Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yonka Christova"'
Publikováno v:
Biology Open, Vol 3, Iss 12, Pp 1151-1157 (2014)
iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spon
Externí odkaz:
https://doaj.org/article/3e93e1f0130c476696bde63666f635ae
Autor:
Sarah L. Maslen, Salvador Buse, Martin Spinck, Louise F. H. Funke, Daniel de la Torre, George P. C. Salmond, Wesley E. Robertson, Thomas S. Elliott, Franz L. Böge, Daniele Cervettini, Julius Fredens, Jason W. Chin, Yonka Christova, Kim C. Liu
Publikováno v:
Science. 372:1057-1062
Designing bacterial superpowers Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers
Loss of iRhom2, a catalytically inactive rhomboid‐like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2‐null mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d29cb2f79667162ad503d6fd5ba6f43
https://ora.ox.ac.uk/objects/uuid:44155e69-aa8f-4b0d-a4ed-d45bef937127
https://ora.ox.ac.uk/objects/uuid:44155e69-aa8f-4b0d-a4ed-d45bef937127
Autor:
Václav Beránek, Yonka Christova, Daniel L. Dunkelmann, Tiongsun Chia, Andres Gonzalez Llamazares, Chayasith Uttamapinant, Louise F. H. Funke, Daniel de la Torre, Wolfgang H. Schmied, Jason W. Chin, Kaihang Wang, Julius Fredens, Wesley E. Robertson, Thomas S. Elliott
Publikováno v:
Nature. 569(7757)
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1 sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon choice has diverse and important roles, and many synonymous substitutions are
Autor:
Steven H. L. Verhelst, Matthew Freeman, Kvido Strisovsky, Antonina Andreeva, Yonka Christova, Kutti R. Vinothkumar
Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular signalling, parasitic invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fad81829f7abca2ec0124e26170bd5
https://ora.ox.ac.uk/objects/uuid:69d374bb-c0a3-4ae0-ab09-b652c86fb443
https://ora.ox.ac.uk/objects/uuid:69d374bb-c0a3-4ae0-ab09-b652c86fb443
Autor:
Jonathan M. Large, Ela Smiljanic, Kvido Strisovsky, Nathalie Bouloc, Matthew Freeman, Keith H. Ansell, Olivier A. Pierrat, Yonka Christova
Publikováno v:
ACS Chemical Biology
Rhomboids are relatively recently discovered intramembrane serine proteases that are conserved throughout evolution. They have a wide range of biological functions, and there is also much speculation about their potential medical relevance. Although
Publikováno v:
Biology Open
Biology Open, Vol 3, Iss 12, Pp 1151-1157 (2014)
Biology Open, Vol 3, Iss 12, Pp 1151-1157 (2014)
iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spon
Publikováno v:
Molecular Reproduction and Development. 68:365-372
Unsaturated lipids in sperm plasma membranes are very susceptible to peroxidation when exposed to reactive oxygen species (ROS). In this investigation we have incubated ram spermatozoa in the presence of two ROS generating systems, ascorbate/FeSO4 an
Publikováno v:
Molecular and Cellular Endocrinology. 216:41-46
Fluorescence recovery after photobleaching (FRAP) analysis has been used to measure lipid diffusion in different regions of the sperm plasma membrane. Our goal has been to understand how some membrane components are confined to specific surface domai
Autor:
Shab Ladha, Yonka Christova, Peter S. James, Caroline A. Wolfe, A. Patrick Gunning, Roy Jones
Publikováno v:
Molecular Reproduction and Development. 59:306-313
Seminal plasma proteins and macromolecules in the external medium have a major influence on the functionality of sperm plasma membranes. In this investigation we have examined their effects on lipid diffusion in the surface membrane of ram and bull s