Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Yongli Gu"'
Laser accelerators can provide proton beams with unique qualities, such as micron size, picosecond pulse duration and high peak current, and have been demonstrated for various applications and for scientific research purposes. The effect of the space
Externí odkaz:
http://arxiv.org/abs/2209.01743
Autor:
Sarah Bond, Saeho Chong, Tuyen Nguyen, Justin Darcy, Saket Agarwal, Maja M. Janas, Jing-Tao Wu, Samantha Chigas, Yongli Gu, Ruth Allard
Publikováno v:
Nucleic Acid Therapeutics
Serum protein interactions are evaluated during the drug development process since they determine the free drug concentration in blood and thereby can influence the drug's pharmacokinetic and pharmacodynamic properties. While the impact of serum prot
Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Publikováno v:
Chinese Science Bulletin.
Autor:
Zhanyong Zhao, Yongli Guo, Wenbo Du, Peikang Bai, Zhen Zhang, Liqing Wang, Kai Ma, Sheng Zhang, Xiuzhu Han, Chen Yang
Publikováno v:
Journal of Materials Research and Technology, Vol 31, Iss , Pp 534-542 (2024)
In this paper, Ti6Al4V alloy and Ti6Al4V-SiCw composites were formed by selective laser melting (SLM) and electrochemical corrosion experiments were carried out. The effects of different SiCw contents and solid solution aging heat treatment on the co
Externí odkaz:
https://doaj.org/article/fb2ce1fcab524cc5918a2a9052de27ff
Autor:
Shannon Gutierrez, Yuanxin Xu, Gabriel J. Robbie, Carrie Rocca, Samantha Chigas, James Butler, Saeho Chong, Yongli Gu, Sean Dennin, Joohwan Kim, Kirk Brown, Diana Najarian, Klaus Charisse
Publikováno v:
Bioanalysis. 11:1927-1939
Aim: The electrophoretic mobility shift assay (EMSA) was evaluated as an alternative to ultrafiltration (UF) to assess plasma protein binding (PPB) of small interfering RNAs (siRNA) and antisense oligonucleotides (ASO). Results & methodology: EMSA an
Publikováno v:
Hydrology Research, Vol 55, Iss 3, Pp 380-391 (2024)
The hydrological dynamics and sources of karst tidal springs are difficult to capture and quantify due to fluctuations in their flow velocity. In this study, the Laolongshui (LLS) karst tidal spring in the Maocun underground river basin of Guilin Cit
Externí odkaz:
https://doaj.org/article/5fd70cd624b94cae8c83168743eb5e1e
Autor:
Valerie A. Clausen, Brad Zerler, Jim Jiang, Jing-Tao Wu, Krishna Aluri, Joohwan Kim, Diane Ramsden, Sajida Iqbal, Yongli Gu, Saeho Chong, Sean Dennin
Publikováno v:
Drug Metabolism and Disposition. 47:1183-1194
Small interfering RNAs (siRNAs) represent a new class of medicines that are smaller (∼16,000 Da) than biologic therapeutics (>150,000 Da) but much larger than small molecules ( 3000-fold above the therapeutic clinical Cmax at steady state, and impo
Autor:
Robin, McDougall, Diane, Ramsden, Sagar, Agarwal, Saket, Agarwal, Krishna, Aluri, Michael, Arciprete, Christopher, Brown, Elena, Castellanos-Rizaldos, Klaus, Charisse, Saeho, Chong, Joseph, Cichocki, Kevin, Fitzgerald, Varun, Goel, Yongli, Gu, Dale, Guenther, Bahru, Habtemariam, Vasant, Jadhav, Maja, Janas, Muthusamy, Jayaraman, Jeffrey, Kurz, Jing, Li, Ju, Liu, Xiumin, Liu, Steven, Liou, Chris, Maclauchlin, Martin, Maier, Muthiah, Manoharan, Jayaprakash K, Nair, Gabriel, Robbie, Karyn, Schmidt, Peter, Smith, Christopher, Theile, Akshay, Vaishnaw, Scott, Waldron, Yuanxin, Xu, Xuemei, Zhang, Ivan, Zlatev, Jing-Tao, Wu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(6)
Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or antisense oligonucleotides, to
Autor:
Kunming Zhao, Xinyi Wang, Yaqiong Jin, Xiaoxiao Zhu, Tao Zhou, Yongbo Yu, Xiaoying Ji, Yan Chang, Jiao Luo, Xin Ni, Yongli Guo, Dianke Yu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Neuroblastoma (NB) is a challenging pediatric extracranial solid tumor characterized by a poor prognosis and resistance to chemotherapy. Identifying targets to enhance chemotherapy sensitivity in NB is of utmost importance. Increasing eviden
Externí odkaz:
https://doaj.org/article/4ebccb1a172945179fb616d148c78419