Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Yongxin Han"'
Autor:
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Cristina St. Pierre, Pranal J Dakle, Vincenzo Pucci, James Baker, Andrey Loboda, Doug Linn, Christopher Brynczka, Doug Wilson, Brian B Haines, Brian Long, Richard Wnek, Svetlana Sadekova, Michael Rosenzweig, Andrew Haidle, Yongxin Han, Sheila H. Ranganath
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP recep
Externí odkaz:
https://doaj.org/article/36e7a55740434d6e88a502ce5e86b72a
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172938 (2017)
The alternating projection algorithms are easy to implement and effective for large-scale complex optimization problems, such as constrained reconstruction of X-ray computed tomography (CT). A typical method is to use projection onto convex sets (POC
Externí odkaz:
https://doaj.org/article/6175a7ad943b44c5b1d713cfefd36ffb
Publikováno v:
Zhonghua yi xue za zhi. 103(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08542e86503a91e70bcbf09ed9e0626b
https://pubmed.ncbi.nlm.nih.gov/36597740
https://pubmed.ncbi.nlm.nih.gov/36597740
Autor:
Jianyan Wen, Qiangqiang Nie, Yanan Zhen, Yang Chen, Lin Pan, Jie Kong, Chaozeng Si, Mingsheng Sun, Peng Liu, Yongxin Han, Xiaopeng Liu, Feng Wang, Cheng Wang, Zhidong Ye
Publikováno v:
Journal of Cellular Physiology. 237:789-803
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by proliferative vascular remodeling. Abnormal vascular smooth muscle cell (VSMC) phenotype switching is crucial to this process, highlighting the need for VSMC metabolic changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d692c9c43bf40e832202fab88b6035f1
https://doi.org/10.1002/jcp.30543
https://doi.org/10.1002/jcp.30543
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336
Publikováno v:
European Journal of Organic Chemistry. 2020:4581-4605
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607d2b22f0ab574bca83441feca1e491
https://doi.org/10.1002/ejoc.202000679
https://doi.org/10.1002/ejoc.202000679
Autor:
Aili Li, Yongxin Han, Xia Zheng, Peng Liu, Yanan Zhen, Jianbin Zhang, Fan Lin, Xiaopeng Liu, Zhenguo Zhai, Guang Sun
Publikováno v:
Journal of Thoracic Disease. 12:758-764
BACKGROUND: For patients with chronic thromboembolic pulmonary hypertension (CTEPH) and tricuspid regurgitation (TR) undergoing pulmonary thromboendarterectomy (PTE), whether concomitant tricuspid annuloplasty should be carried out is still controver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073286cb3ea88d5d8f09687a416cdbe1
https://doi.org/10.21037/jtd.2019.12.99
https://doi.org/10.21037/jtd.2019.12.99
Autor:
Peng Liu, Xia Zheng, He Wang, Xiaopeng Liu, Yongxin Han, Feng Wang, Qiangqiang Nie, Yanan Zhen
Mitochondrial oxidative injury induces macrophage inflammatory activation and apoptosis during atherogenesis. Timely clearance of dysfunctional mitochondria may therefore be beneficial for the survival of macrophages. Based on these principles, our w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3193662d01209e75c4a213bf8f9cfcf
https://doi.org/10.21203/rs.3.rs-684568/v1
https://doi.org/10.21203/rs.3.rs-684568/v1
Autor:
Theodore A. Martinot, Xavier Fradera, Meredeth A. McGowan, Wensheng Yu, Heidi Ferguson, Purakattle J Biju, H. Zhou, Nicolas Solban, Qinglin Pu, Yongxin Han, Xiao Wang, Kun Liu, Ravi Kurukulasuriya, Yu-hong Lam, Abdelghani Achab, Karin M. Otte, Michael J. Ardolino, Amy C. Doty, Charles A. Lesburg, J. Richard Miller, Yongqi Deng, Mangeng Cheng, Hongjun Zhang, Ian Knemeyer, Nunzio Sciammetta, David Jonathan Bennett
Publikováno v:
ACS Med Chem Lett
[Image: see text] Checkpoint inhibitors have demonstrated unprecedented efficacy and are evolving to become standard of care for certain types of cancers. However, low overall response rates often hamper the broad utility and potential of these break
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fa3b8f261ace5c7d56e064b7047fa
https://doi.org/10.1021/acsmedchemlett.9b00344
https://doi.org/10.1021/acsmedchemlett.9b00344
Publikováno v:
Organic Letters. 21:7199-7203
The bicyclo[1.1.1]pentane (BCP) motif has been utilized as bioisosteres in drug candidates to replace phenyl, tert-butyl, and alkynyl fragments in order to improve physicochemical properties. However, bceause of the difficulty of synthesis, most BCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9af2ee3240bef9282a041069b4bd1ad7
https://doi.org/10.1021/acs.orglett.9b02026
https://doi.org/10.1021/acs.orglett.9b02026