Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yoon Keun Cho"'
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102039- (2024)
Objective: Adipose tissue remodeling plays a critical role in obesity-induced metabolic dysfunction, but the underlying molecular mechanisms remain incompletely understood. This study investigates the role of miR-10a-5p in adipose tissue inflammation
Externí odkaz:
https://doaj.org/article/1d4b0a2b8b56405c8b8ca7f4f7103b6d
Autor:
Yoon Keun Cho, Sumin Lee, Jaewon Lee, Junsang Doh, Joo-Hong Park, Young-Suk Jung, Yun-Hee Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1955-1973 (2023)
Abstract Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipos
Externí odkaz:
https://doaj.org/article/13c9865b926447be8dd607789f298fe8
Autor:
Yoon Keun Cho, Young Cheol Yoon, Hyeonyeong Im, Yeonho Son, Minsu Kim, Abhirup Saha, Cheoljun Choi, Jaewon Lee, Sumin Lee, Jae Hyun Kim, Yun Pyo Kang, Young-Suk Jung, Hong Koo Ha, Je Kyung Seong, James G. Granneman, Sung Won Kwon, Yun-Hee Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Dysregulation of plasmalogen metabolism in adipose tissue is associated with metabolic diseases. Here the authors characterize the role of adipocyte TMEM86A as a lysoplasmalogenase and show its deletion is protective against high fat diet induced met
Externí odkaz:
https://doaj.org/article/2c56b34324264a9f91f13814bde9ec28
Autor:
Yeonho Son, Cheoljun Choi, Cheol Song, Hyeonyeong Im, Yoon Keun Cho, Ju Seung Son, Sungug Joo, Yoonjoe Joh, Young Jae Lee, Je Kyung Seong, Yun-Hee Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cell death-inducing DNA fragmentation factor-like effector A (CIDEA) is a lipid droplet-associated protein and is a known marker of the thermogenic capacity of brown/beige adipocytes. To monitor the expression of CIDEA in live mice in a non-
Externí odkaz:
https://doaj.org/article/b8ad4613a74f4a8b8b944e3624538d61
Autor:
Cheoljun Choi, Abhirup Saha, Seungchan An, Yoon Keun Cho, Heeseong Kim, Minsoo Noh, Yun-Hee Lee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Adipose tissue macrophages are a major immune cell type contributing to homeostatic maintenance and pathological adipose tissue remodeling. However, the mechanisms underlying macrophage recruitment and polarization in adipose tissue during obesity re
Externí odkaz:
https://doaj.org/article/8f42ceb729294492ad7b57245b666806
MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling
Autor:
Yoon Keun Cho, Yeonho Son, Sang-Nam Kim, Hyun-Doo Song, Minsu Kim, Ji-Hyun Park, Young-Suk Jung, Sang-Yeop Ahn, Abhirup Saha, James G. Granneman, Yun-Hee Lee
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 86-98 (2019)
Objective: This study investigated the role of microRNAs generated from adipose tissue macrophages (ATMs) during adipose tissue remodeling induced by pharmacological and nutritional stimuli. Methods: Macrophage-specific Dicer knockout (KO) mice were
Externí odkaz:
https://doaj.org/article/9ca3c8ec8d104219b3a36053a453e9d7
Autor:
Yeonho Son, Yoon Keun Cho, Abhirup Saha, Hyun-Jung Kwon, Ji-Hyun Park, Minsu Kim, Young-Suk Jung, Sang-Nam Kim, Cheoljun Choi, Je-Kyung Seong, Rayanne B. Burl, James G. Granneman, Yun-Hee Lee
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp - (2020)
Objective: Beclin1 is a core molecule of the macroautophagy machinery. Although dysregulation of macroautophagy is known to be involved in metabolic disorders, the function of Beclin1 in adipocyte metabolism has not been investigated. In the present
Externí odkaz:
https://doaj.org/article/82166b24af1f4c1a8349cf9455e1c9c9
Autor:
Minsu Kim, Seowoo Im, Yoon keun Cho, Cheoljun Choi, Yeonho Son, Doyoung Kwon, Young-Suk Jung, Yun-Hee Lee
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1394 (2020)
Soy isoflavones are bioactive phytoestrogens with known health benefits. Soybean embryo extract (SEE) has been consumed as a source of isoflavones, mainly daidzein, glycitein, and genistein. While previous studies have reported the anti-obesity effec
Externí odkaz:
https://doaj.org/article/145e4dc5831e4d28ba7734b8d26ad73a
Autor:
Juhyeong Han, Young Suk Jung, Ji Hyun Park, Abhirup Saha, James G. Granneman, Minsu Kim, Jeanho Yun, Sangkyu Lee, Cheoljun Choi, Kyung-Min Kim, Yeonho Son, Eun Ju Bae, Yoon Keun Cho, Yun Hee Lee, Doeun Kim, Hyeonyeong Im, Mi-Ock Lee, Je Kyung Seong
Publikováno v:
Nature Metabolism. 3:428-441
Obesity reduces adipocyte mitochondrial function, and expanding adipocyte oxidative capacity is an emerging strategy to improve systemic metabolism. Here, we report that serine/threonine-protein kinase 3 (STK3) and STK4 are key physiological suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64e3097e6cee2e9f518d62414f7fb2
https://doi.org/10.1038/s42255-021-00362-2
https://doi.org/10.1038/s42255-021-00362-2
Autor:
Hyun Jung Kwon, Abhirup Saha, Minsu Kim, Yeonho Son, Woo Ram Yang, Jin Hyun Jeong, Je Kyung Seong, Yun Hee Lee, Young Suk Jung, Yoon Keun Cho, Sang Yeop Ahn
Publikováno v:
International Journal of Obesity. 45:122-129
Polymethoxyselenoflavone (PMSF) is a compound that substitutes the oxygen atom in a flavonoid with selenium. This study aimed to investigate the effects of PMSFs on lipid metabolism in adipocytes and their anti-obesity potential. To test lipolytic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696221611e0de3cbd076b7dd37fc516d
https://doi.org/10.1038/s41366-020-0606-7
https://doi.org/10.1038/s41366-020-0606-7