SNS-032 attenuates liver fibrosis by anti-active hepatic stellate cells via inhibition of cyclin dependent kinase 9

Autor: Xiao-Li He, Yong-Hong Hu, Jia-Mei Chen, Ding-Qi Zhang, Hai-Lin Yang, Lin-Zhang Zhang, Yong-Ping Mu, Hua Zhang, Gao-Feng Chen, Wei Liu, Ping Liu

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Liver fibrosis is a common pathological process of all chronic liver diseases. Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis. Cyclin-dependent kinase 9 (CDK9) is a cell cycle kinase that regulates mRNA transcr

Externí odkaz: https://doaj.org/article/94b13ebd5b824377833fbc26c86a9136

Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling

Autor: Zhun, Xiao, Qiang, Ji, Ya-Dong, Fu, Si-Qi, Gao, Yong-Hong, Hu, Wei, Liu, Gao-Feng, Chen, Yong-Ping, Mu, Jia-Mei, Chen, Ping, Liu

Publikováno v: Chinese journal of integrative medicine.

To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model, and the underlying mechanisms were partly dissected in vivo and in vitro.Thirty-two male mice were randomly divided into 4 groups, including control, model, low- an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6647c1461d8271ad2a332c0d07f5ebb
https://pubmed.ncbi.nlm.nih.gov/34816365

Research progress on signaling pathways in cirrhotic portal hypertension

Autor: Yong-Ping Mu, Ping Liu, Wen Xu

Publikováno v: World Journal of Clinical Cases

Portal hypertension (PHT) is an important consequence of liver cirrhosis, which can lead to complications that adversely affect a patient's quality of life and survival, such as upper gastrointestinal bleeding, ascites, and portosystemic encephalopat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3527fdd8e9604e6a59db84625b7c97be
https://doi.org/10.12998/wjcc.v6.i10.335

Evaluation of Fast Food Behavior in Pre-School Children and Parents Following a One-Year Intervention with Nutrition Education

Autor: Wenjie Sun, Yongjun Zhang, Dong Dong Ling, Fengqiong Liu, Mao Wang, Tingting Liu, Yongqing Gao, Yuee Huang, Cindy Feng, Siobhan L. Tarver, Changwei Li, Yong-Ping Mu

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 11, Iss 7, Pp 6780-6790 (2014)
International Journal of Environmental Research and Public Health; Volume 11; Issue 7; Pages: 6780-6790

A community-based intervention study was conducted to assess a nutrition education intervention on western style fast food consumption among Chinese children and parents. Eight kindergartens from three district areas of Hefei City (a total of 1252 ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce9e44c1ac68ebfa850384b25f757ab
https://doi.org/10.3390/ijerph110706780

Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine–choline-deficient diet

Autor: Norifumi Kawada, Yong-ping Mu, Tomohiro Ogawa

Publikováno v: Laboratory Investigation. 90:245-256

Fatty liver disease has become a health problem related to metabolic syndrome worldwide, although its molecular pathogenesis requires further study. It is also unclear whether advanced fibrosis of steatohepatitis will regress when diet is controlled.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551112eb3632983a6f5cbf8483e6b4e2
https://doi.org/10.1038/labinvest.2009.123