Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Yong-Sung Juhnn"'
Autor:
Sung Eun Noh, Yong Sung Juhnn
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
DNA double-strand breaks (DSB) are formed by various exogenous and endogenous factors and are repaired by homologous recombination and non-homologous end joining (NHEJ). DNA-dependent protein kinase (DNA-PK) is the principal enzyme for NHEJ. We explo
Autor:
Sung Eun Noh, Yong Sung Juhnn
Publikováno v:
Journal of Korean Medical Science
Background Cyclic AMP (cAMP) signaling is activated by various hormones and neurotransmitters and regulates numerous physiological phenomena, including energy metabolism, gene expression, and proliferation. cAMP signaling plays a role in the repair o
Autor:
Ji Yeon Park, Yong Sung Juhnn
Publikováno v:
Biochemical and Biophysical Research Communications. 470:336-342
This study aimed to investigate the roles of autophagy and the ubiquitin-proteasome system in the degradation of histone deacetylase 8 (HDAC8) and to clarify the mechanism by which cAMP signaling regulates this degradation. cAMP signaling was activat
Autor:
Yong Sung Juhnn, Eui Jun Kim
Publikováno v:
Journal of Biological Chemistry. 290:9604-9613
The cAMP signaling system regulates various cellular functions, including metabolism, gene expression, and death. Sirtuin 6 (SIRT6) removes acetyl groups from histones and regulates genomic stability and cell viability. We hypothesized that cAMP modu
Autor:
Eun Ah Cho, Yong Sung Juhnn
Publikováno v:
Biochemical and Biophysical Research Communications. 422:256-262
Cyclic AMP is involved in the regulation of metabolism, gene expression, cellular growth and proliferation. Recently, the cAMP signaling system was found to modulate DNA-damaging agent-induced apoptosis by regulating the expression of Bcl-2 family pr
Autor:
Jae Moon Koh, Ye-Young Rhee, Jeong Mo Bae, Donguk Kim, Yong-Sung Juhnn, Nam-Yun Cho, Mi Jung Kim, Gyeong Hoon Kang
Publikováno v:
Annals of Surgical Oncology. 19:3441-3448
The prognostic significance of microsatellite instability (MSI) in colorectal cancers (CRCs) has been addressed in many studies since the initial description of better survival rates in MSI-positive (MSI+) tumors than in MSI-negative (MSI-) tumors. R
Autor:
Yong Sung Juhnn, Yong Sang Song, Mi Kyung Kim, Jung Min Oh, Su Hyeong Kim, Jeong Mook Lim, Jae Yong Han, Hee Seung Kim
Publikováno v:
Biochemical Pharmacology. 80:1930-1935
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and
Autor:
Yong Sung Juhnn, Mi Ran Seo
Publikováno v:
Biochemical and Biophysical Research Communications. 393:190-195
Ultraviolet (UV) radiation induces cyclooxygenase-2 expression to produce cellular responses including aging and carcinogenesis in skin. We hypothesised that heterotrimeric G proteins mediate UV-induced COX-2 expression by stimulating secretion of so
Publikováno v:
Cancer Science. 100:1069-1074
The present study aimed to investigate the effect of the stimulatory heterotrimeric GTP-binding (Gs) protein signaling system on cisplatin-induced apoptosis of lung cancer cells and its underlying mechanism as an attempt to develop a novel strategy t
Autor:
Yong Sung Juhnn, Ung Gu Kang, Won Je Jeon, Yong Sik Kim, Yeni Kim, Myoung Suk Seo, Se Hyun Kim, Yong Min Ahn
Publikováno v:
Psychiatry Research. 167:80-87
Repeated administration of NMDA antagonists can induce behavioral alterations that mimic symptoms of psychosis, as seen in schizophrenia. JNK, one of the MAPKs, and c-Jun, its downstream target molecule, play important roles in regulating apoptosis i