One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization

Autor: Gang Cheng, Yingbei Qi, Xiaoqian Zhou, Rong Sheng, Yong-Zhou Hu, Youhong Hu

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract We developed an efficient synthesis of aza-chromones from 3-iodo-4-(1H)-pyridones and terminal acetylenes via a cascade carbonylation-Sonogashira-cyclization reaction. By controlling the use of bases, both 6-aza-chromones 5 and 3-(4-oxo-1,4-

Externí odkaz: https://doaj.org/article/e2290e184752452ab45873be86b563b7

Data from Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1

Autor: Bo Yang, Qiao-jun He, Neng-ming Lin, Yong-zhou Hu, Xiao-wu Dong, Hai Jiang, Liu-qing Yang, Hong Zhu, Tian-yu Cai, Chong Zhang

The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL, but not Mcl-1, which may confer resistance to this agent in various cancers with high levels of Mcl-1. Here, we showed that the combination of gemcitabine and ABT-737 exhibited synergistic cytotoxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc21bba522acfd16e1d4d2120bb3ad8b
https://doi.org/10.1158/1535-7163.c.6535453

A H2O2-Responsive Theranostic Probe for Endothelial Injury Imaging and Protection

Autor: Yong Zhou Hu, Quan Jiang, Cheng Kun Wang, Chao Tan, Ying Mei Lu, Xin Li, Xing Guang Liang, Kohji Fukunaga, Juan Cheng, Feng Han

Publikováno v: Theranostics

Overproduction of H2O2 causes oxidative stress and is the hallmark of vascular diseases. Tracking native H2O2 in the endothelium is therefore indispensable to gain fundamental insights into this pathogenesis. Previous fluorescent probes for H2O2 imag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f546858a277b39276955e54c33357ddb
https://doi.org/10.7150/thno.21068

Voltammetric Study of Some 3-Aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide Derivatives with Anti-Tumor Activities

Autor: Qing Xia, Christina M. Ragain, Austin W. Nenninger, Krystina A. Brillos-Monia, Mariah E. Cella, Rong Sheng, Monica N. Mruzik, Philip W. Crawford, Yong Zhou Hu, Eric M. Miller

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 9, p 1442 (2017)
Molecules; Volume 22; Issue 9; Pages: 1442

The electrochemical properties of twenty 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives with varying degrees of cytotoxic activity were investigated in dimethylformamide (DMF) using cyclic voltammetry and first derivative cyclic voltamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851375dc862949938804b00195fbd749
https://pubmed.ncbi.nlm.nih.gov/28858261

Simple and Efficient One‐Pot Synthesis of 2,4‐Diaryl‐1,2,3‐triazoles

Autor: Yong‐Zhou Hu, Wen‐Jie Tang

Publikováno v: Synthetic Communications. 36:2461-2468

A general and efficient method for the preparation of 2,4‐diaryl‐1,2,3‐triazoles from α‐hydroxyacetophenones and phenylhydrazines is reported. The essential characteristics of this method include mild reaction conditions, a straightforward w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb4d31501834969910676e3e7e6f626a
https://doi.org/10.1080/00397910600781216