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Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury.

Autor: Yonutas HM; Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA. Electronic address: heather.yonutas@yahoo.com., Hubbard WB; Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Lexington VA Healthcare System, Lexington, KY 40502, USA. Electronic address: bradhubbard@uky.edu., Pandya JD; Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Currently Research Biologist, Brain Trauma Neuroprotection and Neurorestoration (BTNN) Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA. Electronic address: jignesh.d.pandya.civ@mail.mil., Vekaria HJ; Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA. Electronic address: hemendravekaria@uky.edu., Geldenhuys WJ; Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown 26501, USA. Electronic address: werner.geldenhuys@hsc.wvu.edu., Sullivan PG; Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Lexington VA Healthcare System, Lexington, KY 40502, USA. Electronic address: patsullivan@uky.edu.

Publikováno v: Experimental neurology [Exp Neurol] 2020 May; Vol. 327, pp. 113243. Date of Electronic Publication: 2020 Feb 10.

Identification of small molecules that bind to the mitochondrial protein mitoNEET.

Autor: Geldenhuys WJ; Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, USA. Electronic address: werner.geldenhuys@hsc.wvu.edu., Yonutas HM; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA., Morris DL; Department of Chemistry and Biochemistry, University of Akron, Akron, OH 44325, USA., Sullivan PG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA., Darvesh AS; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44240, USA., Leeper TC; Department of Chemistry and Biochemistry, University of Akron, Akron, OH 44325, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Nov 01; Vol. 26 (21), pp. 5350-5353. Date of Electronic Publication: 2016 Sep 06.

Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging.

Autor: Pandya JD; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Grondin R; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Yonutas HM; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Haghnazar H; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Gash DM; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Zhang Z; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA., Sullivan PG; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA. Electronic address: patsull@uky.edu.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2015 May; Vol. 36 (5), pp. 1903-13. Date of Electronic Publication: 2015 Jan 28.

N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.

Autor: Pandya JD; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536., Readnower RD; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536., Patel SP; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Physiology, University of Kentucky, Lexington, KY 40536., Yonutas HM; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536., Pauly JR; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536., Goldstein GA; Pediatric Endocrinology Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Rabchevsky AG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Physiology, University of Kentucky, Lexington, KY 40536., Sullivan PG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536; Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536. Electronic address: Patsull@uky.edu.

Publikováno v: Experimental neurology [Exp Neurol] 2014 Jul; Vol. 257, pp. 106-13. Date of Electronic Publication: 2014 May 01.