Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yongjin, Gong"'
Autor:
Dean F. Rigel, Gary M. Coppola, Frederic Villard, Li Fan, Muneto Mogi, Emma Cody, Nikolaus Schiering, Guiqing Liang, Christian Wiesmann, Arco Y. Jeng, Yongjin Gong, Jing Liu, Paul Ramage, Fumin Fu, Alan D. Neubert, Yuki Iwaki, Allan D'Arcy, Qian Liu, Wei Chen, Jennifer Leung-Chu, Robert Sun, Rajeshri Ganesh Karki, Frederic Cumin, Toshio Kawanami, Gary Michael Ksander, Sara Ingles, Michael E. Beil
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inhibition of neprilysin (NEP) is widely studied as a therapeutic target for the treatment of hypertension, heart failure, and kidney disease. Sacubitril/valsartan (LCZ696) is a drug approved to reduce the risk of cardiovascular dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2573c39ef5000dc9e148109a83e4e51
https://doi.org/10.1021/acsmedchemlett.9b00578
https://doi.org/10.1021/acsmedchemlett.9b00578
Autor:
Wei-Sheng, Huang, Feng, Li, Yongjin, Gong, Yun, Zhang, Willmen, Youngsaye, Yongjin, Xu, Xiaotian, Zhu, Matthew T, Greenfield, Anna, Kohlmann, Paul M, Taslimi, Angela, Toms, Stephan G, Zech, Tianjun, Zhou, Biplab, Das, Hyun G, Jang, Meera, Tugnait, Yihua E, Ye, Francois, Gonzalvez, Theresa E, Baker, Sara, Nadworny, Yaoyu, Ning, Scott D, Wardwell, Sen, Zhang, Alexandra E, Gould, Yongbo, Hu, Weston, Lane, Robert J, Skene, Hua, Zou, Tim, Clackson, Narayana I, Narasimhan, Victor M, Rivera, David C, Dalgarno, William C, Shakespeare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 80:129084
In the treatment of non-small cell lung cancer (NSCLC), patients harboring exon 20 insertion mutations in the epidermal growth factor receptor (EGFR) gene (EGFR) have few effective therapies because this subset of mutants is generally resistant to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36257c29b5ae4b54e2d345df53177fd7
https://doi.org/10.1016/j.bmcl.2022.129084
https://doi.org/10.1016/j.bmcl.2022.129084
Autor:
Michael H. Serrano-Wu, Alan D. Neubert, Katsumasa Nakajima, Jingzhou Li, Qing Yang, David Truong, Kevin B. Clairmont, Renee Commerford, Aaron Kanter, Thomas Daniels, Young-Shin Kwak, Paul V. Szklennik, Yongjin Gong, Vivienne Tedesco, Gary M. Coppola, Brian K. Hubbard, Ricardo E. Chatelain, Thomas A. Gilmore, Charles D. Meyers, Forster Cornelia J, Monish Jain, James Thompson
Publikováno v:
Journal of medicinal chemistry. 60(11)
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa6137e12579f36a972ee08d1ca7bc6
https://pubmed.ncbi.nlm.nih.gov/28498655
https://pubmed.ncbi.nlm.nih.gov/28498655
Autor:
Taeyoung Yoon, Kevin B. Clairmont, Yongjin Gong, Qing Yang, Marlene Juedes, Andrew Tyler, Michael H. Serrano-Wu, Theresa Cosker, Moo Je Sung, Tara L. Mullarkey, Lisha Li, Gary M. Coppola, Alan D. Neubert, Thomas Daniels, Erik C. Rocheford, Renee Commerford, Ying Hou, Ricardo E. Chatelain, Monish Jain, Brian K. Hubbard
Publikováno v:
ACS Medicinal Chemistry Letters. 3:411-415
High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d7df1bc35c3873046f61a201f435be
https://doi.org/10.1021/ml3000512
https://doi.org/10.1021/ml3000512
Autor:
Gary M. Coppola, Yongjin Gong
Publikováno v:
Organic Preparations and Procedures International. 39:199-202
(2007). A RELIABLE, HIGH-YIELDING PREPARATION OF 2, 6-DIMETHYL-4-HYDROXYBENZALDEHYDE. Organic Preparations and Procedures International: Vol. 39, No. 2, pp. 199-202.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aca851626b615b6b2b72152f76d7975
https://doi.org/10.1080/00304940709356013
https://doi.org/10.1080/00304940709356013
Autor:
Jenny Zhan, Monish Jain, Paul V. Szklennik, Eric Gangl, Leslie Bell, Yongjin Gong, Susanne Glowienke, Aaron Kanter, Shari Bickford, Forster Cornelia J, Gilmore Thomas A, Pascal Stadelmann, Youngshin Kwak, Bryan W. Stroup, Alan D. Neubert, Gary M. Coppola, Mithat Gunduz, Michael H. Serrano-Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
A series of 2-[(2,6)-dimethylphenyl]benzimidazole analogs displayed strong potential for mutagenicity following metabolic activation in either TA98 or TA100 Salmonella typhimurium strains. The number of revertants was significantly reduced by replaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99dc733ec94c202fd37467b2c476523
https://pubmed.ncbi.nlm.nih.gov/21295471
https://pubmed.ncbi.nlm.nih.gov/21295471