Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Yongseok CHOI"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-32 (2024)
Abstract Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction which marks them as attractive therapeutic drug development targets. What were once considered to be undruggable targets have become increasingly feas
Externí odkaz:
https://doaj.org/article/03adedf9d5f648e4af29614224d87143
Autor:
Hossam Nada, Anam Rana Gul, Ahmed Elkamhawy, Sungdo Kim, Minkyoung Kim, Yongseok Choi, Tae Jung Park, Kyeong Lee
Publikováno v:
ACS Omega, Vol 8, Iss 35, Pp 31784-31800 (2023)
Externí odkaz:
https://doaj.org/article/e3a4e0934ac24d6cadc6a2241bfd4092
Autor:
Tae Hyun Son, Shin-Hye Kim, Hye-Lim Shin, Dongsoo Kim, Hwan Gyu Kim, Yongseok Choi, Sik-Won Choi
Publikováno v:
Molecules, Vol 29, Iss 10, p 2218 (2024)
Tumor cells in hypoxic conditions control cancer metabolism and angiogenesis by expressing HIF-1α. Tanshinone is a traditional Chinese medicine that has been shown to possess antitumor properties and exerts a therapeutic impact on angiogenesis. Howe
Externí odkaz:
https://doaj.org/article/d422f9ec61014d00865e1583e8946b73
Autor:
Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee, Sunghoon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Direct targeting of oncogenic KRAS activity is a challenge. Here the authors report that a splice variant of AIMP2, AIMP2-DX2, enhances KRAS stability by blocking ubiquitin-mediated degradation of KRAS via the E3 ligase, Smurf2, and identify a chemic
Externí odkaz:
https://doaj.org/article/f7b60731b1ef420298a16914d07b8a55
Autor:
Kwanshik Lee, Hossam Nada, Minkyoung Kim, Hyejun Park, Kiho Lee, Dongho Seo, Kyeong Lee, Yongseok Choi
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1272 (2023)
The diamondback moth is a detrimental insect pest of brassicaceous crops which was among the first crop insects to be reported as DDT resistant. It has since proven to be significantly resistant to nearly every synthetic insecticide used in the field
Externí odkaz:
https://doaj.org/article/50b40af485d44fd89ede4f494eaf2a9a
Publikováno v:
Kidney Research and Clinical Practice, Vol 41, Iss Suppl 2, Pp S89-S98 (2022)
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated c
Externí odkaz:
https://doaj.org/article/bf22b146cb1d4f818ac05e7ce90e5f9f
Autor:
Sreenivasulu Godesi, Hossam Nada, Joohan Lee, Joon-Hee Kang, Soo-Youl Kim, Yongseok Choi, Kyeong Lee
Publikováno v:
Molecules, Vol 28, Iss 13, p 4952 (2023)
Annually, millions of new cancer cases are reported, leading to millions of deaths worldwide. Among the newly reported cases, breast and colon cancers prevail as the most frequently detected variations. To effectively counteract this rapid increase,
Externí odkaz:
https://doaj.org/article/89e2dd38bdae41cfa6c7cc6eeb995e4f
Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment
Autor:
Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won, Kyeong Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 683 (2023)
MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested c
Externí odkaz:
https://doaj.org/article/8a1985dd73694d9e97e63647fd7dfd2c
Publikováno v:
Nuclear Engineering and Technology, Vol 52, Iss 10, Pp 2204-2220 (2020)
An open-pool type research reactor is designed and operated considering the accessibility around the pool top area to enhance the reactor utilization. The reactor structure assembly is placed at the bottom of the pool and filled with water as a prima
Externí odkaz:
https://doaj.org/article/4181e113c22040d487512000476bd7ee
Publikováno v:
Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 4, Pp 670-677 (2020)
Objective Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal
Externí odkaz:
https://doaj.org/article/2a9bc06634cd46ff884a11ce197cf234