Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

Autor: John Scott, Sonal Thakar, Ye Mao, Huaping Qin, Helen Hejran, Su-Yee Lee, Ting Yu, Olga Klezovitch, Hongqiang Cheng, Yongxin Mu, Sourav Ghosh, Valeri Vasioukhin, Yimin Zou

Publikováno v: iScience, Vol 20, Iss , Pp 25-41 (2019)

Summary: Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the aty

Externí odkaz: https://doaj.org/article/4db09dab8cfd40ea8a63fac71f1df9eb

Cypher and Enigma Homolog Protein Are Essential for Cardiac Development and Embryonic Survival

Autor: Yongxin Mu, Ran Jing, Angela K. Peter, Stephan Lange, Lizhu Lin, Jianlin Zhang, Kunfu Ouyang, Xi Fang, Jennifer Veevers, Xinmin Zhou, Sylvia M. Evans, Hongqiang Cheng, Ju Chen

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 5, Pp n/a-n/a (2015)

Background The striated muscle Z‐line, a multiprotein complex at the boundary between sarcomeres, plays an integral role in maintaining striated muscle structure and function. Multiple Z‐line‐associated proteins have been identified and shown t

Externí odkaz: https://doaj.org/article/0e7a2cd50c6b4e12bb31552ec8fce900

A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice

Autor: Bo Sun, Mingke Ni, Shanshan Tian, Wenting Guo, Shitian Cai, Mads T. Sondergaard, Yongxiang Chen, Yongxin Mu, John P. Estillore, Ruiwu Wang, Ju Chen, Michael T. Overgaard, Michael Fill, Josefina Ramos‐Franco, Mette Nyegaard, Sui Rong Wayne Chen

Publikováno v: Sun, B, Ni, M, Tian, S, Guo, W, Cai, S, Sondergaard, M T, Chen, Y, Mu, Y, Estillore, J P, Wang, R, Chen, J, Overgaard, M T, Fill, M, Ramos-Franco, J, Nyegaard, M & Wayne Chen, S R 2022, ' A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice ', Journal of Cellular Physiology, vol. 237, no. 8, pp. 3305-3316 . https://doi.org/10.1002/jcp.30783
Sun, B, Ni, M, Tian, S, Guo, W, Cai, S, Sondergaard, M T, Chen, Y, Mu, Y, Estillore, J P, Wang, R, Chen, J, Overgaard, M T, Fill, M, Ramos-Franco, J, Nyegaard, M & Wayne Chen, S R 2022, ' A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice ', Journal of cellular physiology, vol. 237, no. 8, pp. 3305-3316 . https://doi.org/10.1002/jcp.30783

Inositol 1,4,5-trisphosphate receptor 1 (ITPR1) is an intracellular Ca2+ release channel critical for numerous cellular processes. Despite its ubiquitous physiological significance, ITPR1 mutations have thus far been linked to primarily movement diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb7193884eed23c179e780e657a9347
https://pubmed.ncbi.nlm.nih.gov/35621185

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

Autor: Olga Klezovitch, Hongqiang Cheng, Ting Yu, Huaping Qin, Sourav Ghosh, Ye Mao, Sonal Thakar, Yongxin Mu, Valeri Vasioukhin, Su-Yee Lee, Yimin Zou, Helen Hejran, John W. Scott

Publikováno v: iScience
iScience, Vol 20, Iss, Pp 25-41 (2019)

Summary Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18ba31a7c96e3054f0dda0fe0cfcfff
https://doi.org/10.1016/j.isci.2019.09.005

O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1

Autor: Ju Chen, Yongxin Mu, Houzhi Yu, Tongbin Wu, Jianlin Zhang, Sylvia M. Evans

Publikováno v: PLoS Genetics, Vol 16, Iss 4, p e1008730 (2020)
PLoS Genetics
PLoS genetics, vol 16, iss 4

O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only enzyme catalyzing O-GlcNAcylation. Although it has been shown that OGT plays an essential role in maintaining postnatal heart function, its role in heart development remains unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec10cb6c14cf78ed57f4318cbf99eb69
https://doaj.org/article/d6d9c9f401734777af729cf91bdea453