Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Yoram Zilberman"'
Autor:
Nadav Kimelman-Bleich, Zulma Gazit, Dan Gazit, Edward M. Schwarz, Yoram Zilberman, Gadi Pelled, Ayelet Ben Arav
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 6:e43-e50
Bone autografts are considered the gold standard for cranioplasty although they lead to comorbidity. Bone allografts are more easily obtained but have low osteogenic potential and fail to integrate into healthy bone. Previously, we showed that by coa
Autor:
Nadav Kimelman-Bleich, Samuela Rigozzi, Ralph Müller, Zulma Gazit, Dan Gazit, Yoram Zilberman, Jess G. Snedeker, Gadi Pelled, Ayelet Ben-Arav
Publikováno v:
Journal of Orthopaedic Research. 30:1932-1939
Tendon tissue regeneration is an important goal for orthopedic medicine. We hypothesized that implantation of Smad8/BMP2–engineered MSCs in a full-thickness defect of the Achilles tendon (AT) would induce regeneration of tissue with improved biomec
Autor:
Ilan Kallai, Yoram Zilberman, Olga Mizrahi, Zulma Gazit, Nadav Kimelman-Bleich, Dan Gazit, Gadi Pelled, Wafa Tawackoli
Publikováno v:
Molecular Therapy. 19:53-59
Nonunion fractures present a challenge to orthopedics with no optimal solution. In-vivo DNA electroporation is a gene-delivery technique that can potentially accelerate regenerative processes. We hypothesized that in vivo electroporation of an osteog
Autor:
Martin Rüthemann, Li Zhao, Olga Mizrahi, Linda E.A. Kanim, Yoram Zilberman, Hyun W. Bae, Ilan Kallai, Dan Gazit, Dima Sheyn, Gadi Pelled, Wafa Tawackoli, Jess G. Snedeker
Publikováno v:
Tissue Engineering Part A. 16:3679-3686
Most spine fusion procedures involve the use of prosthetic fixation devices combined with autologous bone grafts rather than biological treatment. We had shown that spine fusion could be achieved by injection of bone morphogenetic protein-2 (BMP-2)-e
Autor:
Davide Ruffoni, Dan Gazit, Yoram Zilberman, Gadi Pelled, Ilan Kallai, G. Harry van Lenthe, Ralph Müller
Publikováno v:
Journal of Biomechanics. 43:2315-2320
Stem cell-mediated gene therapy for fracture repair, utilizes genetically engineered mesenchymal stem cells (MSCs) for the induction of bone growth and is considered a promising approach in skeletal tissue regeneration. Previous studies have shown th
Autor:
Gil Navon, Hadassah Shinar, Keren Keinan-Adamsky, Galit Saar, Dan Gazit, Yoram Zilberman, Gadi Pelled
Publikováno v:
NMR in Biomedicine
NMR in Biomedicine; Vol 23
NMR in Biomedicine; Vol 23
In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (TDE), magnetization transfer contrast (MTC), and 1H
Publikováno v:
Journal of Dental Research. 88:45-50
The human body displays central circadian rhythms of activity. Recent findings suggest that peripheral tissues, such as bone, possess their own circadian clocks. Studies have shown that osteocalcin protein levels oscillate over a 24-hour period, yet
Autor:
Lakshmi S. Nair, Kuangshin Tai, Yoram Zilberman, Sangamesh G. Kumbar, Dan Gazit, Christine Ortiz, Gadi Pelled, Cato T. Laurencin, Dima Sheyn
Publikováno v:
Journal of Biomechanics. 40:399-411
Stem cell-based gene therapy and tissue engineering have been shown to be an efficient method for the regeneration of critical-sized bone defects. Despite being an area of active research over the last decade, no knowledge of the intrinsic ultrastruc
Publikováno v:
Journal of Neurosurgery: Spine. 3:47-52
Object. The authors hypothesized that spinal fusion can be achieved and monitored by using cell-mediated gene therapy. Mesenchymal stem cells (MSCs) genetically engineered to express recombinant human bone morphogenetic protein—2 (rhBMP-2) conditio
Autor:
Zulma Gazit, Dan Gazit, Yossi Gafni, Gadi Pelled, Yoram Zilberman, Hagit Yotvat, Christian Jorgensen, Florence Apparailly, Eithan Galun, Gadi Turgeman
Publikováno v:
Molecular Therapy. 9:587-595
Viral delivery of the therapeutic gene bone morphogenetic protein-2 (BMP-2) is a promising approach for bone regeneration. The human parvovirus adeno-associated virus (AAV) type 2 is considered one of the most encouraging viral vector systems because