Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Yool Lee"'
Autor:
Prajakta Vaishampayan, Yool Lee
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103288- (2024)
Pharmacological vitamin C (VC) has gained attention for its pro-oxidant characteristics and selective ability to induce cancer cell death. However, defining its role in cancer has been challenging due to its complex redox properties. In this study, u
Externí odkaz:
https://doaj.org/article/4bb26a4d4d4d4d678808eeb5e4aa376e
Autor:
Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang, Hongguang Shao, Harsh Dweep, Yao-Yu Gong, Rebekah Brooks, Patricia Brafford, Adam J. Wolpaw, Yool Lee, Ashani Weeraratna, Amita Sehgal, Meenhard Herlyn, Andrew Kossenkov, David Speicher, Peter K. Sorger, Sandro Santagata, Chi V. Dang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells
Externí odkaz:
https://doaj.org/article/c859ff64da1345c9ad8da5b07e20c424
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283463 (2023)
The molecular circadian clock is regulated by a transcriptional translational feedback loop. However, the post-translational control mechanisms are less understood. The NRON complex is a large ribonucleoprotein complex, consisting of a lncRNA and sev
Externí odkaz:
https://doaj.org/article/4133a8b46e444ac791d5fec223d95d70
Autor:
Yool Lee, Alfian Shan Tanggono
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14181 (2022)
Circadian rhythms, including sleep/wake cycles as well as hormonal, immune, metabolic, and cell proliferation rhythms, are fundamental biological processes driven by a cellular time-keeping system called the circadian clock. Disruptions in these rhyt
Externí odkaz:
https://doaj.org/article/a6bcef6f578b4b9bb596ae297e35ecc0
Publikováno v:
Revista Cubana de Investigaciones Biomédicas, Vol 38, Iss 5 (2020)
Introduction: While the circadian clock has been characterized in systemic blood vessels and well established to contribute to various inflammatory pathologies associated with the endothelium, the mechanisms of circadian control of endothelial inflam
Externí odkaz:
https://doaj.org/article/e58754adfd404c9782be910096dcf90a
Autor:
Lei Bai, Yool Lee, Cynthia T. Hsu, Julie A. Williams, Daniel Cavanaugh, Xiangzhong Zheng, Carly Stein, Paula Haynes, Han Wang, David H. Gutmann, Amita Sehgal
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3416-3426 (2018)
Summary: Loss of the Neurofibromatosis 1 (Nf1) protein, neurofibromin, in Drosophila disrupts circadian rhythms of locomotor activity without impairing central clock function, suggesting effects downstream of the clock. However, the relevant cellular
Externí odkaz:
https://doaj.org/article/8301806842e040a1af46544800c5ff40
Autor:
Yool Lee, Jonathan P. Wisor
Publikováno v:
Biology, Vol 11, Iss 1, p 21 (2021)
The circadian clock is a fundamental biological timing mechanism that generates nearly 24 h rhythms of physiology and behaviors, including sleep/wake cycles, hormone secretion, and metabolism. Evolutionarily, the endogenous clock is thought to confer
Externí odkaz:
https://doaj.org/article/b181f57c32b04fff928cf52b94be6400
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000228 (2019)
Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms, we subjected transformed cultured cells to chronic circadian desynchrony (CCD), mimicking a chronic jet-lag sc
Externí odkaz:
https://doaj.org/article/fe6d90c5e4114123872785893ace9b2d
Publikováno v:
Endocrinology and Metabolism, Vol 29, Iss 3, Pp 379-387 (2014)
BackgroundIn mammals, the CLOCK/BMAL1 heterodimer is a key transcription factor complex that drives the cyclic expression of clock-controlled genes involved in various physiological functions and behavioral consequences. Recently, a growing number of
Externí odkaz:
https://doaj.org/article/dbdcb71f982145e0922b190dd0ec2e11
Publikováno v:
eLife, Vol 4 (2015)
Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood. Here, we report that KPNB1, an importin
Externí odkaz:
https://doaj.org/article/472caef13fc74842b0e9e1512f8fbafe