Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Yoongho, Lim"'
Publikováno v:
Journal of Chemistry, Vol 2023 (2023)
Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19. Ten 3-(5-hydroxyphenyl)-5-phenyl-2-pyrazolines were tested using TLR7
Externí odkaz:
https://doaj.org/article/bb06daeaea2c401f8b8f85d06363e156
Publikováno v:
Journal of Chemistry, Vol 2022 (2022)
Chalcones have a skeleton of diphenyls connected via an α,β-unsaturated carbonyl group. Many chalcone derivatives have been shown to interact with tubulin. Based on previous reports, chalcones derived by substitution of a carbonyl group with 2-pyra
Externí odkaz:
https://doaj.org/article/5a184958bf3741a08289c16b2604cda7
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23:1156-1163
Introduction: Tubulin polymerization inhibitors induce cancer cell death; therefore, they can be developed as chemotherapeutic agents. We hypothesized that hybrid compounds, including the trans-stilbene moiety contained in resveratrol and penta-1,4-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5768f062c83ad789c846707a07a365
https://doi.org/10.2174/1871520623666230216091116
https://doi.org/10.2174/1871520623666230216091116
Autor:
Sung Shin Ahn, Hyunjin Yeo, Euitaek Jung, Sukjin Ou, Young Han Lee, Yoongho Lim, Soon Young Shin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14861 (2022)
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases accompanied by severe itching. β-caryophyllene (BCP), which displays anti-inflammatory activity, is a natural agonist of cannabinoid receptor 2. However, the therapeutic eff
Externí odkaz:
https://doaj.org/article/cad4e0cbd11747669db993396696df49
Publikováno v:
Molecules, Vol 27, Iss 13, p 4205 (2022)
The circadian clock system is closely associated with inflammatory responses. Dysregulation of the circadian clock genes in the skin impairs the skin barrier function and affects the pathophysiology of atopic dermatitis. Interleukin 4 (IL-4) is a pro
Externí odkaz:
https://doaj.org/article/5de21a113d86436a8cd0573275bdadac
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4857 (2022)
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide, characterized by intense pruritus and eczematous lesions. Aberrant expression of thymic stromal lymphopoietin (TSLP) in keratinocytes is associated with th
Externí odkaz:
https://doaj.org/article/cba214fa8d85494ab28450a7ff3885f7
Autor:
Yen Thi-Kim Nguyen, Ngoc Bao To, Vi Nguyen-Phuong Truong, Hee Young Kim, Meran Keshawa Ediriweera, Yoongho Lim, Somi Kim Cho
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 906 (2022)
Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for cancer treatment. Breast cancer stem cells (BCSCs) exert distinct metabolism machinery, which plays a major role in radiation and multidrug resistance. Therefor
Externí odkaz:
https://doaj.org/article/28fc98b0daaf4184b718e74a39d37194
Autor:
Jeong Yeon Lee, Sung Shin Ahn, You Jeong Jeong, Jihye Choi, Seunghyun Ahn, Dongsoo Koh, Young Han Lee, Yoongho Lim, Soon Young Shin
Publikováno v:
Journal of Chemistry, Vol 2020 (2020)
Aurora kinases are Ser/Thr kinases that function as mitotic regulators. 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one (DK1913) is a synthetic pan-Aurora kinase inhibitor. However, the mode of action of DK1913 concerning the induction of apo
Externí odkaz:
https://doaj.org/article/a56694ab02bb4a3392d0eac02ad1b18f
Autor:
Soon Young Shin, Euitaek Jung, Yoongho Lim, Ha-Jin Lee, Ji Hyun Rhee, Miri Yoo, Seunghyun Ahn, Dongsoo Koh
Publikováno v:
Crystals, Vol 12, Iss 1, p 108 (2022)
The flavone–chalcone hybrid compound, (E)-6-bromo-3-(3-(2-methoxyphenyl)-3-oxoprop-1-enyl)-4H-chromen-4-one (3), was synthesized and its three dimensional structure was identified by X-ray crystallography. The compound 3, C19H13BrO4, was crystalliz
Externí odkaz:
https://doaj.org/article/c575f53a3f794cbe914a9a8386249a05
Supplementary Data from Transcription Factor Egr-1 Is Essential for Maximal Matrix Metalloproteinase-9 Transcription by Tumor Necrosis Factor α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767160ae57f1a5c5e19342f5575134a7
https://doi.org/10.1158/1541-7786.22519323.v1
https://doi.org/10.1158/1541-7786.22519323.v1
