Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yoonjee Kim"'
Autor:
Kiyoung Lee, Yoonjee Kim
Publikováno v:
Nicotine & Tobacco Research. 23:1507-1511
Introduction The implementation of indoor smoke-free policy has compelled smokers to go outdoors to smoke. Outdoor smoking facilities were installed to designate outdoor smoking area. The purposes of the study were to identify factors of outdoor toba
Publikováno v:
Journal of the Korean Society for Research on Nicotine and Tobacco. 9:80-85
Publikováno v:
Korean Journal of Environmental Health Sciences. 43:267-272
Publikováno v:
Bulletin of the Korean Chemical Society. 34:759-762
Four prominent features of Titan's haze are found within the '3.4-' absorption to be uniform with recent vertically resolved Cassini/VIMS spectra. These are absorptions at 2998 (3.34 ), 2968 (3.37 ), 2927 (3.42 ), and 2882 (3.47 ). A detailed fitting
Autor:
Eun Joo Roh, Yoonjee Kim, Hyewhon Rhim, Ae Nim Pae, Munikumar Reddy Doddareddy, Jahyo Kang, Seon Hee Seo, Jae Kyun Lee, Jin-Kyu Choi, Eunjung Lee, Junghwan Park
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1409-1419
A series of compounds were designed as T-type calcium channel blocker containing 6 or 5 pharmacophore features from structure-based virtual screening. To optimize the suggested structure, over 130 derivatives were synthesized and their inhibitory act
Autor:
Hwa Sil Kim, Yong Seo Cho, Jinsung Tae, Hyunah Choo, Seon Hee Seo, Yoonjee Kim, Hyewhon Rhim, Munikumar Reddy Doddareddy, Ae Nim Pae
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:476-481
A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calc
Autor:
Yoonjee Kim, Min Joo Lee, Seong Jun Park, Bong Young Chung, Jae Yeol Lee, Hyewhon Rhim, Jung-Ha Lee, Sung Jun Park
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3502-3511
For the novel, potent, and selective T-type Ca 2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca 2+ channels. Among them, 9c ( KYS0506
Publikováno v:
Combinatorial chemistryhigh throughput screening. 12(3)
Whole-cell patch-clamp-based electrophysiological techniques are powerful tools for examining the biophysical and pharmacological properties of ion channels. However, the recent validation of ion channels as novel drug targets necessitates the develo
Autor:
Dong Jun Joo, Jungahn Kim, Jae Yeol Lee, Han Na Seo, Yoonjee Kim, So Ha Lee, Hyewhon Rhim, Ja Youn Choi, Yun Jeong Choe
Publikováno v:
ChemInform. 39
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compou
Autor:
Yun Jeong Choe, Han Na Seo, Jungahn Kim, So Ha Lee, Jae Yeol Lee, Yoonjee Kim, Dong Jun Joo, Ja Youn Choi, Hyewhon Rhim
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compou