Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Yoram Shechter"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 71 (2021)
A family of monomodified bovine serum albumin (BSA) linked to methotrexate (MTX) through a variety of spacers was prepared. All analogues were found to be prodrugs having low MTX-inhibitory potencies toward dihydrofolate reductase in a cell-free syst
Externí odkaz:
https://doaj.org/article/2bb39ed04d5d425fa5ed342d4d5f4f28
Autor:
Itzik Cooper, Orly Ravid, Daniel Rand, Dana Atrakchi, Chen Shemesh, Yael Bresler, Gili Ben-Nissan, Michal Sharon, Mati Fridkin, Yoram Shechter
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1557 (2021)
Human serum albumin (HSA) is efficiently taken up by cancer cells as a source of carbon and energy. In this study, we prepared a monomodified derivative of HSA covalently linked to an EDTA derivative and investigated its efficacy to shuttle weakly an
Externí odkaz:
https://doaj.org/article/4f960feba0fb4d50b065ec936642eb19
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158352 (2016)
In this study, we examined the possibility of introducing methotrexate (MTX) to the carboxylate rather than to the ε-amino side chains of proteins. We found that MTX-amino compounds covalently linked to the carboxylate moieties of macromolecules, un
Externí odkaz:
https://doaj.org/article/f850cb7c35c3403494eed9007f2ef101
Autor:
Michal Sharon, Orly Ravid, Gili Ben-Nissan, Yoram Shechter, Daniel Rand, Itzik Cooper, Dana Atrakchi, Yael Bresler, Mati Fridkin, Chen Shemesh
Publikováno v:
Pharmaceutics
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1557, p 1557 (2021)
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1557, p 1557 (2021)
Human serum albumin (HSA) is efficiently taken up by cancer cells as a source of carbon and energy. In this study, we prepared a monomodified derivative of HSA covalently linked to an EDTA derivative and investigated its efficacy to shuttle weakly an
Publikováno v:
Toxicology and Applied Pharmacology. 384:114782
Bleomycin is an anticancer antibiotic effective against a range of human malignancies. Yet its usefulness is limited by serious side effects. In this study, we converted bleomycin into a prodrug by covalently linking 2-sulfo, 9 fluorenylmethoxycarbon
Autor:
Itzik Cooper, David Last, David Guez, Shirley Sharabi, Shirin Elhaik Goldman, Irit Lubitz, Dianne Daniels, Sharona Salomon, Gregory Tamar, Tzur Tamir, Ronni Mardor, Mati Fridkin, Yoram Shechter, Yael Mardor
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 35:967-976
Despite aggressive therapy, existing treatments offer poor prognosis for glioblastoma multiforme patients, in part due to poor penetration of most drugs across the blood–brain barrier (BBB). We propose a minimal-invasive combined treatment approach
Autor:
Rona Limor, Yoram Shechter, Keren Sasson, Fortune Kohen, Matityahu Fridkin, Dafna Benayahu, Naftali Stern, Nava Nevo, Orit Pappo, Gabi Shefer, Michal Yacobi Bach, Inbal E. Biton, Tamara Berkutzki, Yonit Marcus
Publikováno v:
Diabetes. 62:1121-1130
We studied the effects of chronic angiotensin 1-7 (Ang 1-7) treatment in an experimental model of the metabolic syndrome, i.e., rats given high-fructose/low-magnesium diet (HFrD). Rats were fed on HFrD for 24 weeks with and without Ang 1-7 (576 µg/k
Autor:
Mati Fridkin, Menachem Rubinstein, Yoram Shechter, Vered Lev-Goldman, Sara Rubinraut, Keren Sasson
Publikováno v:
Bioconjugate Chemistry. 23:1577-1586
We found that human serum albumin (HSA) contains a single binding domain for derivatives of long-chain fatty acid (LCFA)-like molecules in which the carboxylate is replaced by sulfonate. Accordingly, we have synthesized 16-sulfo-hexadecanoic acid-N-h
Publikováno v:
Therapeutic Delivery. 3:17-23
Several important pharmacological features can be integrated into injected drugs to enhance their therapeutic efficacy following administration. Short-lived peptide/protein drugs should be converted into long-lived species in vivo to avoid multiple i
Publikováno v:
Journal of Controlled Release. 142:214-220
Here we describe the design and application of OSu-FMS-MAL-S-(CH(2))(15)-COOH, an agent that associates with albumin while linked to a peptide or a protein with sufficient affinity (Ka=2 to 2.6 x 10(5)M(-1)) to protract the action of short- lived pep