Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy.

Autor: Kim SY; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Im JY; SmartinBio Inc., Cheongju, 28160, Republic of Korea., Lee JH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Kim J; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Jeon Y; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Choi YJ; Bioanalysis and Pharmacokinetics Research Group, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea., Lee JH; Bioanalysis and Pharmacokinetics Research Group, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.; Department of Human and Environment Toxicology, University of Science & Technology, Daejeon, 34113, Republic of Korea., Uemura A; Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan., Park DH; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.; Cell & Matrix Research Institute, Kyungpook National University, Daegu, 41944, Republic of Korea., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; SmartinBio Inc., Cheongju, 28160, Republic of Korea.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jan; Vol. 11 (2), pp. e2302776. Date of Electronic Publication: 2023 Nov 20.

Correction to "Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site".

Autor: Yoon NG, Lee H, Kim SY, Hu S, Kim D, Yang S, Hong KB, Lee JH, Kang S, Kim BG, Myung K, Lee C, Kang BH

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Feb 02; Vol. 144 (4), pp. 2020. Date of Electronic Publication: 2022 Jan 19.

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.

Autor: Yang S; College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea., Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Kim D; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Park E; College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea., Kim SY; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Lee JH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Lee C; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Kang S; College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jun 16; Vol. 12 (7), pp. 1173-1180. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).

Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug.

Autor: Hu S; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Ferraro M; Istituto di Chimica del Riconoscimento Molecolare (ICRM), Consiglio Nazionale delle Ricerche (CNR), Milan 20131, Italy., Thomas AP; Department of Chemistry, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Chung JM; Division of Chemistry and Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea., Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Seol JH; Department of Chemistry, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Kim S; Department of Chemistry, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Kim HU; Division of Chemistry and Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea., An MY; Division of Chemistry and Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea., Ok H; Department of Chemistry, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Jung HS; Division of Chemistry and Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea., Ryu JH; Department of Chemistry, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Colombo G; University of Pavia, Department of Chemistry, Pavia 27100, Italy., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2930-2940. Date of Electronic Publication: 2020 Mar 02.

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.

Autor: Park HK; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea. hkparkgene@unist.ac.kr., Yoon NG; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Lee JE; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Hu S; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Yoon S; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Kim SY; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Hong JH; Rare Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, 10408, Republic of Korea., Nam D; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Chae YC; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Park JB; Rare Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, 10408, Republic of Korea.; Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea. kangbh@unist.ac.kr.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2020 Jan; Vol. 52 (1), pp. 79-91. Date of Electronic Publication: 2020 Jan 20.