Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yoolim A. Choi"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Rare or de novo variants have substantial contribution to human diseases, but the statistical power to identify risk genes by rare variants is generally low due to rarity of genotype data. Previous studies have shown that risk genes usually
Externí odkaz:
https://doaj.org/article/88d6a4498f9a4d638553e3aeafaf1a2d
We present VBASS, a Bayesian method that integrates single-cell expression and de novo variant (DNV) data to improve power of disease risk gene discovery. VBASS models disease risk prior as a function of expression profiles, approximated by deep neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b546b2e4766f0ce7bc69a1dfe9efac
https://doi.org/10.1101/2022.05.13.491893
https://doi.org/10.1101/2022.05.13.491893
Autor:
Sarah Naomi Olsen, Laura Godfrey, James P. Healy, Yoolim A. Choi, Yan Kai, Charles Hatton, Florian Perner, Elena L. Haarer, Behnam Nabet, Guo-Cheng Yuan, Scott A. Armstrong
Publikováno v:
Mol Cell
MLL-rearrangements produce fusion oncoproteins that drive leukemia development, but the direct effects of MLL-fusion inactivation remain poorly defined. We designed models with degradable MLL::AF9 where treatment with small molecules induces rapid de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25b00ba7e77f95f042a7b78f2e78c9c
https://doi.org/10.1016/j.molcel.2022.02.013
https://doi.org/10.1016/j.molcel.2022.02.013
Autor:
Chen, Cao, Laurence A, Lemaire, Wei, Wang, Peter H, Yoon, Yoolim A, Choi, Lance R, Parsons, John C, Matese, Michael, Levine, Kai, Chen
Publikováno v:
Nature. 571(7765)
Ascidian embryos highlight the importance of cell lineages in animal development. As simple proto-vertebrates, they also provide insights into the evolutionary origins of cell types such as cranial placodes and neural crest cells. Here we have determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2206eda1b924b3c3ee37d544e52e069
https://pubmed.ncbi.nlm.nih.gov/31308528
https://pubmed.ncbi.nlm.nih.gov/31308528