A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model

Autor: Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, Hélène Baribault, Russell B. Fletcher

Publikováno v: Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)

Abstract Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human diseases such as idio

Externí odkaz: https://doaj.org/article/f27d31a51f9a492fa22352567892c341

BRAIDing receptors for cell-specific targeting

Autor: Hui Chen, Sung-Jin Lee, Ryan Li, Asmiti Sura, Nicholas Suen, Archana Dilip, Yan Pomogov, Meghah Vuppalapaty, Timothy T Suen, Chenggang Lu, Yorick Post, Yang Li

Publikováno v: eLife, Vol 12 (2024)

Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we have termed

Externí odkaz: https://doaj.org/article/b18a4fedb9594fe39bd8ab03b0fe2af9

Derivation of snake venom gland organoids for in vitro venom production

Autor: Nicholas R. Casewell, Mátyás A. Bittenbinder, Hans Clevers, Harald M. I. Kerkkamp, Jens Puschhof, Yorick Post, Freek J. Vonk, Joep Beumer, Michael K. Richardson

Publikováno v: Nature Protocols, 16(3), 1494-1510. Nature Publishing Group
Puschhof, J, Post, Y, Beumer, J, Kerkkamp, H M, Bittenbinder, M, Vonk, F J, Casewell, N R, Richardson, M K & Clevers, H 2021, ' Derivation of snake venom gland organoids for in vitro venom production ', Nature Protocols, vol. 16, no. 3, pp. 1494-1510 . https://doi.org/10.1038/s41596-020-00463-4

More than 400,000 people each year suffer adverse effects following bites from venomous snakes. However, snake venom is also a rich source of bioactive molecules with known or potential therapeutic applications. Manually ‘milking’ snakes is the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd30f8baead05384455572a94b2aa20
http://www.scopus.com/inward/record.url?scp=85099969454&partnerID=8YFLogxK

MODELING VERTEBRATE ADULT STEM CELLS AND THEIR PROGENY

Autor: Yorick Post

The adult human body consists of trillions of cells. These cells are the building blocks for every organ and tissue in the body. During our lifetime, cells are constantly lost at different speeds due to natural turnover or damage. Extreme examples in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c1c5ce11dd7488251e74e28597c6c1
https://doi.org/10.33540/143

Derivation of snake venom gland organoids for in vitro venom production

Autor: Jens, Puschhof, Yorick, Post, Joep, Beumer, Harald M, Kerkkamp, Matyas, Bittenbinder, Freek J, Vonk, Nicholas R, Casewell, Michael K, Richardson, Hans, Clevers

Publikováno v: Nature protocols. 16(3)

More than 400,000 people each year suffer adverse effects following bites from venomous snakes. However, snake venom is also a rich source of bioactive molecules with known or potential therapeutic applications. Manually 'milking' snakes is the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::869602f42a382c8552d0c421f085b83a
https://pubmed.ncbi.nlm.nih.gov/33504990