Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Yongchang Qiu"'
Publikováno v:
Bioanalysis. 11:393-406
Aim: Develop LC–MS/MS-based assays to measure total and free complement C5 in cynomolgus monkey serum as a target engagement biomarker for pharmacokinetic/pharmacodynamic correlation study. Materials & methods/results: The C5-specific signature pep
Autor:
Carolina Guerini de Souza, Jiang Wu, Lakshmi Amaravadi, Amauri Dalla Corte, Mu Chen, Yongchang Qiu, Zhiling Zhang, Luying Pan, Roberto Giugliani, Peng Pan
Publikováno v:
Bioanalysis. 10:825-838
Aim: The study aimed to develop an LC–MS/MS assay to measure dermatan sulfate (DS) in human cerebrospinal fluid (CSF). Methods & results: DS was quantified by ion pairing LC–MS/MS analysis of the major disaccharides derived from chondroitinase B
Publikováno v:
Bioanalysis. 9:1477-1491
Aim: C1-INH-HAE is caused by activation of plasma kallikrein which subsequently cleaves high-molecular-weight kininogen (HMWK) to generate bradykinin and cHMWK. Materials & methods: A novel ion-pair 2D LC–MS/MS assay was developed to measure the 46
Publikováno v:
Bioanalysis. 9:1603-1615
Aim: Development of drug-related surrogate positive controls for isotype anti-drug antibodies assay remains challenging. Efforts on antibody engineering or chemical crosslinking have been made. However, multiple epitope recognition, purity and stabil
Autor:
Akiko Ishii-Watabe, Albert Torri, Rong Zeng, Daniel Kramer, Steven P. Piccoli, David J. Uhlinger, Stephanie Fraser, Patricia Siguenza, Afshin Safavi, John Smeraglia, Apollon Papadimitriou, Yan G. Ni, Susan M. Richards, Kyra J. Cowan, Alessandra Vitaliti, Lakshmi Amaravadi, Boris Gorovits, Gustavo Mendes Lima Santos, John Kadavil, Sam Haidar, Jan Welink, Yongchang Qiu, João Pedras-Vasconcelos, Chan C. Whiting, Li Xue, Christina Satterwhite, John Kamerud, Swati Gupta, Natasha Savoie, Herbert Birnboeck, Yoshiro Saito, Paul Rhyne, Fabrizio Galliccia, Laurent Cocea, Stephanie Croft, Bonnie Wu, Theingi M. Thway, Virginia Litwin, Corinna Krinos-Fiorotti, Darshana Jani, Charles S Hottenstein, Vinita Gupta, Roland F Staack, Fabio Garofolo, Eginhard Schick, Kara Scheibner, Meena Subramanyam, John Allinson, Renuka Pillutla, Robert Nelson, Flora Berisha, Martin Ullmann, Giane Sumner
Publikováno v:
Bioanalysis. 8:2475-2496
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizatio
Publikováno v:
Bioanalysis. 11(10)
Aim: Myostatin (MSTN) is an attractive therapeutic target for the treatment of muscle degeneration-related diseases and is being evaluated as a target engagement biomarker. Methods: A sensitive 2D-LC–MS/MS assay was developed to quantify MSTN in di
Publikováno v:
Molecular genetics and metabolism. 127(1)
Fabry disease is a lysosomal storage disorder caused by mutations in the GLA gene that encodes for the lysosomal enzyme α-galactosidase A (α-Gal A). Reduced or absent α-Gal A activity leads to substrate accumulation and deleterious effects in mult
Publikováno v:
Bioanalysis. 9(16)
Aim: Legacy methods with complex testing scheme for characterization of anti-idursulfase antibodies (ADA) were simplified and optimized in order to meet current regulatory guidance and provide more timely and cost-effective support for routine patien
Autor:
Yongchang Qiu, Quinn Dinh, Tobias Böttcher, Claudia Cozma, Lan Lan, Björn Mellgard, Sabrina Eichler, Ari Zimran, Deborah Elstein
Publikováno v:
Molecular genetics and metabolism. 122(1-2)
Gaucher disease (GD), an autosomal recessive lipid storage disorder, arises from mutations in the GBA1 (β-glucocerebrosidase) gene, resulting in glucosylceramide accumulation in tissue macrophages. Lyso-Gb1 (glucosylsphingosine, lyso-GL1), a downstr
Publikováno v:
Bioanalysis. 9(10)
Aim: To provide more efficient and timely immunogenicity testing service to support routine patient care, the original complex testing algorithm for evaluation of anti-velaglucerase alfa antibodies has been simplified and individual methods (screen,