Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington’s Disease

Autor: Zhuowei Du, Margot Tertrais, Gilles Courtand, Thierry Leste-Lasserre, Laura Cardoit, Frédérique Masmejean, Christophe Halgand, Yoon H. Cho, Maurice Garret

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor symptoms that are preceded by cognitive deficits and is considered as a disorder that primarily affects forebrain striatal neurons. To gain a better unders

Externí odkaz: https://doaj.org/article/cc59dde7c5364244bf3fa852e675ef18

Changes in striatal activity and functional connectivity in a mouse model of Huntington's disease.

Autor: Magali Cabanas, Fares Bassil, Nicole Mons, Maurice Garret, Yoon H Cho

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184580 (2017)

Hereditary Huntington's disease (HD) is associated with progressive motor, cognitive and psychiatric symptoms. A primary consequence of the HD mutation is the preferential loss of medium spiny projection cells with relative sparing of local interneur

Externí odkaz: https://doaj.org/article/90510fca95d9418b8e8f56d4452e62f8

β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement

Autor: Marianne Husson, Léa Tochon, Inés Ibañez-Tallon, Lauriane Harrington, Yoon H. Cho, Uwe Maskos, Vincent David

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2020, 40 (17), pp.3465-3477. ⟨10.1523/JNEUROSCI.0356-19.2020⟩
J Neurosci
Journal of Neuroscience, Society for Neuroscience, 2020, 40 (17), pp.3465-3477. ⟨10.1523/JNEUROSCI.0356-19.2020⟩

Nicotine addiction, through smoking, is the principal cause of preventable mortality worldwide. Human genome-wide association studies have linked polymorphisms in theCHRNA5-CHRNA3-CHRNB4gene cluster, coding for the α5, α3, and β4 nicotinic acetylc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2847222a685eaa4da6dfd3bdd9b7f6a
https://doi.org/10.1523/jneurosci.0356-19.2020

β oscillation during slow wave sleep and rapid eye movement sleep in the electroencephalogram of a transgenic mouse model of Huntington's disease.

Autor: Yannick Jeantet, Sebastien Cayzac, Yoon H Cho

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79509 (2013)

STUDY OBJECTIVES: To search for early abnormalities in electroencephalogram (EEG) during sleep which may precede motor symptoms in a transgenic mouse model of hereditary neurodegenerative Huntington's disease (HD). DESIGN: In the R6/1 transgenic mous

Externí odkaz: https://doaj.org/article/8aa6d16518ce4663aedbe56dd5c850e6

Omics analysis of mouse brain models of human diseases

Autor: Elodie Mansour, Béatrice Alescio-Lautier, Yoon H. Cho, Veronique Paban, Sylvie Gory-Fauré, Susanna Pietropaolo, David Blum, Claude Villard, Béatrice Loriod, Ali Gharbi, Luc Buée

Publikováno v: Gene
Gene, Elsevier, 2016, 600, pp.90-100. ⟨10.1016/j.gene.2016.11.022⟩
Gene, 2016, 600, pp.90-100. ⟨10.1016/j.gene.2016.11.022⟩

International audience; The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate theconvergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse linesmodelling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4422330a931448b368706cd5ba73b8ba
https://doi.org/10.1016/j.gene.2016.11.022