Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yongchao C. Ma"'
Autor:
Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood gluc
Externí odkaz:
https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae37
Autor:
Han-Xiang Deng, Hong Zhai, Yong Shi, Guoxiang Liu, Jessica Lowry, Bin Liu, Éanna B. Ryan, Jianhua Yan, Yi Yang, Nigel Zhang, Zhihua Yang, Erdong Liu, Yongchao C. Ma, Teepu Siddique
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Deng et al. assess the effects of CRISPR/Cas9-mediated genome editing in two transgenic mouse models of amyotrophic lateral sclerosis (ALS) for up to 2 years. They find that the genomic editing prevented the development of ALS-like pathology without
Externí odkaz:
https://doaj.org/article/e548fc08a9654fe99fd22baa46408209
Autor:
Éanna B. Ryan, Jianhua Yan, Nimrod Miller, Sudarshan Dayanidhi, Yongchao C. Ma, Han-Xiang Deng, Teepu Siddique
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102061- (2021)
Summary: Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) have been identified in patients suffering from various degenerative diseases including mitochondrial myopathy, spinal muscular atrophy Jokela type, frontotempor
Externí odkaz:
https://doaj.org/article/33aca3422669407a9e11c79ae56d769e
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/8ba1612a65364753a510c055e02c643f
Autor:
Xiaoyang Gao, Jing Xu, Hao Chen, Dingwu Xue, Wenju Pan, Chuanman Zhou, Yongchao C. Ma, Long Ma
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Spinal muscular atrophy (SMA) is a severe motor neuron degenerative disease caused by loss-of-function mutations in the survival motor neuron gene SMN1. It is widely posited that defective gene expression underlies SMA. However, the identities of the
Externí odkaz:
https://doaj.org/article/671c0ee67e3d4e7cb5fde4113f042186
Publikováno v:
eLife, Vol 6 (2017)
The etiological underpinnings of amyotrophic lateral sclerosis (ALS) are complex and incompletely understood, although contributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent. Here, we present a novel var
Externí odkaz:
https://doaj.org/article/d56a80c9cd784894b56a22723e6abfe1
Autor:
Gangjian Qin, Baolong Yan, Junlan Zhou, Jianyi Zhang, Liu Yang, Yongchao C. Ma, Chan Boriboun, Aijun Qiao, Chunxiang Zhang, Teayoun Kim, Eric Zhang, Hongyu Qiu, Stéphane Richard, Jianxin Deng, Shiyue Xu, Yuhua Song, Kirk M. Habegger, Wenxia Ma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Hepatic gluconeogenesis is essential for glucose homeostasis and also a therapeutic target for type 2 diabetes, but its mechanism is incompletely understood. Here, we report that Sam68, an RNA-binding adaptor protein and Src kinase substrate, is a no
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The RNA modification N
Autor:
Phillip J, Hsu, Hailing, Shi, Allen C, Zhu, Zhike, Lu, Nimrod, Miller, Brittany M, Edens, Yongchao C, Ma, Chuan, He
Publikováno v:
J Biol Chem
N(6)-Methyladenosine (m(6)A) is the most abundant post-transcriptional mRNA modification in eukaryotes and exerts many of its effects on gene expression through reader proteins that bind specifically to m(6)A-containing transcripts. Fragile X mental
Autor:
Brittany M, Edens, Caroline, Vissers, Jing, Su, Saravanan, Arumugam, Zhaofa, Xu, Han, Shi, Nimrod, Miller, Francisca, Rojas Ringeling, Guo-Li, Ming, Chuan, He, Hongjun, Song, Yongchao C, Ma
Publikováno v:
Cell reports
SUMMARY N6-methyladenosine (m6A) modification of mRNA is emerging as a vital mechanism regulating RNA function. Here, we show that fragile X mental retardation protein (FMRP) reads m6A to promote nuclear export of methylated mRNA targets during neura