Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Yongping Yue"'
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Autor:
Seong Eun Kwak, Amy Zheng, Edward B Arias, Haiyan Wang, Xiufang Pan, Yongping Yue, Dongsheng Duan, Gregory D Cartee
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0295964 (2024)
Some acute exercise effects are influenced by postexercise (PEX) diet, and these diet-effects are attributed to differential glycogen resynthesis. However, this idea is challenging to test rigorously. Therefore, we devised a novel genetic model to mo
Externí odkaz:
https://doaj.org/article/d1c21ce50c554ab58163f4a93c052b51
Autor:
Emily D. Morales, Yongping Yue, Thais B. Watkins, Jin Han, Xiufang Pan, Aaron M. Gibson, Bryan Hu, Omar Brito‐Estrada, Gang Yao, Catherine A. Makarewich, Gopal J. Babu, Dongsheng Duan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023)
Background Cardiomyopathy is a leading health threat in Duchenne muscular dystrophy (DMD). Cytosolic calcium upregulation is implicated in DMD cardiomyopathy. Calcium is primarily removed from the cytosol by the sarcoendoplasmic reticulum calcium ATP
Externí odkaz:
https://doaj.org/article/9a37d2fd69cd4921bac7c1d3539ed8f5
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Chady H. Hakim, Nathalie Clément, Lakmini P. Wasala, Hsiao T. Yang, Yongping Yue, Keqing Zhang, Kasun Kodippili, Laura Adamson-Small, Xiufang Pan, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Barry J. Byrne, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 664-678 (2020)
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Externí odkaz:
https://doaj.org/article/c9a8a753dbc949b9af502c5c8edc3335
Autor:
Junling Zhao, Yongping Yue, Aman Patel, Lakmini Wasala, Jacob F. Karp, Keqing Zhang, Dongsheng Duan, Yi Lai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 856-868 (2020)
Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer. Unfortunately, the fate of AAV vectors followi
Externí odkaz:
https://doaj.org/article/4fb0a205845f4a4dad366edfc0540947
Autor:
Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan, Yi Lai
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-15 (2019)
Abstract Background Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystro
Externí odkaz:
https://doaj.org/article/514458d5ae0a4b00b78b428e44390cbd
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Background Loss of sarcolemmal nNOSμ is a common manifestation in a wide variety of muscle diseases and contributes to the dysregulation of multiple muscle activities. Given the critical role sarcolemmal nNOSμ plays in muscle, restoration
Externí odkaz:
https://doaj.org/article/a7389e458dd94fbb8a08a95fc4c329d2
Autor:
Ying Ann Chiao, Huiliang Zhang, Mariya Sweetwyne, Jeremy Whitson, Ying Sonia Ting, Nathan Basisty, Lindsay K Pino, Ellen Quarles, Ngoc-Han Nguyen, Matthew D Campbell, Tong Zhang, Matthew J Gaffrey, Gennifer Merrihew, Lu Wang, Yongping Yue, Dongsheng Duan, Henk L Granzier, Hazel H Szeto, Wei-Jun Qian, David Marcinek, Michael J MacCoss, Peter Rabinovitch
Publikováno v:
eLife, Vol 9 (2020)
Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalize
Externí odkaz:
https://doaj.org/article/720f135c89f7440e948956a2b4dd4a5d
Autor:
Chady H. Hakim, Nalinda B. Wasala, Xiufang Pan, Kasun Kodippili, Yongping Yue, Keqing Zhang, Gang Yao, Brittney Haffner, Sean X. Duan, Julian Ramos, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 216-230 (2017)
Micro-dystrophins are highly promising candidates for treating Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. Here, we report robust disease rescue in the severe DBA/2J-mdx model with a neuronal nitric oxide syn
Externí odkaz:
https://doaj.org/article/a968d82e3a484f8cb6cd48ebc8ad7bec