Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yongnian Sun"'
Autor:
Dahlia R. Weiss, Andrea Bortolato, Yongnian Sun, Xianmei Cai, Chon Lai, Sixuan Guo, Lihong Shi, Veerabahu Shanmugasundaram
Publikováno v:
Journal of Chemical Information and Modeling. 63:2382-2392
Autor:
Xianmei Cai, Shivani Patel, Chunli Huang, Anthony Paiva, Yongnian Sun, Gregory Barker, Harold Weller, Wilson Shou
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 52(7)
Assessment of compound permeability through a Caco-2 cell monolayer is a well-accepted model to evaluate its
Autor:
Emily Luk, Karen E. Parrish, Yue-Zhong Shu, Anwar Murtaza, Yongnian Sun, Jinwen Huang, Robert M. Borzilleri, Paul Stetsko, Mary Ellen Cvijic, Jonathan G. Pabalan, Lihong Cheng, Zheng Yang, Jesse Swanson, James R. Burke, Tatyana Zvyaga, James Smalley, Karen A. Augustine
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:137-149
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has a wide array of biological effects. For decades, tumor biology implicated TGF-β as an attractive therapeutic target due to its immunosuppressive effects. Toward this end, mu
Autor:
Thomas McDonagh, David L. Wensel, Sebastien Tabruyn, Zhufang Li, Tracy S. Mitchell, Jonathan H. Davis, Yongnian Sun, Sharon Zhang, Mark Krystal, Mark I. Cockett, Patrick Nef, David R. Langley
Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17986092965a8eab3c5db82a28136fd
https://europepmc.org/articles/PMC6798092/
https://europepmc.org/articles/PMC6798092/
Autor:
Umesh Hanumegowda, Sharon Zhang, Yan Chen, Zheng Liu, Ira B. Dicker, Zhufang Li, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Terry, Himadri Samanta, Tricia Protack, Brian Lee Venables, Zeyu Lin, Yongnian Sun, Jie Chen, Beata Nowicka-Sans, Alicia Regueiro-Ren, Nicholas A. Meanwell, Matthew D. Healy, Mark Krystal, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy
BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility
Autor:
Bryan Cox, Sangil Lee, Yongnian Sun, Ming B. Huang, Vincent C. Bond, Anthony R. Prosser, Zhufang Li, Lawrence J. Wilson, Mark Krystal, James P. Snyder, Dennis C. Liotta
Publikováno v:
ACS Medicinal Chemistry Letters. 6:753-757
We report novel anti-HIV-1 agents with combined dual host-pathogen pharmacology. Lead compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent mechanisms of action: (1) non-nucleoside reverse transcriptase inhibition, (2) CCR5-me
Autor:
Mark Krystal, Sharon Zhang, Caryn Picarillo, Thomas McDonagh, Jonathan H. Davis, David Fabrizio, Zhufang Li, David L. Wensel, Yongnian Sun, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
A novel fibronectin-based protein (Adnectin) HIV-1 inhibitor was generated using in vitro selection. This inhibitor binds to human CD4 with a high affinity (3.9 nM) and inhibits viral entry at a step after CD4 engagement and preceding membrane fusion
Autor:
Zhufang Li, Yongnian Sun, George J. Hanna, Ira B. Dicker, Max Lataillade, Carol Deminie, Tricia Protack, William Olds, Brian Terry, Mark Krystal, Beata Nowicka-Sans, Carey Hwang, Beatrice Minassian
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5500-5508
BMS-986001 is a novel HIV nucleoside reverse transcriptase inhibitor (NRTI). To date, little is known about its resistance profile. In order to examine the cross-resistance profile of BMS-986001 to NRTI mutations, a replicating virus system was used
Autor:
Wensel, David1, Yongnian Sun2, Davis, Jonathan3, Zhufang Li1, Zhang, Sharon1, McDonagh, Thomas3, Langley, David2, Mitchell, Tracy3, Tabruyn, Sebastien4, Nef, Patrick4, Cockett, Mark1, Krystal, Mark1 Mark.R.Krystal@viivhealthcare.com
Publikováno v:
Journal of Virology. Oct2019, Vol. 93 Issue 20, p1-21. 21p.
Autor:
Xiangzhu Wang, Wengang Yang, Mingjun Huang, Milind Deshpande, Xiaohong Hou, Dawei Chen, Atul Agarwal, Joanne Fabrycki, Yongnian Sun, Avinash Phadke, Yongsen Zhao
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3168-3177
Treatment of hepatitis C patients with direct-acting antiviral drugs involves the combination of multiple small-molecule inhibitors of distinctive mechanisms of action. ACH-806 (or GS-9132) is a novel, small-molecule inhibitor specific for hepatitis