Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Yongxuan Su"'
Publikováno v:
Marine Drugs, Vol 21, Iss 8, p 446 (2023)
Petrosamine (1)—a colored pyridoacridine alkaloid from the Belizean sponge, Petrosia sp., that is also a potent inhibitor of acetylcholine esterase (AChE)—was investigated by spectroscopic and computational methods. Analysis of the petrosamine-fr
Externí odkaz:
https://doaj.org/article/15180bbcc43c4836958af6b34e266ac4
Autor:
Pep Charusanti, Nicole L Fong, Harish Nagarajan, Alban R Pereira, Howard J Li, Elisa A Abate, Yongxuan Su, William H Gerwick, Bernhard O Palsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33727 (2012)
Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance. We present a method here that, in contrast, exploits the power of adaptation
Externí odkaz:
https://doaj.org/article/53a6a25478864a928d8dbb417d83efb0
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
Rate of efflux of APTO-253 and Fe(253)3 from Raji and Raji/253R cells over first 2 hours (log fmole/10^7 cells/h)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c27f4f10ab997aa7b486eddfd07da0
https://doi.org/10.1158/1535-7163.22504885.v1
https://doi.org/10.1158/1535-7163.22504885.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
The accumulation of phospho-ATM, γ-H2AFX and cleaved PARP in Raji compared to that in Raji/253R cells exposed to APTO-253 for 24 h.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3504cab9cf4a75ff11104f10ec2bc80f
https://doi.org/10.1158/1535-7163.22504894.v1
https://doi.org/10.1158/1535-7163.22504894.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
Chemical Synthesis of APTO-253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d32be7be7fa0a83442af8fa0ee38a6b
https://doi.org/10.1158/1535-7163.22504888.v1
https://doi.org/10.1158/1535-7163.22504888.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
APTO-253 is a small molecule with antiproliferative activity against cell lines derived from a wide range of human malignancies. We sought to determine the mechanisms of action and basis for resistance to APTO-253 so as to identify synthetic lethal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4b3c27bf0c793db2d17ac380d0ae6c
https://doi.org/10.1158/1535-7163.c.6537886.v1
https://doi.org/10.1158/1535-7163.c.6537886.v1
Autor:
Ernesto Beltrán-Partida, Nayelli Nájera-García, Israel Ramirez-Sanchez, Guillermo Ceballos, Francisco Villarreal, Marcela Hernández, Theodore P. Ciaraldi, Aldo Moreno-Ulloa, Pam R. Taub, Robert R. Henry, Brookie M. Best, Yongxuan Su, George F. Schreiner, Sundeep Dugar
Publikováno v:
Food & Function. 9:307-319
We reported that (-)-epicatechin can stimulate mitochondria biogenesis and improve metabolism. However, preliminary studies indicate that the (+) stereoisomer form may be more potent. We evaluated in a preliminary manner, the pharmacokinetics (PK) an
Autor:
Stephen B. Howell, Cheng-Yu Tsai, Yongxuan Su, Larry A. Gross, Hongying Zhang, Si Sun, William G. Rice, Andrea Local
Publikováno v:
Molecular cancer therapeutics, vol 17, iss 6
Tsai, CY; Sun, S; Zhang, H; Local, A; Su, Y; Gross, LA; et al.(2018). APTO-253 is a new addition to the repertoire of drugs that can exploit DNA BRCA1/2 Deficiency. Molecular Cancer Therapeutics, 17(6), 1167-1176. doi: 10.1158/1535-7163.MCT-17-0834. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1554s9rx
Tsai, CY; Sun, S; Zhang, H; Local, A; Su, Y; Gross, LA; et al.(2018). APTO-253 is a new addition to the repertoire of drugs that can exploit DNA BRCA1/2 Deficiency. Molecular Cancer Therapeutics, 17(6), 1167-1176. doi: 10.1158/1535-7163.MCT-17-0834. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1554s9rx
APTO-253 is a small molecule with antiproliferative activity against cell lines derived from a wide range of human malignancies. We sought to determine the mechanisms of action and basis for resistance to APTO-253 so as to identify synthetic lethal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd5aefb787497a0fb5f0e067575d955
https://escholarship.org/uc/item/1554s9rx
https://escholarship.org/uc/item/1554s9rx
Autor:
George F. Schreiner, Aldo Moreno-Ulloa, Guillermo Ceballos, Yongxuan Su, Israel Ramirez-Sanchez, Sundeep Dugar, Francisco Villarreal, Christopher Barnett, Sruti Shiva, Pam R. Taub
Publikováno v:
Food & Function. 6:824-833
(-)-Epicatechin ((-)-EPI), a naturally occurring flavanol, has emerged as a likely candidate for cocoa-based product reported reductions in cardiometabolic risk. The present study aimed to determine the safety, tolerability, pharmacokinetics and phar
Publikováno v:
BJU International. 114:286-293
Objectives To identify and characterise urinary cationic metabolites, defined as toxic factors, in patients with interstitial cystitis (IC) and in control subjects. To evaluate the cytotoxicity of the urinary cationic metabolite fraction of patients