Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Yongfeng Fan"'
Autor:
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Publikováno v:
Toxins, Vol 15, Iss 5, p 316 (2023)
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable
Externí odkaz:
https://doaj.org/article/276c0b76216c46e0a1b5bb0297a8d1eb
Autor:
Yongfeng Fan, Zhengda Sun, Fraser Conrad, Weihua Wen, Lequn Zhao, Jianlong Lou, Yu Zhou, Shauna Farr-Jones, James D Marks
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273512 (2022)
Generating specific monoclonal antibodies (mAbs) that neutralize multiple antigen variants is challenging. Here, we present a strategy to generate mAbs that bind seven subtypes of botulinum neurotoxin serotype F (BoNT/F) that differ from each other i
Externí odkaz:
https://doaj.org/article/7144f5bc7dae452e9022a675df09d5ef
Autor:
Guanming Huang, Mingmin Liu, Hongliang Yang, Haiyang Zhang, Yongfeng Fan, Feng Xie, Shengli Ge
Publikováno v:
Jixie chuandong, Vol 43, Pp 55-58 (2019)
In order to enhance the performance of fighter， and realize the aim of lightweight design of aircraft gun， taking the transmission gear of a certain aircraft gun ammunition box as the research object， through topological optimization method of
Externí odkaz:
https://doaj.org/article/40c18e89442a4b46a1b089b1ef5f3e88
Publikováno v:
Applied Sciences, Vol 12, Iss 12, p 5976 (2022)
To analyze the multi-dimensional seismic mitigation performance and the torsional vibration characteristic of an L-shaped frame structure with a magnetorheological damper (MRD). Firstly, the mechanical property of the MRD is experimentally studied. T
Externí odkaz:
https://doaj.org/article/a824f320c6df4519aca5212afdee6296
Publikováno v:
Advances in Civil Engineering, Vol 2021 (2021)
The freeze-thaw cycles cause deterioration in mechanical properties of levee soil and further endanger the pavement structure on the embankment. This study attempts to comprehensively understand the mechanical response of pavement after freeze-thaw c
Externí odkaz:
https://doaj.org/article/9798ed116cfa44308328273ae02d698f
Autor:
Yongfeng Fan, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Isin N. Geren, Consuelo Garcia-Rodriguez, Theresa J. Smith, Leonard A. Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A. Wilson, James D. Marks
Publikováno v:
Toxins, Vol 7, Iss 9, Pp 3405-3423 (2015)
Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could in
Externí odkaz:
https://doaj.org/article/6b1b373bea8b45a2adb6651086bec8a0
Autor:
Yongfeng Fan, Consuelo Garcia-Rodriguez, Jianlong Lou, Weihua Wen, Fraser Conrad, Wenwu Zhai, Theresa J Smith, Leonard A Smith, James D Marks
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174187 (2017)
Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with the amino acid sequence difference between subtypes as high
Externí odkaz:
https://doaj.org/article/6184a309773e437897fdc911de7196ba
Autor:
Yongfeng Fan, Isin N Geren, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Theresa J Smith, Leonard A Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A Wilson, James D Marks
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135306 (2015)
The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used
Externí odkaz:
https://doaj.org/article/9b7eb01863404d988154a05871b0cbf5
Autor:
Marie-Alix Poul, André Pèlegrin, James D. Marks, Yu Zhou, Yongfeng Fan, Christian Auclair, Madeline Neiveyans, Ronan Crépin, Marianne Le Gall
Figure S3: Characterization of UT-7/Epo, HMC1.1 and HMC1.2 cell lines. Figure S4: 2D1 and 3G1-Fc do not compete with 104D2 mAb binding to KIT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0966750bdac5108388badbda58b112
https://doi.org/10.1158/1535-7163.22507155
https://doi.org/10.1158/1535-7163.22507155
Autor:
Marie-Alix Poul, André Pèlegrin, James D. Marks, Yu Zhou, Yongfeng Fan, Christian Auclair, Madeline Neiveyans, Ronan Crépin, Marianne Le Gall
Materials and methods describing the production of scFv-Fc in HEK-T cells and KIT domains and scFv display on yeast. Table S2: Primers for PCR amplification of KIT and cloning into pYD vector by Gap repair. Figure S1: Selection and initial characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e198400aa10438db5dd6e92282dd1ac
https://doi.org/10.1158/1535-7163.22507152.v1
https://doi.org/10.1158/1535-7163.22507152.v1