Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Yongjun Sui"'
Autor:
Mohammad Arif Rahman, Massimiliano Bissa, Hanna Scinto, Savannah E. Howe, Sarkis Sarkis, Zhong-Min Ma, Anna Gutowska, Xunqing Jiang, Christina C. Luo, Luca Schifanella, Ramona Moles, Isabela Silva de Castro, Shraddha Basu, Kombo F. N’guessan, LaTonya D. Williams, Manuel Becerra-Flores, Melvin N. Doster, Tanya Hoang, Hyoyoung Choo-Wosoba, Emmanuel Woode, Yongjun Sui, Georgia D. Tomaras, Dominic Paquin-Proulx, Mangala Rao, James D. Talton, Xiang-Peng Kong, Susan Zolla-Pazner, Timothy Cardozo, Genoveffa Franchini, Jay A. Berzofsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17+NKp44+ innate lym
Externí odkaz:
https://doaj.org/article/c46022c8eff943a69e28ba2d4818429f
Autor:
Yongjun Sui, Jay A. Berzofsky
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
While most of the cancer immunotherapy strategies engage adaptive immunity, especially tumor-associated T cells, the small fraction of responding patients and types of cancers amenable, and the possibility of severe adverse effects limit its usage. M
Externí odkaz:
https://doaj.org/article/ebd0dbf2645142c18f640d58248001f1
Autor:
Jianping Li, Kevin S. Hsu, Savannah E. Howe, Tanya Hoang, Zheng Xia, Jay A. Berzofsky, Yongjun Sui
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCurrent vaccines against COVID-19 administered via parenteral route have limited ability to induce mucosal immunity. There is a need for an effective mucosal vaccine to combat SARS-CoV-2 virus replication in the respiratory mucosa. Moreov
Externí odkaz:
https://doaj.org/article/4e479ea0c0954aca9c38c6e747d8ff1b
Autor:
Yongjun Sui, Hanne Andersen, Jianping Li, Tanya Hoang, Yonas Bekele, Swagata Kar, Mark G. Lewis, Jay A. Berzofsky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAdjuvant plays an important role in directing the immune responses induced by vaccines. In previous studies, we have shown that a mucosal SARS-CoV-2 S1 subunit vaccine adjuvanted with a combination of CpG, Poly I:C and IL-15 (named CP15)
Externí odkaz:
https://doaj.org/article/8dd1479024234e54afb4666e3c0b1c9c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis
Externí odkaz:
https://doaj.org/article/c277c1400df34acbbac3af2da587f5de
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
SARS-CoV-2 virus causes upper and lower respiratory diseases including pneumonia, and in some cases, leads to lethal pulmonary failure. Angiotensin converting enzyme-2 (ACE2), the receptor for cellular entry of SARS-CoV-2 virus, has been shown to pro
Externí odkaz:
https://doaj.org/article/8a81eabb5c544eff84df2792112962ec
Autor:
Yongjun Sui, Jianping Li, Roushu Zhang, Sunaina Kiran Prabhu, Hanne Andersen, David Venzon, Anthony Cook, Renita Brown, Elyse Teow, Jason Velasco, Jack Greenhouse, Tammy Putman-Taylor, Tracey-Ann Campbell, Laurent Pessaint, Ian N. Moore, Laurel Lagenaur, Jim Talton, Matthew W. Breed, Josh Kramer, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Mark G. Lewis, Lai-Xi Wang, Jay A. Berzofsky
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have focused on systemic immunization, here we compared the protective efficacy of 2 adjuvanted subunit vaccines with spike protein S1: an intramuscularly primed/boos
Externí odkaz:
https://doaj.org/article/d56cb415c28b4c54afc3a16c9c73cf2f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CXCL13 signals through the G protein-coupled chemokine receptor CXCR5 to drive development of secondary lymphoid tissue as well as B cell and Tfh cell trafficking to germinal centers (GC), which leads to the differentiation of B cells to plasma cells
Externí odkaz:
https://doaj.org/article/76aa299e809e4f47a8e7e7498bee44cf
Autor:
Yongjun Sui, Jay A. Berzofsky
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Trained innate immunity has recently emerged as a novel concept of innate immune cells, such as myeloid cells, exhibiting immune memory, and nonspecific heterologous immunity to protect against infections. The memory and specificity are mediated by e
Externí odkaz:
https://doaj.org/article/71d9c61b5ec8471f863fbfd3c326eb1b
Autor:
Monica Vaccari, Slim Fourati, Dallas R. Brown, Isabela Silva de Castro, Massimiliano Bissa, Luca Schifanella, Melvin N. Doster, Kathryn E. Foulds, Mario Roederer, Richard A. Koup, Yongjun Sui, Jay A. Berzofsky, Rafick-Pierre Sekaly, Genoveffa Franchini
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Vaccination with DNA-SIV + ALVAC-SIV + gp120 alum results in inflammasome activation, high levels of IL-1β production, emergency myelopoiesis, and the egress of CXCR4+ CD14+ pre-monocytes from bone marrow. Previously we have shown that this vaccine-
Externí odkaz:
https://doaj.org/article/b456d75223ed40b68fd3299cd3e0c444