Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yongneng Zhang"'
Autor:
Yongneng Zhang, Sotirios D. Zervopoulos, Aristeidis E. Boukouris, Maria Areli Lorenzana‐Carrillo, Bruno Saleme, Linda Webster, Yongsheng Liu, Alois Haromy, Seyed Amirhossein Tabatabaei Dakhili, John R. Ussher, Gopinath Sutendra, Evangelos D. Michelakis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Isolated loss‐of‐function single nucleotide polymorphisms (SNPs) for SIRT3 (a mitochondrial deacetylase) and UCP2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been associated with both pulmonary arterial h
Externí odkaz:
https://doaj.org/article/a49e84a6a5684a6698b83b6a9fe8c44a
Autor:
Keshav Gopal, Rami Al Batran, Tariq R. Altamimi, Amanda A. Greenwell, Christina T. Saed, Seyed Amirhossein Tabatabaei Dakhili, M. Toni E. Dimaano, Yongneng Zhang, Farah Eaton, Gopinath Sutendra, John R. Ussher
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108935- (2021)
Summary: Type 2 diabetes (T2D) increases the risk for diabetic cardiomyopathy and is characterized by diastolic dysfunction. Myocardial forkhead box O1 (FoxO1) activity is enhanced in T2D and upregulates pyruvate dehydrogenase (PDH) kinase 4 expressi
Externí odkaz:
https://doaj.org/article/c68c21dfb4204bab9f1c90e933d24e88
Autor:
Bruno Saleme, Subhash K. Das, Yongneng Zhang, Aristeidis E. Boukouris, Maria Areli Lorenzana Carrillo, Juan Jovel, Cory S. Wagg, Gary D. Lopaschuk, Evangelos D. Michelakis, Gopinath Sutendra
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 15 (2020)
Externí odkaz:
https://doaj.org/article/153e42a985614650be733b9ed7f11e1b
Autor:
Chaohuan Luo, Xueke Lian, Liangli Hong, Jingfang Zou, Zhi Li, Yuzhang Zhu, Tianliang Huang, Yongneng Zhang, Yaqiu Hu, Huier Yuan, Tengfei Wen, Wanling Zhuang, Bozhi Cai, Xin Zhang, Ichiro Hisatome, Tetsuya Yamamoto, Jiexiong Huang, Jidong Cheng
Publikováno v:
Cellular Physiology and Biochemistry, Vol 40, Iss 3-4, Pp 538-548 (2016)
Background/Aims: Hyperuricemia is part of the metabolic-syndrome cluster of abdominal obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension. Monocytes/macrophages are critical in the development of metabolic syndrome
Externí odkaz:
https://doaj.org/article/991ab3fb6da24df290d97d34ee877241
Autor:
Jidong Cheng, Tianliang Huang, Youfeng Li, Yubai Guo, Yuzhang Zhu, Qingjia Wang, Xiaojun Tan, Weisheng Chen, Yongneng Zhang, Weijie Cheng, Tetsuya Yamamoto, Xubin Jing, Jiexiong Huang
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93256 (2014)
AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid and cholesterol metabolism. Therefore, AMPK is a key therapeutic target in diabetes. Recent pilot studies have suggested that d
Externí odkaz:
https://doaj.org/article/db28dc19a46d45a3bf0704d05f74702b
Autor:
Maria Areli Lorenzana-Carrillo, Keshav Gopal, Nikole J. Byrne, Saymon Tejay, Bruno Saleme, Subhash K. Das, Yongneng Zhang, Alois Haromy, Farah Eaton, Michelle Mendiola Pla, Dawn E. Bowles, Jason R. B. Dyck, John R. Ussher, Evangelos D. Michelakis, Gopinath Sutendra
Publikováno v:
Science translational medicine. 14(669)
Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that translocates to the nucleus to regulate transcription factors in different tissues or pathologic states. Although studied extensively in cancer, its biological role in the heart remains unresolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd40f68d314ccbfdad52c934a617c5c
https://pubmed.ncbi.nlm.nih.gov/36322626
https://pubmed.ncbi.nlm.nih.gov/36322626
Autor:
YONGNENG ZHANG, Evangelos Michelakis
Publikováno v:
Science Translational Medicine. 14
Targeting cell fate may be the most promising approach to treat, reverse, and cure pulmonary arterial hypertension (Zhang et al. ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf8d18d73bf21bc91a2ec601b041ef2
https://doi.org/10.1126/scitranslmed.abq1908
https://doi.org/10.1126/scitranslmed.abq1908
Autor:
John R. Ussher, Yongsheng Liu, Sotirios Zervopoulos, Aristeidis E. Boukouris, Seyed Amirhossein Tabatabaei Dakhili, Yongneng Zhang, Gopinath Sutendra, Maria Areli Lorenzana-Carrillo, Alois Haromy, Evangelos D. Michelakis, Linda Webster, Bruno Saleme
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Isolated loss‐of‐function single nucleotide polymorphisms (SNPs) for SIRT3 (a mitochondrial deacetylase) and UCP2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been associated with both pulmonary arterial h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009a9b5111825f561af3ee6828f8cfe5
https://doi.org/10.1161/jaha.120.020451
https://doi.org/10.1161/jaha.120.020451
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1017e50dbf92ca8b1c8c26d0c059eafb
http://europepmc.org/articles/PMC8650784
http://europepmc.org/articles/PMC8650784
Autor:
Aristeidis E. Boukouris, Yongneng Zhang, Bruno Saleme, Adam Kinnaird, Yuan Yuan Zhao, Yongsheng Liu, Sotirios D. Zervopoulos, Subhash K. Das, Rohan D. Mittal, Alois Haromy, Maria Areli Lorenzana-Carrillo, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Gopinath Sutendra, Evangelos D. Michelakis
Publikováno v:
Cell Reports. 38:110511
An epithelial-to-mesenchymal transition (EMT) phenotype with cancer stem cell-like properties is a critical feature of aggressive/metastatic tumors, but the mechanism(s) that promote it and its relation to metabolic stress remain unknown. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b973a37774eafe3ffb8aab03a6ee4e12
https://doi.org/10.1016/j.celrep.2022.110511
https://doi.org/10.1016/j.celrep.2022.110511