Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Yongshun Chen"'
Autor:
Qian Chen, Minhui Pang, Peng Chen, Zihao Zhou, Jun Lei, Boxiao He, Zaiqiao Sun, Chonil Paek, Baowei Jing, Yankang Wu, Shiqi Liu, Yongshun Chen, Lei Yin
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract CRISPR/Cas12a‐based combinational screening has shown remarkable potential for identifying genetic interactions. Here, we describe an innovative method for combinational genetic screening with rapid construction of a dual‐CRISPR RNA (crR
Externí odkaz:
https://doaj.org/article/ef996bcaf008462485874f22f8c6ad37
Autor:
Jialing Fang, Jun Lei, Boxiao He, Yankang Wu, Peng Chen, Zaiqiao Sun, Ning Wu, Yafei Huang, Pengcheng Wei, Lei Yin, Yongshun Chen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues showed distinct phenotypes and functions compared to circulating memory T cells and were vital for the initiation of robust immune response within tissues.
Externí odkaz:
https://doaj.org/article/36d6b28360534518916084c0cdbae9ae
Autor:
Yu Yang, Juxian Sun, Jianqiang Cai, Minshan Chen, Chaoliu Dai, Tianfu Wen, Jinglin Xia, Mingang Ying, Zhiwei Zhang, Xuewen Zhang, Chihua Fang, Feng Shen, Ping An, Qingxian Cai, Jingyu Cao, Zhen Zeng, Gang Chen, Juan Chen, Ping Chen, Yongshun Chen, Yunfeng Shan, Shuangsuo Dang, Wei-Xing Guo, Jiefeng He, Heping Hu, Bin Huang, Weidong Jia, Kexiang Jiang, Yan Jin, Yongdong Jin, Yun Jin, Gong Li, Yun Liang, Enyu Liu, Hao Liu, Wei Peng, Zhenwei Peng, Zhiyi Peng, Yeben Qian, Wanhua Ren, Jie Shi, Yusheng Song, Min Tao, Jun Tie, Xueying Wan, Bin Wang, Jin Wang, Kai Wang, Kang Wang, Xin Wang, Wenjing Wei, Fei-Xiang Wu, Bangde Xiang, Lin Xie, Jianming Xu, Mao-Lin Yan, Yufu Ye, Jinbo Yue, Xiaoxun Zhang, Yu Zhang, Aibin Zhang, Haitao Zhao, Weifeng Zhao, Xin Zheng, Hongkun Zhou, Huabang Zhou, Jun Zhou, Xinmin Zhou, Shu-Qun Cheng, Qiu Li
Publikováno v:
Liver Cancer, Pp 1-1 (2024)
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. Most HCC patients have the complications of chronic liver disease and need overall consideration and whole-course management, including diagnosis, treatme
Externí odkaz:
https://doaj.org/article/e461e172d2b44ff2a14326f6d37231d6
Autor:
Hongjian Wang, Jin Zhou, Jun Lei, Guosheng Mo, Yankang Wu, Huan Liu, Ziyan Pang, Mingkun Du, Zihao Zhou, Chonil Paek, Zaiqiao Sun, Yongshun Chen, Yan Wang, Peng Chen, Lei Yin
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002619 (2024)
The CRISPR-associated endonuclease Cas12a has become a powerful genome-editing tool in biomedical research due to its ease of use and low off-targeting. However, the size of Cas12a severely limits clinical applications such as adeno-associated virus
Externí odkaz:
https://doaj.org/article/9b7a0123beda47698ad978df6865508f
Autor:
Peng Chen, Jin Zhou, Huan Liu, Erchi Zhou, Boxiao He, Yankang Wu, Hongjian Wang, Zaiqiao Sun, Chonil Paek, Jun Lei, Yongshun Chen, Xinghua Zhang, Lei Yin
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002514 (2024)
The clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a system is a powerful tool in gene editing; however, crRNA-DNA mismatches might induce unwanted cleavage events, especially at the distal end of the PAM. To minimize this lim
Externí odkaz:
https://doaj.org/article/2bf810d189d143e69343ed2a6da8b008
Autor:
Wensi Zhao, Jun Lei, Shaobo Ke, Yuan Chen, Jiping Xiao, Ze Tang, Li Wang, Yiping Ren, Mohammed Alnaggar, Hu Qiu, Wei Shi, Lei Yin, Yongshun Chen
Publikováno v:
EClinicalMedicine, Vol 66, Iss , Pp 102315- (2023)
Summary: Background: Immunotherapy has revolutionized the treatment of cancer. However, microsatellite stable (MSS) metastatic colorectal cancer (mCRC) shows a low response to PD-1 inhibitors. Antiangiogenic therapy can enhance anti-PD-1 efficacy, bu
Externí odkaz:
https://doaj.org/article/82637cef24b148a3a2c88f91ff67caf0
Autor:
Jing Wang, Shaobo Ke, Yi Gong, Yuxin Cai, Lingling Xia, Zhenguo Shi, Hu Qiu, Wei Shi, Qiushuang Wang, Yongshun Chen
Publikováno v:
Biomedical Journal, Vol 46, Iss 1, Pp 110-121 (2023)
Background: Colorectal cancer (CRC) is a malignant tumor. Recent studies have showed circular RNA (circRNA) participates in the development of CRC. The study was designed to reveal the role of circ_0011385 in CRC progression and underneath mechanism.
Externí odkaz:
https://doaj.org/article/48e0205b432b4e7597e934a0c9d29bb6
Autor:
Hu Qiu, Shaobo Ke, Gaoke Cai, Yong Wu, Jin Wang, Wei Shi, Jiamei Chen, Jin Peng, Baoping Yu, Yongshun Chen
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 213-222 (2023)
Abstract Purpose To evaluate the clinical efficacy and safety of apatinib combined with intensity‐modulated radiation therapy (IMRT) in patients with unresectable hepatocellular carcinoma (uHCC). Materials and methods Open‐label, single‐arm, ex
Externí odkaz:
https://doaj.org/article/e160f46dd6cc4a8cbd6159ee33073ba4
Publikováno v:
地球与行星物理论评, Vol 53, Iss 2, Pp 138-147 (2022)
The occurrence of large earthquakes is not only related to the fault geometry and state of stress accumulation, but also closely related to the structure of surrounding rocks. With the continuous enrichment of observation methods and development of t
Externí odkaz:
https://doaj.org/article/465abf94d6dc4a588ab98dabf17e3f1e
Autor:
Dan San, Jun Lei, Yang Liu, Baowei Jing, Xiang Ye, Pengcheng Wei, Chonil Paek, Yi Yang, Jin Zhou, Peng Chen, Hongjian Wang, Yongshun Chen, Lei Yin
Publikováno v:
Cell Insight, Vol 2, Iss 1, Pp 100076- (2023)
Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the cross-reactivity with different antigen mutants, ca
Externí odkaz:
https://doaj.org/article/33554a7576dd4af7bcea38d550eb4dfc