Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Yong-Xing He"'
Autor:
Si-Ping Zhang, Han-Zhong Feng, Qian Wang, Megan L. Kempher, Shuo-Wei Quan, Xuanyu Tao, Shaomin Niu, Yong Wang, Hu-Yuan Feng, Yong-Xing He
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 86-93 (2021)
The post-translational modification (PTM) serves as an important molecular switch mechanism to modulate diverse biological functions in response to specific cues. Though more commonly found in eukaryotic cells, many PTMs have been identified and char
Externí odkaz:
https://doaj.org/article/9234664b9bbf442c9255aa7ab614fca1
Autor:
Jian-Ting Han, Yongchang Zhu, Da-Bo Pan, Hong-Xiang Xue, Shuang Wang, Yali Peng, Huanxiang Liu, Yong-Xing He, Xiaojun Yao
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4079-4091 (2021)
FKBP51 is well-known as a cochaperone of Hsp90 machinery and implicated in many human diseases including stress-related diseases, tau-mediated neurodegeneration and cancers, which makes FKBP51 an attractive drug target for the therapy of FKBP51-assoc
Externí odkaz:
https://doaj.org/article/a392da26029f42f29b25a5ef26456ff0
Autor:
Di-Yin Li, Jian-Ting Han, Meng-Yuan Zhang, Xu Yan, Nannan Zhang, Honghua Ge, Zhiping Wang, Yong-Xing He
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or transiently induced by various environmental signals, which are t
Externí odkaz:
https://doaj.org/article/0682c3ebd762474f8f9ddcea27e026ce
Autor:
Ding-Ding Guo, Li-Ming Luo, Hai-Long Ma, Si-Ping Zhang, Hang Xu, Honghua Zhang, Yong Wang, Yongna Yuan, Zhen Wang, Yong-Xing He
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Pseudomonas aeruginosa is an opportunistic pathogen commonly infecting immunocompromised patients with diseases like cystic fibrosis (CF) and cancers and has high rates of recurrence and mortality. The treatment efficacy can be significantly worsened
Externí odkaz:
https://doaj.org/article/83b177f2a8e346ee8a4087db9841afe7
Autor:
Zi-Yang Zhang, Hu-Hu Bai, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Yong-Xing He, Xiao-Dong Hu
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000371 (2019)
Inhibitory glycinergic transmission in adult spinal cord is primarily mediated by glycine receptors (GlyRs) containing the α1 subunit. Here, we found that α1ins, a longer α1 variant with 8 amino acids inserted into the intracellular large loop (IL
Externí odkaz:
https://doaj.org/article/36d2b8262ad14b069f33cac37a41ee09
Autor:
Yinnan Mu, Fu-Ming Lian, Yan-Bin Teng, Jingqun Ao, Yong-Liang Jiang, Yong-Xing He, Yuxing Chen, Cong-Zhao Zhou, Xinhua Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57061 (2013)
Peroxiredoxins (Prxs) are thiol-specific antioxidant proteins that exhibit peroxidase and peroxynitrite reductase activities involved in the reduction of reactive oxygen species. The peroxiredoxin Prx4 from the large yellow croaker Pseudosciaena croc
Externí odkaz:
https://doaj.org/article/d01f9dc3ed3b4945819c7ee2ef950ca1
Autor:
Tao Xu, Xuanyu Tao, Hongxi He, Megan L. Kempher, Siping Zhang, Xiaochun Liu, Jun Wang, Dongyu Wang, Daliang Ning, Chongle Pan, Honghua Ge, Nannan Zhang, Yong-Xing He, Jizhong Zhou
Publikováno v:
The ISME Journal. 17:823-835
Autor:
Yi-Bo Zhu, Rui Bao, Siying Wu, Ying-Jie Song, Chang-Cheng Li, Xingyu Mou, Guihua Luo, Yong-Xing He, Qin Huang, Yalin Shen, Aiping Tong, Tong-Gen Liu, Siping Zhang, Xinyue Tang
Publikováno v:
ACS Infectious Diseases. 7:2930-2940
Bacterial type II toxin-antitoxin (TA) systems are abundant genetic elements and are involved in a diverse array of physiological processes. These systems encode an antitoxin protein that directly binds and effectively neutralizes the protein toxin.
Autor:
Yongchang Zhu, Hong-Xiang Xue, Shuang Wang, Huanxiang Liu, Yali Peng, Dabo Pan, Han Jianting, Yong-Xing He, Xiaojun Yao
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4079-4091 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4079-4091 (2021)
Graphical abstract Peptide-inhibitor hits were designed with small molecules published before used as the starting point through structure-based drug design and biochemically and structurally characterized the interaction modes between the FK1 domain
Autor:
Xuanyu Tao, Si-Ping Zhang, Hu-Yuan Feng, Han-Zhong Feng, Yong Wang, Qian Wang, Megan L. Kempher, Yong-Xing He, Shuo-Wei Quan, Shaomin Niu
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 86-93 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 86-93 (2021)
The post-translational modification (PTM) serves as an important molecular switch mechanism to modulate diverse biological functions in response to specific cues. Though more commonly found in eukaryotic cells, many PTMs have been identified and char