Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yongzhao Huang"'
Autor:
John D. Belcher, Selvaraj Nataraja, Fuad Abdulla, Ping Zhang, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Maneet Singh, Shilpa Demes, Lyndsay Olson, Domi Stickens, Jeff Stanwix, Emer Clarke, Yongzhao Huang, Margaret Biddle, Gregory M. Vercellotti
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
In sickle cell disease (SCD), heme released during intravascular hemolysis promotes oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate expression of antioxidant and globin genes. Heme binds to the transcriptio
Externí odkaz:
https://doaj.org/article/08d36bbf537a4d62b4156a1ffb787feb
Autor:
Ying-Zhang Chen, Sayed H. Hashemi, Susan K. Anderson, Yongzhao Huang, Maria-Ceu Moreira, David R. Lynch, Ian A. Glass, Phillip F. Chance, Craig L. Bennett
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 97-108 (2006)
A severe recessive cerebellar ataxia, Ataxia-Oculomotor Apraxia 2 (AOA2) and a juvenile onset form of dominant amyotrophic lateral sclerosis (ALS4) result from mutations of the Senataxin (SETX) gene. To begin characterization this disease protein, we
Externí odkaz:
https://doaj.org/article/9f5332fe512346c7b1ba5bd6a05a46a1
Autor:
Selva Nataraja, Jeff Stanwix, Fuad Abdulla, Shilpa Demes, Emer Clarke, Maneet Singh, Julia Nguyen, Chunsheng Chen, John D. Belcher, Gregory M. Vercellotti, Margaret Biddle, Yongzhao Huang, Ping Zhang, Lyndsay Olson
Publikováno v:
Blood. 138:854-854
Sickle cell disease (SCD) is a genetic disorder caused by a point mutation in the β-globin subunit resulting in hemoglobin S (HbS). Following deoxygenation of red blood cells, HbS forms polymers that can promote hemolysis and the release of free hem
Autor:
Haijuan Du, Erica Walters, Timothy C. Cox, Michael A. Massiah, Yongzhao Huang, Manar Zaghlula
Publikováno v:
Journal of Biological Chemistry. 288:21341-21350
Alpha4 (α4) is a key regulator of protein phosphatase 2A (PP2A) and mTOR in steps essential for cell-cycle progression. α4 forms a complex with PP2A and MID1, a microtubule-associated ubiquitin E3 ligase that facilitates MID1-dependent regulation o
Autor:
Yongzhao Huang, Craig L. Bennett, Ian A. Glass, Sayed H. Hashemi, Phillip F. Chance, David A. Lynch, Ying Zhang Chen, Maria-Ceu Moreira, Susan K. Anderson
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 97-108 (2006)
A severe recessive cerebellar ataxia, Ataxia-Oculomotor Apraxia 2 (AOA2) and a juvenile onset form of dominant amyotrophic lateral sclerosis (ALS4) result from mutations of the Senataxin (SETX) gene. To begin characterization this disease protein, we
Publikováno v:
Journal of Biological Chemistry. 277:19889-19896
We have studied the function of protein kinase A (PKA) during embryonic development using a PKA-deficient mouse that retains only one functional catalytic subunit allele, either Calpha or Cbeta, of PKA. The reduced PKA activity results in neural tube
Publikováno v:
Proceedings of the National Academy of Sciences. 94:12515-12520
The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential very early in eye development, prior to facet assembly, to limit the number of photoreceptor cells in each facet of the compound ey
Publikováno v:
Science. 270:1828-1831
Ubiquitin is a highly conserved polypeptide found in all eukaryotes. The major function of ubiquitin is to target proteins for complete or partial degradation by a multisubunit protein complex called the proteasome. Here, the Drosophila fat facets ge
Autor:
Yongzhao Huang, Craig L. Bennett
Publikováno v:
Inflammatory bowel diseases. 13(1)
Autor:
Bjørn S. Skålhegg, G. Stanley McKnight, Thomas Su, Rejean L. Idzerda, Yongzhao Huang, Kimberly A. Burton
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 16(3)
The intracellular second messenger cAMP affects cell physiology by directly interacting with effector molecules that include cyclic nucleotide-gated ion channels, cAMP-regulated G protein exchange factors, and cAMP-dependent protein kinases (PKA). Tw