Výsledky vyhledávání - "York A. Tomita"

BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells

Autor: Eliot M. Rosen, Shyam Nathan, Milton L. Brown, Eliseu O. De Oliveira, York A. Tomita, Yongxian Ma

We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e5108049e0f3c9d56b15e913222d55
https://europepmc.org/articles/PMC5681404/

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