Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Yongge Zhao"'
Autor:
Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-depende
Externí odkaz:
https://doaj.org/article/784327815c984356aac217a9fbd2ed1e
Autor:
Christelle Harly, Devin Kenney, Yueqiang Wang, Yi Ding, Yongge Zhao, Parirokh Awasthi, Avinash Bhandoola
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendrit
Externí odkaz:
https://doaj.org/article/20d655e96b02401380accce2ff042d76
Autor:
William D. Coley, Yongge Zhao, Charles J. Benck, Yi Liu, Chie Hotta-Iwamura, M. Jubayer Rahman, Kristin V Tarbell
Publikováno v:
F1000Research, Vol 7 (2018)
Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2+ dendritic cells (DCs) in vivo inhibi
Externí odkaz:
https://doaj.org/article/128c4a67c9604385b16a311bc236b468
Autor:
William D. Coley, Yongge Zhao, Charles J. Benck, Yi Liu, Chie Hotta-Iwamura, M. Jubayer Rahman, Kristin V Tarbell
Publikováno v:
F1000Research, Vol 7 (2018)
Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2+ dendritic cells (DCs) in vivo inhibi
Externí odkaz:
https://doaj.org/article/efdfaebe194741f09618cb787b4f24e1
Publikováno v:
PLoS Biology, Vol 14, Iss 6, p e1002502 (2016)
[This corrects the article DOI: 10.1371/journal.pbio.1000518.].
Externí odkaz:
https://doaj.org/article/c7712a54c4d44be3a285a2ab18609aba
Autor:
Meghan A Jendrysik, Sam Vasilevsky, Liang Yi, Adam Wood, Nannan Zhu, Yongge Zhao, Sherry M Koontz, Sharon H Jackson
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28198 (2011)
NADPH oxidase-2 (Nox2)/gp91(phox) and p47(phox) deficient mice are prone to hyper-inflammatory responses suggesting a paradoxical role for Nox2-derived reactive oxygen species (ROS) as anti-inflammatory mediators. The molecular basis for this mode of
Externí odkaz:
https://doaj.org/article/56b113ae908f42a18abd4761c3af293a
Publikováno v:
PLoS Biology, Vol 8, Iss 10, p e1000518 (2010)
Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of th
Externí odkaz:
https://doaj.org/article/7f30bd7eeb4b4f4f9b8fa0d2fa2b3947
Autor:
Michail S. Lionakis, Jonathan J. Lyons, Diego B. Lopez, Timothy J. Break, Alexandra F. Freeman, Michael P. O'Connell, John S. Barber, Yongge Zhao, Yuan Zhang, Daniel L. Barber, Monica G. Lawrence, Steven M. Holland, Chi Ma, Joshua D. Milner
Publikováno v:
Journal of Experimental Medicine. 214:2523-2533
Patients with hypomorphic mutations in STAT3 and patients with hypermorphic mutations in STAT1 share several clinical and cellular phenotypes suggesting overlapping pathophysiologic mechanisms. We, therefore, examined cytokine signaling and CD4+ T ce
Autor:
Christelle, Harly, Devin, Kenney, Yueqiang, Wang, Yi, Ding, Yongge, Zhao, Parirokh, Awasthi, Avinash, Bhandoola
Publikováno v:
Frontiers in Immunology
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendrit
Autor:
Yongge Zhao, Chie Hotta-Iwamura, M. Jubayer Rahman, Alan D. Guerrero, Matthew B. Dong, Kameron B. Rodrigues, Yi Chen, Kristin V. Tarbell, Gwendoline Rahir
Publikováno v:
The Journal of Immunology. 196:2031-2040
Innate immune signals help break self-tolerance to initiate autoimmune diseases such as type 1 diabetes, but innate contributions to subsequent regulation of disease progression are less clear. Most studies have measured in vitro innate responses of