Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Yorik B. Bruseker"'
1
Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors
Autor: Erik H. Heijne, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Rob Winkel, L. Babiss, Wendy van Bruggen, Louis Renzetti, Mark J. Mulvihill, Birgit Zech, Andrew J. McRiner, Johan J. N. Veerman, Eddy Damen, Yorik B. Bruseker, Heather A. Thomson, Julie Liu, Gerhard Müller, Koen F. W. Hekking, Ying Zhang, Peter van Rijnsbergen
Publikováno v: ACS Medicinal Chemistry Letters. 12:555-562
Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d65527e5f7e8fb6d40ba9c6dda27029
https://doi.org/10.1021/acsmedchemlett.0c00547
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2
Discovery of 2,4-1
Autor: Johan J N, Veerman, Yorik B, Bruseker, Eddy, Damen, Erik H, Heijne, Wendy, van Bruggen, Koen F W, Hekking, Rob, Winkel, Christopher D, Hupp, Anthony D, Keefe, Julie, Liu, Heather A, Thomson, Ying, Zhang, John W, Cuozzo, Andrew J, McRiner, Mark J, Mulvihill, Peter, van Rijnsbergen, Birgit, Zech, Louis M, Renzetti, Lee, Babiss, Gerhard, Müller
Publikováno v: ACS Med Chem Lett
[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12d9ec47ec0b7cafcb9e7a681001f5ae
https://pubmed.ncbi.nlm.nih.gov/33859795
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