Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Yongbo, Hu"'
Autor:
Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Lysosomal homeostasis and functions are essential for the survival of neural cells. Impaired lysosomal biogenesis and acidification in Alzheimer’s disease (AD) pathogenesis leads to proteolytic dysfunction and neurodegeneration.
Externí odkaz:
https://doaj.org/article/3ea5a9c842a046a092488d50aaae8355
Autor:
Lufeng Wang, Yiwen Bao, Xiaofan Duan, Hongxia Li, Hao Ding, Fei Yu, Jie yang, Yongbo Hu, Dongya Huang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Circadian rhythm (CR) disturbance is intricately associated with Parkinson’s disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive. Methods A total of 141 PD pa
Externí odkaz:
https://doaj.org/article/fa02568a299f48778e533e58a36e566a
Autor:
Qian Li, Youjin Zhao, Yongbo Hu, Yang Liu, Yaxuan Wang, Qian Zhang, Fenghua Long, Yufei Chen, Yitian Wang, Haoran Li, Eline M.P. Poels, Astrid M. Kamperman, John A. Sweeney, Weihong Kuang, Fei Li, Qiyong Gong
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105255- (2024)
Summary: Background: Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found to be altered in major depressive disorder (MDD). Both depressive symptoms
Externí odkaz:
https://doaj.org/article/fec359f8a1e34edca3f4f132051b4024
Autor:
Jin Li, Xin Yang, Huifang Xu, Yongbo Hu, Weihong Kuang, Yuwei Zhang, Wenqi Lu, Fangzhou Liu, Xiance He
Publikováno v:
BMJ Mental Health, Vol 27, Iss 1 (2024)
Background Behavioural and psychological symptoms of dementia (BPSD) are highly prevalent in people living with dementia. Second-generation antipsychotics (SGAs) are commonly used to treat BPSD, but their comparative efficacy and acceptability are un
Externí odkaz:
https://doaj.org/article/a57954183ba343c688d0c358ff8df776
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionMajor depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain.MethodsThis cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enri
Externí odkaz:
https://doaj.org/article/2c45910544234e4cb7e319b86138a15e
Autor:
Huifang Xu, Tongtong Li, Qiyong Gong, Haizhen Xu, Yongbo Hu, Wenqi Lü, Xin Yang, Jin Li, Wenming Xu, Weihong Kuang
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundThe retrograde endocannabinoid (eCB) pathway is closely associated with the etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels. This study aimed to investigate the potential role of genetic mutations i
Externí odkaz:
https://doaj.org/article/3adff1fe05224c77a125a4f26597d66c
Autor:
Qingbin Li, Zhaohua Zhang, Guocai Chen, Yongbo Hu, Rongjun Mao, Le Xie, Shaoluan Chen, Yongqiang Lao, Junqing Gao
Publikováno v:
Frontiers in Surgery, Vol 9 (2023)
Giant cell angioblastoma is a relatively rare vasogenic tumour. To date, studies on its clinical manifestations, imaging characteristics, pathological features, and prognosis are extremely limited and unknown, with only a few cases recorded. In this
Externí odkaz:
https://doaj.org/article/d73a2148e8b54901ace65a40c7489d9c
Autor:
Peng Yin, Jinlei Qi, Maigeng Zhou, Ying Wang, Chunbo Li, Qiang Huang, Yikang Zhu, Yongbo Hu, Zhihui Wang, Yuan Zhu, Jianping Li, Gang Wang, Yiran Wang, Pengfei Wang, Rujing Ren, Shaohui Lin, Xinya Liu, Ran Tang, Jintao Wang, Xinyi Xie, Shishuang Cui, Xiaoping Yu, Yanyan Huang, Yisong Hu
Publikováno v:
General Psychiatry, Vol 35, Iss 1 (2022)
China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated, especially Alzheimer’s disease (AD) and related dementias (ADRD). AD’s incidence rate, morbidity, a
Externí odkaz:
https://doaj.org/article/20056dbe604345129fdbc7bd8fddbed0
Publikováno v:
Earth and Space Science, Vol 8, Iss 3, Pp n/a-n/a (2021)
Abstract The isotopic composition of surface water vapor flux (δE) is a quantity frequently used to investigate the local and regional water cycle. This study reports the results of a comparative evaluation of δE determined with the Keeling plot an
Externí odkaz:
https://doaj.org/article/7fe57cf50c9840f992a2bf9ad2825370
Autor:
Qian Zhang, Qingxiang Song, Xiao Gu, Mengna Zheng, Antian Wang, Gan Jiang, Meng Huang, Huan Chen, Yu Qiu, Bin Bo, Shanbao Tong, Rong Shao, Binyin Li, Gang Wang, Hao Wang, Yongbo Hu, Hongzhuan Chen, Xiaoling Gao
Publikováno v:
Advanced Science, Vol 8, Iss 2, Pp n/a-n/a (2021)
Abstract Cerebrovascular dysfunction characterized by the neurovascular unit (NVU) impairment contributes to the pathogenesis of Alzheimer's disease (AD). In this study, a cerebrovascular‐targeting multifunctional lipoprotein‐biomimetic nanostruc
Externí odkaz:
https://doaj.org/article/22385230ba9a4170aef1308fc00807ca