Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Yong-Quan LI"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 766-774 (2024)
The anti-Clostridium difficile infection (CDI) drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae, such as Actinoplanes deccanensis, Dactylosporangium aurantiacum, and Micromonospora echinospora. In the present
Externí odkaz:
https://doaj.org/article/77bd29f45cf24682930b4e3df50f7cb0
Autor:
Huang Xie, Jing-Yi Ruan, Qing-Ting Bu, Yue-Ping Li, Yi-Ting Su, Qing-Wei Zhao, Yi-Ling Du, Yong-Quan Li
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Fidaxomicin is an 18-membered glycosidic macrolide polyketide that was clinically used in the treatment of Clostridium difficile infection in 2011. Although the biosynthetic mechanism and pathway-specific regulator of fidaxomicin were well e
Externí odkaz:
https://doaj.org/article/aeb9e410ed2f4fc6931b851f294df1b3
Autor:
Jiao-Le Fang, Wen-Li Gao, Wei-Feng Xu, Zhong-Yuan Lyu, Lie Ma, Shuai Luo, Xin-Ai Chen, Xu-Ming Mao, Yong-Quan Li
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 4, Pp 1013-1023 (2022)
Despite numerous studies on transcriptional level regulation by single genes in drug producing Actinomyces, the global regulation based on epigenetic modification is not well explored. N4-methylcytosine (m4C), an abundant epigenetic marker in Actinom
Externí odkaz:
https://doaj.org/article/fc233d9e346e4fc092beb08ab7219152
Publikováno v:
SAGE Open, Vol 13 (2023)
Online learning platforms have become important learning tools, and online learning replaced face-to-face teaching as the primary learning method of students during COVID-19. However, there have been few systematic studies on learning effectiveness a
Externí odkaz:
https://doaj.org/article/18e33404ae58446c999c17b0d3eff25b
Autor:
Wen-Li Gao, Jiao-Le Fang, Chen-Yang Zhu, Wei-Feng Xu, Zhong-Yuan Lyu, Xin-Ai Chan, Qing-Wei Zhao, Yong-Quan Li
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes. However, research on strain optimization utilizing DN
Externí odkaz:
https://doaj.org/article/c3b8cff9475640f4a6317dfbde912df3
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 6, Pp 1852-1866 (2022)
Summary The metabolic flux of fatty acyl‐CoAs determines lipopeptide biosynthesis efficiency, because acyl donor competition often occurs from polyketide biosynthesis and homologous pathways. We used A40926B0 as a model to investigate this mechanis
Externí odkaz:
https://doaj.org/article/1637a97c99cf41909f8c7700d73dcacf
Publikováno v:
Microorganisms, Vol 11, Iss 10, p 2578 (2023)
Asperpyridone A represents an unusual class of pyridone alkaloids with demonstrated potential for hypoglycemic activity, primarily by promoting glucose consumption in HepG2 cells. Trichodin A, initially isolated from the marine fungus Trichoderma sp.
Externí odkaz:
https://doaj.org/article/f2a5ec76e5294ec6b354806ab2004c6c
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-11 (2021)
Abstract Background FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermen
Externí odkaz:
https://doaj.org/article/4f73078de95a4f01a5ec0b8fcee0c870
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The emergence of drug resistance highlights the importance of new drug discovery. Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of these BGCs are cryptic. Thus, taking strate
Externí odkaz:
https://doaj.org/article/12ecd479347741f29a91009bac025c0b
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Secondary metabolites as natural products from endophytic fungi are important sources of pharmaceuticals. However, there is currently little understanding of endophytic fungi at the omics levels about their potential in secondary
Externí odkaz:
https://doaj.org/article/f5801cc6e5e146789c91994f7d5b553a