Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Yongxu Lu"'
Autor:
Pengtao Jiao, Jianing Ma, Yuna Zhao, Xiaoxiao Jia, Haoran Zhang, Wenhui Fan, Xiaojuan Jia, Xiaoyuan Bai, Yiqi Zhao, Yongxu Lu, He Zhang, Jiayin Guo, Gang Pang, Ke Zhang, Min Fang, Minghua Li, Wenjun Liu, Geoffrey L. Smith, Lei Sun
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
The Orthopoxvirus (OPXV) genus of the Poxviridae includes human pathogens variola virus (VARV), monkeypox virus (MPXV), vaccinia virus (VACV), and a number of zoonotic viruses. A number of Bcl-2-like proteins of VACV are involved in escaping the host
Externí odkaz:
https://doaj.org/article/e39d1e875dcf4cadb8064dd29db4dc45
Autor:
Yongxu Lu, Yiqi Zhao, Chen Gao, Shreehari Suresh, Jinghao Men, Amelia Sawyers, Geoffrey L. Smith
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113788- (2024)
Summary: Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1. Here, we rep
Externí odkaz:
https://doaj.org/article/90572f70155345b6945be5b48bb7cc82
Autor:
Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108080- (2023)
Summary: The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has
Externí odkaz:
https://doaj.org/article/0eb2381740c24412b7c9b4e912187e2a
Autor:
Zixi Yin, Ji-Li Chen, Yongxu Lu, Beibei Wang, Leila Godfrey, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Dannielle Wellington, Yiqi Zhao, Peter A.C. Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Philip Hublitz, Ryan Beveridge, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Timothy Rostron, Juthathip Mongkolsapaya, Gavin R. Screaton, Graham Ogg, Katie Ewer, Andrew J. Pollard, Sarah Gilbert, Julian C. Knight, Teresa Lambe, Geoffrey L. Smith, Tao Dong, Yanchun Peng
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112470- (2023)
Summary: Most existing studies characterizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses are peptide based. This does not allow evaluation of whether tested peptides are processed and presented canonically.
Externí odkaz:
https://doaj.org/article/3206b4dffaab4738b6d887ce4a473de9
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9cffdd23c2be42419963a7e186181590
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune response in the host. For instance, the production of type I interferon (IFN)
Externí odkaz:
https://doaj.org/article/b894fb26c2aa4798a2d961dc81480096
Publikováno v:
Viruses, Vol 14, Iss 2, p 316 (2022)
The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Viral RNA can be detected by RLR rece
Externí odkaz:
https://doaj.org/article/6fdf15c1903c4a93955b71bc04dc98bb
Autor:
Lior Soday, Yongxu Lu, Jonas D. Albarnaz, Colin T.R. Davies, Robin Antrobus, Geoffrey L. Smith, Michael P. Weekes
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1920-1933.e7 (2019)
Summary: Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear factor κB (NF-κB), and type I interferon (IFN) signaling. Here, we use highly mult
Externí odkaz:
https://doaj.org/article/0e7eda6f596646a0bee79bd65314cda5
Publikováno v:
Viruses, Vol 13, Iss 4, p 560 (2021)
Coronaviruses are a large family of zoonotic RNA viruses, whose infection can lead to mild or lethal respiratory tract disease. Severe Acute Respiratory Syndrome-Coronavirus-1 (SARS-CoV-1) first emerged in Guangdong, China in 2002 and spread to 29 co
Externí odkaz:
https://doaj.org/article/6b38d50a5c9d41dba1c0f38908186de6
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1005955 (2016)
The type I interferon (IFN) response is a crucial innate immune signalling pathway required for defense against viral infection. Accordingly, the great majority of mammalian viruses possess means to inhibit this important host immune response. Here w
Externí odkaz:
https://doaj.org/article/14e0e834f7734b31bf827723548285fa