Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Yongseok Choi"'
Autor:
Tae-Hee Han, Joohan Lee, Dipesh S. Harmalkar, Hyeseul Kang, Guanghai Jin, Min Kyung Park, Minkyoung Kim, Hyun-A Yang, Jinsu Kim, Su Jeong Kwon, Tae-Su Han, Yongseok Choi, Misun Won, Hyun Seung Ban, Kyeong Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116838- (2024)
Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor associated with cancer metabolism and is regarded as a potent anticancer therapeutic strategy within the hypoxic microenvironment of cancer. In this study, stilbenoid derivatives we
Externí odkaz:
https://doaj.org/article/d595514a20df4e729c00fddcaaa926bb
Autor:
Hossam Nada, Anam Rana Gul, Ahmed Elkamhawy, Sungdo Kim, Minkyoung Kim, Yongseok Choi, Tae Jung Park, Kyeong Lee
Publikováno v:
ACS Omega, Vol 8, Iss 35, Pp 31784-31800 (2023)
Externí odkaz:
https://doaj.org/article/e3a4e0934ac24d6cadc6a2241bfd4092
Autor:
Tae Hyun Son, Shin-Hye Kim, Hye-Lim Shin, Dongsoo Kim, Hwan Gyu Kim, Yongseok Choi, Sik-Won Choi
Publikováno v:
Molecules, Vol 29, Iss 10, p 2218 (2024)
Tumor cells in hypoxic conditions control cancer metabolism and angiogenesis by expressing HIF-1α. Tanshinone is a traditional Chinese medicine that has been shown to possess antitumor properties and exerts a therapeutic impact on angiogenesis. Howe
Externí odkaz:
https://doaj.org/article/d422f9ec61014d00865e1583e8946b73
Autor:
Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee, Sunghoon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Direct targeting of oncogenic KRAS activity is a challenge. Here the authors report that a splice variant of AIMP2, AIMP2-DX2, enhances KRAS stability by blocking ubiquitin-mediated degradation of KRAS via the E3 ligase, Smurf2, and identify a chemic
Externí odkaz:
https://doaj.org/article/f7b60731b1ef420298a16914d07b8a55
Autor:
Kwanshik Lee, Hossam Nada, Minkyoung Kim, Hyejun Park, Kiho Lee, Dongho Seo, Kyeong Lee, Yongseok Choi
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1272 (2023)
The diamondback moth is a detrimental insect pest of brassicaceous crops which was among the first crop insects to be reported as DDT resistant. It has since proven to be significantly resistant to nearly every synthetic insecticide used in the field
Externí odkaz:
https://doaj.org/article/50b40af485d44fd89ede4f494eaf2a9a
Publikováno v:
Kidney Research and Clinical Practice, Vol 41, Iss Suppl 2, Pp S89-S98 (2022)
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated c
Externí odkaz:
https://doaj.org/article/bf22b146cb1d4f818ac05e7ce90e5f9f
Autor:
Sreenivasulu Godesi, Hossam Nada, Joohan Lee, Joon-Hee Kang, Soo-Youl Kim, Yongseok Choi, Kyeong Lee
Publikováno v:
Molecules, Vol 28, Iss 13, p 4952 (2023)
Annually, millions of new cancer cases are reported, leading to millions of deaths worldwide. Among the newly reported cases, breast and colon cancers prevail as the most frequently detected variations. To effectively counteract this rapid increase,
Externí odkaz:
https://doaj.org/article/89e2dd38bdae41cfa6c7cc6eeb995e4f
Autor:
Sreenivasulu Godesi, Joohan Lee, Hossam Nada, Guofeng Quan, Ahmed Elkamhawy, Yongseok Choi, Kyeong Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9450 (2023)
The proto-oncogenic protein, c-KIT, plays a crucial role in regulating cellular transformation and differentiation processes, such as proliferation, survival, adhesion, and chemotaxis. The overexpression of, and mutations, in c-KIT can lead to its dy
Externí odkaz:
https://doaj.org/article/1cf1e53732c047d0924763ff74593625
Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment
Autor:
Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won, Kyeong Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 683 (2023)
MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested c
Externí odkaz:
https://doaj.org/article/8a1985dd73694d9e97e63647fd7dfd2c
Publikováno v:
Nuclear Engineering and Technology, Vol 52, Iss 10, Pp 2204-2220 (2020)
An open-pool type research reactor is designed and operated considering the accessibility around the pool top area to enhance the reactor utilization. The reactor structure assembly is placed at the bottom of the pool and filled with water as a prima
Externí odkaz:
https://doaj.org/article/4181e113c22040d487512000476bd7ee