Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yongcheng Pan"'
Autor:
Jiyun Hu, Zetong Xing, Hongbing Yang, Yongli Zhou, Liufei Guo, Xianhong Zhang, Longsheng Xu, Qiong Liu, Jing Ye, Xiaoming Zhong, Jixin Wang, Ruoyao Lin, Erping Long, Jiewei Jiang, Liang Chen, Yongcheng Pan, Lang He, Jia-Yu Chen
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110584- (2024)
Summary: R-loops play diverse functional roles, but controversial genomic localization of R-loops have emerged from experimental approaches, posing significant challenges for R-loop research. The development and application of an accurate computation
Externí odkaz:
https://doaj.org/article/c714c0812b68414f9e41a158f9664b95
Autor:
Yongcheng Pan, Ying Jiang, Juan Wan, Zhengmao Hu, Hong Jiang, Lu Shen, Beisha Tang, Yun Tian, Qiong Liu
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranuclear inclusions in the nervous system as well as multiple visceral organs. In 2019, expanded GGC repeats withi
Externí odkaz:
https://doaj.org/article/8767305a81f74d1291f3120b40d47fd2
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT). Ras homolog enriched in the striatum (
Externí odkaz:
https://doaj.org/article/2fc59d55ef1e40448c87c4b1e4a63500
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Vanishing white matter disease (VWM) is one of the most common childhood inherited leukoencephalopathies with autosomal recessive inheritance. Mutations in five genes, EIF2B1-5, have been identified as the major cause of VWM. In this study, a targete
Externí odkaz:
https://doaj.org/article/4462d486707e44be93198e0514ffcb5f
Autor:
Huiming Yang, Su Yang, Liang Jing, Luoxiu Huang, Luxiao Chen, Xianxian Zhao, Weili Yang, Yongcheng Pan, Peng Yin, Zhaohui S Qin, Beisha Tang, Shihua Li, Xiao-Jiang Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The mechanisms by which mutant Huntington protein Htt leads to selective neurodegeneration are not fully understood. Here, using gene editing in HD140Q knock-in mice, the authors show that exon1 Htt is a critical pathological form of the protein.
Externí odkaz:
https://doaj.org/article/f7ec8fe55f5148dab5116e4f227b70c1
Autor:
Qiong Liu, Shanshan Huang, Peng Yin, Su Yang, Jennifer Zhang, Liang Jing, Siying Cheng, Beisha Tang, Xiao-Jiang Li, Yongcheng Pan, Shihua Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
It is not yet clear how ubiquitously-expressed proteins can cause the selective degeneration of particular populations of neurons, such as in spinocerebellar ataxia type 17, SCA17, which results from a CAG trinucleotide repeat expansion in the ubiqui
Externí odkaz:
https://doaj.org/article/2411a8058950408fae8d5c6dceaba888
Autor:
Xingxing Chen, Ning Xin, Yongcheng Pan, Louyin Zhu, Peng Yin, Qiong Liu, Weili Yang, Xingshun Xu, Shihua Li, Xiao-Jiang Li
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain wit
Externí odkaz:
https://doaj.org/article/1ad3b4db4c394103a85e3bf0e6a99565
Autor:
Huiming Yang, Su Yang, Liang Jing, Luoxiu Huang, Luxiao Chen, Xianxian Zhao, Weili Yang, Yongcheng Pan, Peng Yin, Zhaohui S Qin, Beisha Tang, Shihua Li, Xiao-Jiang Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19873-9
Externí odkaz:
https://doaj.org/article/68230752996a4458ba74ebb2e18ede7c
Publikováno v:
Micromachines, Vol 11, Iss 7, p 652 (2020)
Fresnel micro-structured lenses are widely used in the field of modern optoelectronic technology. High-precision Fresnel micro-structured mold is the key technology to achieve its large-scale replication production. Focusing on the surface waviness e
Externí odkaz:
https://doaj.org/article/72169696abbd4968a0d3fdf8993947d1
Publikováno v:
Chinese Journal of Lung Cancer, Vol 12, Iss 3, Pp 187-191 (2009)
Background and objective It has been proven that chemotherapy failure caused by multidrug resistance in lung tumor cells is the main cause for the patient's survival rate. The aim of this study is to establish a multidrug resistance cell line of huma
Externí odkaz:
https://doaj.org/article/a192a85bfe7544d7a6492ef68380ec9a