of elusive physiological function owes its name to an observed presence in presynaptic and nuclear compartments. However, its nuclear localisation has remained controversial. We
Publikováno v:
Neuropharmacology. 35:1023-1028
The predicted major intracellular domains of the chick and rat neuronal nicotinic acetylcholine receptor alpha 7 subunits were expressed in E. coli as glutathione-S-transferase fusion proteins. These proteins were then purified to near homogeneity by
Autor:
Alexander J. Annala, Ralf Schoepfer, Christian G. Specht, Richard G. M. Morris, Timothy V. P. Bliss, Philip E. Chen, Cezar M. Tigaret, Guiquan Chen, M.L. Errington, Mohammed A. Nassar, Matthias Kneussel, York Rudhard, Georg F. Rast
Publikováno v:
Chen, P E, Errington, M L, Kneussel, M, Chen, G, Annala, A J, Rudhard, Y H, Rast, G F, Specht, C G, Tigaret, C M, Nassar, M A, Morris, R G M, Bliss, T V P & Schoepfer, R 2009, ' Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus ', Learning & Memory, vol. 16, no. 10, pp. 635-44 . https://doi.org/10.1101/lm.1316909
The NMDA receptor (NMDAR) subunit GluN1 is an obligatory component of NMDARs without a known functional homolog and is expressed in almost every neuronal cell type. The NMDAR system is a coincidence detector with critical roles in spatial learning an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd179e03f98f8af82173bf740c918bfb
Autor:
Elena B. Pasquale, Louise Gaitanos, Thomas Klopstock, Ralf Schoepfer, Maria A. Carmona, York Rudhard, Christine R. Rose, Ruediger Klein, Klas Kullander, Alessandro Filosa, Lore Becker, Silke D. Honsek, Berend Feddersen, Sónia Paixão
Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions, and EphA4-mediated ephrin rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca7616f00a24a28104250027f904ef5
https://europepmc.org/articles/PMC3922060/
https://europepmc.org/articles/PMC3922060/
Autor:
Ingo Kurth, Michaela Schweizer, Jaana Tyynelä, Sampsa T. Sipilä, Linda M. Laatikainen, Aleksi Haapanen, York Rudhard, Eva Ruusuvuori, Christian A. Hübner, Moritz Hentschke, Jeppe Praetorius, Helle Hasager Damkier, Juha Voipio, Stefan Jacobs
Publikováno v:
Jacobs, S, Ruusuvuori, E, Sipilä, S T, Haapanen, A, Damkier, H, Kurth, I, Hentschke, M, Schweizer, M, Rudhard, Y, Laatikainen, L M, Tyynelä, J, Prætorius, J, Voipio, J & Hübner, C A 2008, ' Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability ', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 1, pp. 311-6 .
Aarhus University
Aarhus University
Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na + -coupled Cl − –HCO 3 − exchanger Slc4a10 (NCBE), drastically reduces