Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yongtai Bai"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
DNA end resection initiating DNA repair by homologous recombination needs to be delicately regulated. This study shows the interplay between SUMOylation and ubiquitylation maintains MRE11 homeostasis on chromatin, thus facilitating genome stability.
Externí odkaz:
https://doaj.org/article/56f4cfff446241919ef9ee6a6d64fc1b
Autor:
Zelin Liu, Changyu Tao, Shiwei Li, Minghao Du, Yongtai Bai, Xueyan Hu, Yu Li, Jian Chen, Ence Yang
Publikováno v:
eLife, Vol 10 (2021)
Circular RNAs (circRNAs) act through multiple mechanisms via their sequence features to fine-tune gene expression networks. Due to overlapping sequences with linear cognates, identifying internal sequences of circRNAs remains a challenge, which hinde
Externí odkaz:
https://doaj.org/article/1776d376ec994565b99eb9f3a3eb3cb1
Publikováno v:
Life Medicine. 2
To date, over 170 different kinds of chemical modifications on RNAs have been identified, some of which are involved in multiple aspects of RNA fate, ranging from RNA processing, nuclear export, translation, and RNA decay. m6A, also known as N6-methy
Publikováno v:
Genome Instability & Disease. 1:318-338
DNA damage can be caused by both endogenous and environmental factors, such as replication errors, reactive oxygen species (ROS) and chemotherapeutic drugs. Accurate and effective repair of DNA damage can preserve the integrity of the genome. However
Autor:
Hanxiao Li, Xingzhi Xu, Siyu Li, Xiaoman Li, Jun Zhan, Jiadong Wang, Patrick Sung, Mei Zhou, Hongquan Zhang, Qinjian Shen, Jianyuan Luo, Shiwei Li, Xiao Albert Zhou, Weibin Wang, Wei-Guo Zhu, Yanfei Huo, Yongtai Bai, Meimei Zhao
Publikováno v:
Molecular cell. 75(6)
MRE11 nuclease forms a trimeric complex (MRN) with RAD50 and NBS1 and plays a central role in preventing genomic instability. When DNA double-strand breaks (DSBs) occur, MRN is quickly recruited to the damage site and initiates DNA end resection; acc
Autor:
Meimei Zhao, Cai-Hong Yun, Mei Zhou, Hongquan Zhang, Xiang Guo, Qinjian Shen, Yongtai Bai, Jiadong Wang, Wei-Guo Zhu
Publikováno v:
Nucleic Acids Research
P53-binding protein 1 (53BP1) plays critical roles in DNA double strand break (DSB) repair by promoting non-homologous end joining (NHEJ), and loss of 53BP1 abolishes PARPi sensitivity in BRCA1-deficient cells by restoring homologous recombination (H