Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Yongcheol Cho"'
Autor:
Da Eun Yoon, Na-Rae Kim, Soo-Ji Park, Tae Yeong Jeong, Bokkee Eun, Yongcheol Cho, Soo-Yeon Lim, Hyunji Lee, Je Kyoung Seong, Kyoungmi Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 12, Pp 2586-2595 (2023)
Abstract Base editors are powerful tools for making precise single-nucleotide changes in the genome. However, they can lead to unintended insertions and deletions at the target sites, which is a significant limitation for clinical applications. In th
Externí odkaz:
https://doaj.org/article/25a4b96c942c4f318dc48649416be12b
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
Autor:
Min Ji Yoon, Boyoon Choi, Eun Jin Kim, Jiyeon Ohk, Chansik Yang, Yeon-Gil Choi, Jinyoung Lee, Chanhee Kang, Hyun Kyu Song, Yoon Ki Kim, Jae-Sung Woo, Yongcheol Cho, Eui-Ju Choi, Hosung Jung, Chungho Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
p62/SQSTM1 acts as a key mediator in the selective autophagy of protein aggregates, or aggrephagy. Here the authors identify the prefoldin-like chaperone UXT as an autophagy adaptor of p62 dependent aggrephagy and show that ectopic UXT expression del
Externí odkaz:
https://doaj.org/article/f97d34af557c40b1a93c7c19606cff1c
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various co
Externí odkaz:
https://doaj.org/article/793dde447c8e4bff8d97daf00259a5dd
Autor:
Youngkyung Cho, Sang Bum Kim, Jiyoon Kim, An Vuong Quynh Pham, Min Ji Yoon, Jeong Hwan Park, Ki-Tae Hwang, Dongeun Park, Yongcheol Cho, Moon Gyo Kim, Chungho Kim
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through its ectodomain sheddi
Externí odkaz:
https://doaj.org/article/065e4f08cac044eb9687e520f47cd284
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 178-192 (2019)
Following damage to a peripheral nerve, injury signaling pathways converge in the cell body to generate transcriptional changes that support axon regeneration. Here, we demonstrate that dual leucine zipper kinase (DLK), a central regulator of injury
Externí odkaz:
https://doaj.org/article/61b1dcf5f9fd4b019c439db7fb381a9e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Calcium ions (Ca2+) play critical roles in neuronal processes, such as signaling pathway activation, transcriptional regulation, and synaptic transmission initiation. Therefore, the regulation of Ca2+ homeostasis is one of the most important processe
Externí odkaz:
https://doaj.org/article/1535f0fa72a1431980b38c122070fae8
βPix-d promotes tubulin acetylation and neurite outgrowth through a PAK/Stathmin1 signaling pathway.
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230814 (2020)
Microtubules are a major cytoskeletal component of neurites, and the regulation of microtubule stability is essential for neurite morphogenesis. βPix (ARHGEF7) is a guanine nucleotide exchange factor for the small GTPases Rac1 and Cdc42, which modul
Externí odkaz:
https://doaj.org/article/49d51f4a96e44dfaa1d96f6989d9d4f1
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233327 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0230814.].
Externí odkaz:
https://doaj.org/article/9887a69f3abf4283a273bf2da6fad759
Autor:
Yongcheol Cho, Jinyoung Lee
Publikováno v:
Experimental & Molecular Medicine
Axon regeneration is orchestrated by many genes that are differentially expressed in response to injury. Through a comparative analysis of gene expression profiling, injury-responsive genes that are potential targets for understanding the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2c33a3155097c1262c56b310c43e11
http://europepmc.org/articles/PMC8080715
http://europepmc.org/articles/PMC8080715
Publikováno v:
Molecular Neurobiology. 58:750-760
Neurons are vulnerable to injury, and failure to activate self-protective systems after injury leads to neuronal death. However, sensory neurons in dorsal root ganglions (DRGs) mostly survive and regenerate their axons. To understand the mechanisms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf33b54bfe9eb706c23da7216eb69b54
https://doi.org/10.1007/s12035-020-02155-2
https://doi.org/10.1007/s12035-020-02155-2