Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yongna Xing"'
Autor:
Emmanuel Vazquez-Rivera, Brenda L. Rojas, Jessica C. Parrott, Anna L. Shen, Yongna Xing, Patrick R. Carney, Christopher A. Bradfield
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1-11 (2022)
Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds small-molecules, supports pr
Externí odkaz:
https://doaj.org/article/30663714268b47fd894efbc2d346cd02
Autor:
Yitong Li, Vijaya Kumar Balakrishnan, Michael Rowse, Cheng-Guo Wu, Anastasia Phoebe Bravos, Vikash K Yadav, Ylva Ivarsson, Stefan Strack, Irina V Novikova, Yongna Xing
Publikováno v:
eLife, Vol 11 (2022)
Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core en
Externí odkaz:
https://doaj.org/article/c37f531dac834f918655f6dade4f99cc
Autor:
Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao, Heide L Ford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosph
Externí odkaz:
https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
Autor:
Cheng-Guo Wu, Aiping Zheng, Li Jiang, Michael Rowse, Vitali Stanevich, Hui Chen, Yitong Li, Kenneth A. Satyshur, Benjamin Johnson, Ting-Jia Gu, Zuojia Liu, Yongna Xing
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Protein phosphatase 2A (PP2A) forms different holoenzymes but little is known about the disassembly of these important signalling complexes. Here the authors present the crystal structure of PP2A bound to TOR signaling pathway regulator (TIPRL) and g
Externí odkaz:
https://doaj.org/article/94a35d46f87a45ba809c7ceade92ca57
Autor:
Feng Guo, Liling Wan, Aiping Zheng, Vitali Stanevich, Yong Wei, Kenneth A. Satyshur, Minhong Shen, Woojong Lee, Yibin Kang, Yongna Xing
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1704-1713 (2014)
Metadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) are overexpressed and interact in diverse cancer types. The structural mechanism of their interaction remains unclear. Here, we determined the high-resolution crystal structure
Externí odkaz:
https://doaj.org/article/5be36acce8ba4c57b1597e879bd0d2d7
Autor:
Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L. Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao, Heide L. Ford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the original version of this Article, the title of the legend to Fig. 7 incorrectly read ‘Knockdown of B55α increases breast cancer metastasis’ instead of ‘Knockdown of B55α decreases breast cancer metastasis’. This has now been correcte
Externí odkaz:
https://doaj.org/article/01f8112d1c1445b7aa67d2d545f6604b
Autor:
Kumar Kotlo, Yongna Xing, Sonia Lather, Jean Michel Grillon, Keven Johnson, Randal A Skidgel, R John Solaro, Robert S Danziger
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85000 (2014)
Serine-threonine Protein phosphatase 2 A (PP2A), a member of the PPP family of phosphatases, regulates a variety of essential cellular processes, including cell-cycling, DNA replication, transcription, translation, and secondary signaling pathways. I
Externí odkaz:
https://doaj.org/article/6d237a7cceaa4b12bb99510f9ee5bce7
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86955 (2014)
The function of the biologically essential protein phosphatase 2A (PP2A) relies on formation of diverse heterotrimeric holoenzymes, which involves stable association between PP2A scaffold (A) and catalytic (C or PP2Ac) subunits and binding of variabl
Externí odkaz:
https://doaj.org/article/de3e243739084c04bc089586f7aa6700
Autor:
Joshua D Mezrich, Linh P Nguyen, Greg Kennedy, Manabu Nukaya, John H Fechner, Xiaoji Zhang, Yongna Xing, Christopher A Bradfield
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44547 (2012)
The experimental compound SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor, but showed poor results. Here, we show that SU5416 is also an aryl hydrocarbon receptor (AHR)
Externí odkaz:
https://doaj.org/article/c548902f764d48a698095ffb510ae371
Autor:
Sarah J Dickerson, Yongna Xing, Amanda R Robinson, William T Seaman, Henri Gruffat, Shannon C Kenney
Publikováno v:
PLoS Pathogens, Vol 5, Iss 3, p e1000356 (2009)
The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like motifs (ZREs), induces expression of the BRLF1 (R) and BRRF1 (Na)
Externí odkaz:
https://doaj.org/article/8f261fa6325e48f2a2f688a2e99484ae