Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yongtang Zheng"'
Autor:
Gui Qian, Yihua Zhang, Yinan Liu, Manman Li, Bowen Xin, Wenyi Jiang, Wendong Han, Yu Wang, Xian Tang, Liuyan Li, Lingyan Zhu, Tao Sun, Bo Yan, Yongtang Zheng, Jianqing Xu, Baoxue Ge, Zheng Zhang, Dapeng Yan
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112442- (2023)
Summary: Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator of interferon genes (STING)-TBK1-IRF3-type I interferon (IFN-I) signalingcas
Externí odkaz:
https://doaj.org/article/6730873d437a4b00a6bc176de79674de
Autor:
Peng Wang, Ronghua Luo, Min Zhang, Yaqing Wang, Tianzhang Song, Tingting Tao, Zhongyu Li, Lin Jin, Hongyi Zheng, Wenwen Chen, Mengqian Zhao, Yongtang Zheng, Jianhua Qin
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)
Abstract COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic, which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and causes severe lung infection and damage. To better understand the molecular ba
Externí odkaz:
https://doaj.org/article/b032d7761a61400ba0d4323d6a198dc5
Autor:
Yumeng Wu, Chengrun Tang, Ruomei Rui, Liumeng Yang, Wei Ding, Jiangyuan Wang, Yiming Li, Christopher C. Lai, Yueping Wang, Ronghua Luo, Weilie Xiao, Hongbing Zhang, Yongtang Zheng, Yanping He
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 512-528 (2020)
A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strai
Externí odkaz:
https://doaj.org/article/7d525690913f449f9b92e02272fa7654
Autor:
Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100448- (2021)
Summary: Activation of nucleic acid sensing Toll-like receptors (TLRs) in B cells is involved in antiviral responses by promoting B cell activation and germinal center responses. In order to take advantage of this natural pathway for vaccine developm
Externí odkaz:
https://doaj.org/article/6677d99468274bcea69009e391b42d59
Autor:
Dongwei Kang, Jinxuan Yang, Lingjin Kong, Ronghua Luo, Xusheng Huang, Tao Zhang, Mengdi Ma, Da Feng, Zhao Wang, Hao Fang, Peng Zhan, Yongtang Zheng, Xinyong Liu
Publikováno v:
Viruses, Vol 14, Iss 11, p 2390 (2022)
HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) area key component of the current HIV-1 combination drug regimens. Although they exhibit potent anti-HIV-1 activity and modest toxicity, the emergence of mutant strains limits their appli
Externí odkaz:
https://doaj.org/article/dc0fa49e01464b4b9461baa2e8dc1293
Autor:
Min Zhang, Peng Wang, Ronghua Luo, Yaqing Wang, Zhongyu Li, Yaqiong Guo, Yulin Yao, Minghua Li, Tingting Tao, Wenwen Chen, Jianbao Han, Haitao Liu, Kangli Cui, Xu Zhang, Yongtang Zheng, Jianhua Qin
Publikováno v:
Advanced Science, Vol 8, Iss 3, Pp n/a-n/a (2021)
Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The models that can accurately resemble human‐relevant responses to viral infection are lacking. Here, a
Externí odkaz:
https://doaj.org/article/2ce0f3c02a2d4d0cb0529de81023bd05
Autor:
Yan Qin, Yuye Li, Wan Liu, Renrong Tian, Qianqian Guo, Shaoyou Li, Hongbin Li, Daojun Zhang, Yongtang Zheng, Li Wu, Ke Lan, Jianhua Wang
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27609 (2011)
Penicillium marneffei (P. marneffei) is considered an indicator pathogen of AIDS, and the endemicity and clinical features of P. marneffei have been described. While, how the co-infection of P. marneffei exacerbate deterioration of the immune respons
Externí odkaz:
https://doaj.org/article/3ac6155590034dd2bb7be57c0f7713cc
Publikováno v:
Chinese Science Bulletin. 67:3654-3666
Publikováno v:
Acta Pharmaceutica Sinica B.
[Dynamic changes and effects of IL-10 secretion B cells during the progression of HIV-1/SIV disease]
Publikováno v:
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 38(5)
Objective To investigate the dynamic changes of IL-10 secretion B cells (B10 cells) in SIVmac239-infected Rhesus macaques and the effects of B10 cells in acquired immunodeficiency syndrome progression. Methods Flow cytometry was applied to quantify C